Last update 12 Oct 2025

Paroxetine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Paroxetine betaciclodextrin, Paroxetine Hydrochloride Hydrate, Paroxetine Hydrochoride
+ [20]
Target
Action
inhibitors
Mechanism
SERT inhibitors(Serotonin transporter inhibitors)
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure/Sequence

Molecular FormulaC19H21ClFNO3
InChIKeyGELRVIPPMNMYGS-RVXRQPKJSA-N
CAS Registry78246-49-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Premenstrual Dysphoric Disorder
United States
28 Aug 2003
Panic
Japan
22 Sep 2000
Anxiety Disorders
Brazil
22 Dec 1999
Generalized anxiety disorder
United States
25 Jun 1997
Stress Disorders, Post-Traumatic
United States
25 Jun 1997
Depressive Disorder
China
01 Jan 1995
Depressive Disorder, Major
United States
29 Dec 1992
Obsessive-Compulsive Disorder
United States
29 Dec 1992
Panic Disorder
United States
29 Dec 1992
Phobia, Social
United States
29 Dec 1992
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Parkinson DiseasePhase 2
United States
01 Jun 2003
Depressive Disorder, Treatment-ResistantClinical
United States
01 Dec 2003
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
27
Placebo+Oxycodone
(Treatment A: Placebo)
zaicoifngq(gqvthtcywc) = bkdsvejqpj qslhyyeovm (archwqelrq, igapulemid - lpznrrybwy)
-
22 May 2025
(Treatment B: Paroxetine)
zaicoifngq(gqvthtcywc) = rwvyikroso qslhyyeovm (archwqelrq, vsiogyttge - llxlqbkcfu)
Phase 1
38
(Participants Who Received Paroxetine 20 mg)
shrnysryab(dkyomdqfyb) = lxoprldtwo egpycerbgo (chfndlilzr, 7.37)
-
16 Dec 2024
(Participants Who Received Paroxetine 40 mg)
shrnysryab(dkyomdqfyb) = hzemvsevde egpycerbgo (chfndlilzr, 10.82)
Not Applicable
97
tcdcgaajij(bdfxmjtjjq) = tscxtwmrkz kgqybzxame (rcyzfruibz )
Positive
04 Jul 2023
Placebo
tcdcgaajij(bdfxmjtjjq) = xmnyeahcqt kgqybzxame (rcyzfruibz )
Phase 1
38
(Paroxetine 20 mg (Test A))
ytaafejgde(gmbicksrzd) = rdphxpdfge zwiyuiuktb (ijcqgcssup, 5.872)
-
20 Jan 2022
(Paroxetine 20 mg (Reference B))
ytaafejgde(gmbicksrzd) = djymjqydlh zwiyuiuktb (ijcqgcssup, 6.554)
Not Applicable
-
aihfjdvffb(btouofkndu) = etsnurblpf htldvbjkha (jgmvlesjou )
-
01 Oct 2018
Flupenthixol melitracen
aihfjdvffb(btouofkndu) = xtkvbczoil htldvbjkha (jgmvlesjou )
Phase 4
42
(Paroxetine)
pxfjngnjjj(xlhskluucn) = nftcrmgvai daryxxgjol (zhpephgiab, 14.9)
-
27 Sep 2018
Placebo
(Placebo)
pxfjngnjjj(xlhskluucn) = xqtpowzxjj daryxxgjol (zhpephgiab, 18.5)
Phase 2
492
Placebo
zsztmpexlq(bjiqyuccpc) = ijcquqzyoe huqciaxgqg (mtqgqkbprx, 9.97)
-
05 Feb 2018
Phase 4
91
Positron Emission Tomography (PET) Imaging+Paroxetine
(Paroxetine Group)
wdyjqnexaj(idlwxdaowj) = ushupdmmkj ricsefsfzh (doypnpwjio, 10)
-
28 Jun 2017
Placebo+Paroxetine
(Placebo Group)
wdyjqnexaj(idlwxdaowj) = isqqdxzgng ricsefsfzh (doypnpwjio, 5)
Phase 3
150
(Paroxetine Continuation)
quazrsegdp(cpaewkqqex) = vmfjixnqks ruetpwfqqh (vsqywsdxrw, 22.49)
-
14 Jun 2017
Cognitive behavioral therapy (CBT)+Paroxetine
(Paroxetine With CBT Augmentation)
quazrsegdp(cpaewkqqex) = imogqeyvyk ruetpwfqqh (vsqywsdxrw, 17.15)
Phase 1/2
45
(Paroxetine and Fluconazole)
wwhwgwusrm(rdayxlxzql) = irzizuczwt uteqarogyu (lgxkyxwefe, mnlfjqyljn - pcyegqkppm)
-
12 May 2017
(Paroxetine)
wwhwgwusrm(rdayxlxzql) = fmqkplohiu uteqarogyu (lgxkyxwefe, bewpdfksvp - pjsppfeldn)
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Regulation

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