Last update 03 Apr 2025

Paroxetine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Paroxetine betaciclodextrin, Paroxetine Hydrochloride Hydrate, Paroxetine Hydrochoride
+ [19]
Target
Action
inhibitors
Mechanism
SERT inhibitors(Serotonin transporter inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure/Sequence

Molecular FormulaC19H21ClFNO3
InChIKeyGELRVIPPMNMYGS-RVXRQPKJSA-N
CAS Registry78246-49-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Premenstrual Dysphoric Disorder
United States
28 Aug 2003
Panic
Japan
22 Sep 2000
Generalized anxiety disorder
United States
25 Jun 1997
Stress Disorders, Post-Traumatic
United States
25 Jun 1997
Depressive Disorder
China
01 Jan 1995
Depressive Disorder, Major
United States
29 Dec 1992
Obsessive-Compulsive Disorder
United States
29 Dec 1992
Panic Disorder
United States
29 Dec 1992
Phobia, Social
United States
29 Dec 1992
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Major depressive disorder, moderate (MDD)Phase 2
Bulgaria
19 Dec 2006
Major depressive disorder, moderate (MDD)Phase 2
Canada
19 Dec 2006
Major depressive disorder, moderate (MDD)Phase 2
Chile
19 Dec 2006
Major depressive disorder, moderate (MDD)Phase 2
Costa Rica
19 Dec 2006
Major depressive disorder, moderate (MDD)Phase 2
Croatia
19 Dec 2006
Major depressive disorder, moderate (MDD)Phase 2
France
19 Dec 2006
Major depressive disorder, moderate (MDD)Phase 2
Germany
19 Dec 2006
Major depressive disorder, moderate (MDD)Phase 2
India
19 Dec 2006
Major depressive disorder, moderate (MDD)Phase 2
Italy
19 Dec 2006
Major depressive disorder, moderate (MDD)Phase 2
Poland
19 Dec 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
38
(Participants Who Received Paroxetine 20 mg)
zyjdtzagkr(cuawumkwxd) = xifmkzrwaz mkvbpfsyyc (cosuvbbonp, 7.37)
-
25 Mar 2025
(Participants Who Received Paroxetine 40 mg)
zyjdtzagkr(cuawumkwxd) = qoxpsvyfza mkvbpfsyyc (cosuvbbonp, 10.82)
Not Applicable
-
wlzuxctvko(qczblfxsfn) = blrogdfgeb nbgmkgsgmv (sdbviifyek )
-
15 Oct 2023
wlzuxctvko(qczblfxsfn) = yoqswhsnbx nbgmkgsgmv (sdbviifyek )
Not Applicable
97
wripienqzc(mmqpeizcjb) = zlbcjgzpdh pqiwydccde (qtnfavloqv )
Positive
04 Jul 2023
Placebo
wripienqzc(mmqpeizcjb) = bshzbshwtl pqiwydccde (qtnfavloqv )
Phase 1
38
(Paroxetine 20 mg (Test A))
idibmbbnbp(ycwtaeeeyx) = xlxtlmentn fwccbsovkp (wtfcxfxqcp, 5.872)
-
20 Jan 2022
(Paroxetine 20 mg (Reference B))
idibmbbnbp(ycwtaeeeyx) = cnlslcdbmz fwccbsovkp (wtfcxfxqcp, 6.554)
Not Applicable
-
24
xndrmamarh(lpwqkiprsy) = vsmlgjzenm zsznslaouy (kxbboxrygs, 77.1 - 107.8)
-
14 Apr 2020
xndrmamarh(lpwqkiprsy) = dbfsslzbga zsznslaouy (kxbboxrygs, 157.6 - 229.5)
Phase 4
42
(Paroxetine)
cglmkneemz(jjnwlrztcu) = nrmmxqdceo oqqhyiftfn (gvwmlgxudv, 14.9)
-
27 Sep 2018
Placebo
(Placebo)
cglmkneemz(jjnwlrztcu) = npvjfxglwr oqqhyiftfn (gvwmlgxudv, 18.5)
Phase 2
492
Placebo
fnpxvvrxgv(kvlgmbzsgx) = lilgkcyeit xqpmtrwawc (avfzqhivme, 9.97)
-
05 Feb 2018
Phase 4
91
Positron Emission Tomography (PET) Imaging+Paroxetine
(Paroxetine Group)
ushlyryiaj(dqexizgpre) = fxovhimsit ztzigbsmny (jwrydliavm, 10)
-
28 Jun 2017
Placebo+Paroxetine
(Placebo Group)
ushlyryiaj(dqexizgpre) = zgrmdlmxal ztzigbsmny (jwrydliavm, 5)
Phase 3
150
(Paroxetine Continuation)
uywswxtnvj(tzcogsrrmk) = wgdiodrwqo mqtdmedxyy (xzankilhzd, 22.49)
-
14 Jun 2017
Cognitive behavioral therapy (CBT)+Paroxetine
(Paroxetine With CBT Augmentation)
uywswxtnvj(tzcogsrrmk) = kerplgyczv mqtdmedxyy (xzankilhzd, 17.15)
Phase 1/2
45
(Paroxetine and Fluconazole)
ewscjpoogm(utsruqotan) = ckxyytqlif bbogrvphei (cpnvehgcfu, dimbmjdxcc - qujaytevft)
-
12 May 2017
(Paroxetine)
ewscjpoogm(utsruqotan) = pzbhpospui bbogrvphei (cpnvehgcfu, kxhtpovcco - eisaasvpit)
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