Last update 15 Sep 2024

Paroxetine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Paroxetine, Paroxetine betaciclodextrin, Paroxetine Hydrochloride Hydrate
+ [20]
Target
Mechanism
SERT inhibitors(Serotonin transporter inhibitors)
Therapeutic Areas
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
Regulation-
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Structure

Molecular FormulaC19H21ClFNO3
InChIKeyGELRVIPPMNMYGS-RVXRQPKJSA-N
CAS Registry78246-49-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Premenstrual Dysphoric Disorder
US
28 Aug 2003
Panic
JP
22 Sep 2000
Generalized anxiety disorder
US
25 Jun 1997
Stress Disorders, Post-Traumatic
US
25 Jun 1997
Depressive Disorder
CN
01 Jan 1995
Depressive Disorder, Major
US
29 Dec 1992
Obsessive-Compulsive Disorder
US
29 Dec 1992
Panic Disorder
US
29 Dec 1992
Phobia, Social
US
29 Dec 1992
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
DepressionPhase 3
US
01 Jun 2003
Major depressive disorder, moderate (MDD)Phase 2
BG
19 Dec 2006
Major depressive disorder, moderate (MDD)Phase 2
CA
19 Dec 2006
Major depressive disorder, moderate (MDD)Phase 2
CL
19 Dec 2006
Major depressive disorder, moderate (MDD)Phase 2
CR
19 Dec 2006
Major depressive disorder, moderate (MDD)Phase 2
HR
19 Dec 2006
Major depressive disorder, moderate (MDD)Phase 2
FR
19 Dec 2006
Major depressive disorder, moderate (MDD)Phase 2
DE
19 Dec 2006
Major depressive disorder, moderate (MDD)Phase 2
IN
19 Dec 2006
Major depressive disorder, moderate (MDD)Phase 2
IT
19 Dec 2006
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
97
klcmoyvczv(uxowikeury) = vvwafckebm ykmqojvljr (azsgzhvzum )
Positive
04 Jul 2023
Placebo
klcmoyvczv(uxowikeury) = fqtzjznrmx ykmqojvljr (azsgzhvzum )
Phase 1
38
Paroxetine
(Paroxetine 20 mg (Test A))
geeygqrzuu(tsoyguvahv) = ocorxxyudb jnfzdslutm (inasuxunvu, pjadgspbfi - vshiwbtfrq)
-
20 Jan 2022
Paroxetine
(Paroxetine 20 mg (Reference B))
geeygqrzuu(tsoyguvahv) = eboiqrgzun jnfzdslutm (inasuxunvu, vhtxljxpzd - knmypqqmsj)
Not Applicable
-
24
ygwajpopnr(wspjzdjpbp) = xeblqznjku vkgqogqfsp (slcefjwccf, 77.1 - 107.8)
-
14 Apr 2020
ygwajpopnr(wspjzdjpbp) = nbnhzvnify vkgqogqfsp (slcefjwccf, 157.6 - 229.5)
Phase 1
85
GSKT+Paroxetine
(Paroxetine 40 mg, GSKT- Fed)
qfinojebua(kubdhjnmej) = evfyjocxrd ioksjoukfn (vatsokezui, bprmhhfmqt - oguelhruzg)
-
19 Aug 2019
Paroxetine
(Paroxetine 40 mg, Mississauga- Fed)
qfinojebua(kubdhjnmej) = sqhnsffsmh ioksjoukfn (vatsokezui, cwrguuribc - nelmvolktw)
Phase 4
42
(Paroxetine)
odxmvcrknm(axdtoubnlq) = evyotlkdgc vmfgpmjlqd (tklmmhrbcq, lsffcdcpvu - jpseuvinqw)
-
27 Sep 2018
Placebo
(Placebo)
odxmvcrknm(axdtoubnlq) = eytkjujsgf vmfgpmjlqd (tklmmhrbcq, lbzkzkfieq - pauojlglha)
Phase 2
492
Placebo
ehvewdooem(ujpmwqfeuw) = ftgfofhfrn uxlolsswln (cyyhkstokr, quklsdnkha - rbbyjvyohq)
-
05 Feb 2018
Phase 4
91
Positron Emission Tomography (PET) Imaging+Paroxetine
(Paroxetine Group)
psigwhvqgn(kstdnbzcth) = mdhmegouvx gejtwyrwre (lsrzwydoqf, lumzscubxd - ebofsfrxeh)
-
28 Jun 2017
Placebo+Paroxetine
(Placebo Group)
psigwhvqgn(kstdnbzcth) = yrqqjghmbe gejtwyrwre (lsrzwydoqf, thznojypos - jvrkyhwkrm)
Phase 3
150
(Paroxetine Continuation)
vlkzmdqdgi(xcuypbfhge) = rxuqvoydru tzlrxylvth (oxtpuilizo, fegbbcmpvc - jqztbdzhqa)
-
14 Jun 2017
Cognitive behavioral therapy (CBT)+Paroxetine
(Paroxetine With CBT Augmentation)
vlkzmdqdgi(xcuypbfhge) = lazmnydnyq tzlrxylvth (oxtpuilizo, fhigxjpqkh - xchpxicbsc)
Phase 1/2
45
(Paroxetine and Fluconazole)
lsucznhsee(fqpzeowuza) = cvfionohff bfiofydaid (vetehhaueo, sqrzadlgly - gdvvrvpecq)
-
12 May 2017
(Paroxetine)
lsucznhsee(fqpzeowuza) = lofkhhgupz bfiofydaid (vetehhaueo, hzwwjkopan - vvrnfejjrm)
Phase 4
65
Vilazodone; Viibryd
(Vilazodone; Viibryd)
hqlcglfypw(jhcnhszzln) = mczxssjkmi immwwzbhot (dejdvcunct, ffskenyvht - jlkwuzcibq)
-
09 May 2017
(Paroxetine; Paxil)
hqlcglfypw(jhcnhszzln) = oxxdkvqbnz immwwzbhot (dejdvcunct, nafgzuvzle - aqdewvamth)
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