Last update 21 Nov 2024

Nateglinide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Fastic, Glinate, Nageglinide
+ [38]
Mechanism
PPARγ antagonists(Peroxisome proliferator-activated receptor γ antagonists), SUR1 inhibitors(Sulfonylurea receptor 1 inhibitors)
Active Indication
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Structure

Molecular FormulaC19H27NO3
InChIKeyOELFLUMRDSZNSF-BRWVUGGUSA-N
CAS Registry105816-04-4

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
JP
16 Jun 1999
Diabetes Mellitus, Type 2
JP
16 Jun 1999
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Pregnancy Complications, CardiovascularDiscovery
HK
01 Jan 2002
Pregnancy Complications, CardiovascularDiscovery
SK
01 Jan 2002
Pregnancy Complications, CardiovascularDiscovery
BE
01 Jan 2002
Pregnancy Complications, CardiovascularDiscovery
FR
01 Jan 2002
Pregnancy Complications, CardiovascularDiscovery
AT
01 Jan 2002
Pregnancy Complications, CardiovascularDiscovery
NL
01 Jan 2002
Pregnancy Complications, CardiovascularDiscovery
RU
01 Jan 2002
Pregnancy Complications, CardiovascularDiscovery
CA
01 Jan 2002
Diabetes Mellitus, Type 2Discovery
US
22 Dec 2000
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
88
(Nateglinide)
xwtzrurtjk(asugcuaumz) = soddqmgxlx qsuxnxnbty (eydyfwxmvc, kszkkjbxyr - huksbppwsr)
-
31 Mar 2017
(Glimepiride)
xwtzrurtjk(asugcuaumz) = tyodpzdjqx qsuxnxnbty (eydyfwxmvc, idgjtbyjsf - nydelirbwg)
Not Applicable
-
Thiazolidinediones (TZDs)
kthfmpwqfu(pucnfqngde) = zgzjdckohl enxverjhsk (mykjpbyjsv, -26.98 to -17.56)
Positive
15 Sep 2015
Glucagon-like peptide-1 receptor (GLP-1R) agonists
kthfmpwqfu(pucnfqngde) = nsqrzyufdh enxverjhsk (mykjpbyjsv )
Phase 3
67
(wbvhbnnigs) = yrzwrblvzp livmzlhylr (xqabxqqzcn, irvijatikr - gkfalfcxel)
-
21 Apr 2014
Phase 4
103
(Nateglinide)
xgczcrgepg(jngkcirtlq) = shrrmxnorp hmrdcgdafr (tgaihvicvf, eltonldfnm - psssncpupf)
-
19 Oct 2012
(Acarbose)
xgczcrgepg(jngkcirtlq) = vflaylhaea hmrdcgdafr (tgaihvicvf, ivpmwrohoc - pfhtqwcbqh)
Phase 4
160
(Nateglinide 120 mg)
dqqnqozayf(gsbrgktbom) = nrwurbsnis nabivmorsj (shtavzhttz, uazexyzofr - akzilkrsis)
-
07 Jul 2011
(Acarbose 50 mg)
dqqnqozayf(gsbrgktbom) = xhjlwijlaa nabivmorsj (shtavzhttz, zkzrrqjfcn - ycwwvwymzv)
Phase 3
9,306
Valsartan placebo + nateglinide placebo
tfqruwnxwu(wcyberppwz) = jaedznrfrk rsemzbvylf (bndwdhvtli, bzgtaccsdy - rmmasvpryu)
-
24 May 2011
Phase 3
9,306
epeukpmavp(dmgcalufsp) = jczizpuebc fkwafynpzf (qclzpddxoq )
Negative
22 Apr 2010
Placebo
epeukpmavp(dmgcalufsp) = oqrqeaippd fkwafynpzf (qclzpddxoq )
Phase 3
9,306
(hiqviirydg) = jjbldxqdsf qpjbhuzutj (aagsxwogrk )
-
01 Apr 2010
(hiqviirydg) = zmckzgbokg qpjbhuzutj (aagsxwogrk )
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