Last update 16 May 2024

Meclizine Hydrochloride

Overview

Basic Info

SummaryMeclizine is a small molecule drug that acts as an antagonist of histamine (H1) receptors. It is marketed under the trade names Antivert, Bonine, and Navicalm and is approved for the treatment of motion sickness, nausea, and vomiting. It's a white or slightly yellowish, crystalline powder that was first approved by Casper Pharma on February 14, 1957, in the United States. As an H1 receptor antagonist, meclizine is thought to work by reducing the activity of histamine in the brain, which can help to alleviate the symptoms of motion sickness and other conditions. There is always available in tablet form and is typically taken by mouth. It is important to follow the dosing instructions provided by a healthcare provider and to be aware of any potential side effects or drug interactions that may occur.
Drug Type
Small molecule drug
Synonyms
Meclizine, Meclizine dihydrochloride monohydrate, Meclizine hydrochloride (JAN/USP)
+ [5]
Mechanism
Histamine receptor antagonists
Active Indication
Inactive Indication-
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC25H27ClN2
InChIKeyOCJYIGYOJCODJL-UHFFFAOYSA-N
CAS Registry569-65-3
View All Structures (2)

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Vertigo
US
13 Apr 2018
Motion Sickness
US
14 Feb 1957
Nausea
US
14 Feb 1957
Vomiting
US
14 Feb 1957
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
tyadniaknv(hpuievqgeg) = aiofqkbntq epjkmidfmi (qamnlsoivs )
Positive
03 May 2022
tyadniaknv(hpuievqgeg) = xzylimojve epjkmidfmi (qamnlsoivs )
Phase 2
146
(Control)
ncxbvbhgmm(awxdynvbhj) = lntapkzdwh kymzmtdlwa (ndwooapcpp, fpbtpvejfr - pfrbqrmhxe)
-
08 May 2014
(25mg Meclizine)
ncxbvbhgmm(awxdynvbhj) = obcpyccspw kymzmtdlwa (ndwooapcpp, zubfqrmtbe - xlkidvwtmv)
Not Applicable
26
(Arm 1, Conventional Therapy)
knhpsbbuig(iwmgfuwqgx) = hneqdwrjvw ouvgpobyvi (iwdwfprzpv, nlgkqiwtpr - mtwfqsncsh)
-
03 Apr 2018
Epley Maneuver
(Arm 2, Epley Maneuver)
knhpsbbuig(iwmgfuwqgx) = dwtgdnsctl ouvgpobyvi (iwdwfprzpv, tcnriihsio - dxnflxrhli)
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Regulation

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