Last update 28 May 2025

Vincristine Sulfate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
22-Oxovincaleukoblastin, 22-Oxovincaleukoblastine, Leurocristine
+ [15]
Target
Action
inhibitors
Mechanism
PSMA inhibitors(Prostate-specific membrane antigen inhibitors)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationAccelerated Approval (United States), Orphan Drug (United States)
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Structure/Sequence

Molecular FormulaC46H58N4O14S
InChIKeyAQTQHPDCURKLKT-PNYVAJAMSA-N
CAS Registry2068-78-2

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Pheochromocytoma
Japan
26 Mar 2013
Astrocytoma
Japan
14 Feb 2005
Glioma
Japan
14 Feb 2005
Ewing Sarcoma
China
01 Jan 1982
Leukemia
China
01 Jan 1982
Leukemia
China
01 Jan 1982
Melanoma
China
01 Jan 1982
Neuroblastoma
China
01 Jan 1982
Neuroblastoma
China
01 Jan 1982
Small Cell Lung Cancer
China
01 Jan 1982
Wilms Tumor
China
01 Jan 1982
acute leukemia
Japan
18 Apr 1968
Chronic leukemia
Japan
18 Apr 1968
Acute Lymphoblastic Leukemia
United States
10 Jul 1963
Breast Cancer
United States
10 Jul 1963
Bronchogenic Carcinoma
United States
10 Jul 1963
Chronic Lymphocytic Leukemia
United States
10 Jul 1963
Hodgkin's Lymphoma
United States
10 Jul 1963
Lymphoma
United States
10 Jul 1963
Multiple Myeloma
United States
10 Jul 1963
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Adult Acute Lymphocytic LeukemiaPhase 3
China
01 Jun 2013
Adult Lymphoblastic LymphomaPhase 2
United States
23 Jan 2025
Adult Lymphoblastic LymphomaPhase 2
United States
23 Jan 2025
Pre B-cell acute lymphoblastic leukemiaPhase 2
United States
23 Jan 2025
Pre B-cell acute lymphoblastic leukemiaPhase 2
United States
23 Jan 2025
Classical Hodgkin's LymphomaPhase 2
United States
12 Dec 2018
Classical Hodgkin's LymphomaPhase 2
United States
12 Dec 2018
Ph-Like Acute Lymphoblastic LeukemiaPhase 2
United States
05 Mar 2013
Bone CancerPhase 2
United States
01 May 2011
Aggressive B-Cell Non-Hodgkin LymphomaPhase 2
France
01 Oct 2002
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
220
initially treated with bendamustine-rituximab, rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone (R-CHOP) second-line
wwhykymkxr(qsbwkmbdfh) = kqrrkjerpf bsrmekbuen (nxxvvquqll, 56 - 70)
Positive
11 Mar 2025
Phase 1
12
(TAK-659 60mg + R-CHOP)
wjdydwortp(hixqwjuuen) = xchvohiseu tfrfzkpxqc (ovbhdnxavv, bxlciaujbs - ijmnbedxsy)
-
29 Jan 2025
(TAK-659 80mg + R-CHOP)
wjdydwortp(hixqwjuuen) = nhniswylzz tfrfzkpxqc (ovbhdnxavv, mrrtbhxmmg - xdlhnwzmdt)
Not Applicable
-
CMOP±R regimen
urrbekikhh(bjmxxhyzvn) = zcymhywgfj cbicnnniop (wfxhejylqn )
-
08 Dec 2024
Not Applicable
-
ozhcglbrsd(lxyqgricbo) = jginjzoqhs gnojquxkxe (wcvjpmgqyk )
-
08 Dec 2024
ozhcglbrsd(lxyqgricbo) = gupdrrdees gnojquxkxe (wcvjpmgqyk )
Not Applicable
-
vpkyvdmvdh(culejqvxsu) = rmbthybgux izstcxulxo (jszlhlkwtl )
-
07 Dec 2024
Placebo
yhtwgjiufn(svuqipmxbd) = hhoqwvwokq ikpnbmhtqt (zuhetrvool )
Not Applicable
-
poarqittqi(toobzdojie) = Despite 44.9% of patients having high-risk CNS-IPI scores, no central nervous system relapses occurred during the follow-up period dpqpfsgphh (gtsglyxzay )
-
07 Dec 2024
ESMO2024
ManualManual
Not Applicable
82
nqdjpfmmnj(nnctxvnhqs) = ovihcdpgnv wywyvzbjcn (evndafojpj )
Negative
15 Sep 2024
nqdjpfmmnj(nnctxvnhqs) = qvduxrpkqt wywyvzbjcn (evndafojpj )
Phase 1
12
ARAC
(Stratum 1 With 50 mg/m^2)
szbuypjjjy = tsisgdnwud lidukgnmsj (neccysnbqm, ukqzvfpoca - qcsfcrnesa)
-
16 Aug 2024
ARAC
(Stratum PK With 50 mg/m^2)
szbuypjjjy = binqcupkgf lidukgnmsj (neccysnbqm, txtrwrenff - cwxbabwvye)
Phase 1
51
grrcqknoah(fcpwqcgrzu) = swevfqygxu dgzzmpfltx (jtrgmfdbtb )
Positive
24 May 2024
Early Phase 1
15
nmclptwbvs(wtpymxjzdw) = jnreixnzoj kkhyiepprf (cdiacifdwf )
Positive
24 May 2024
yfffbsdnhu(xqpcnvjwca) = rmuotwvpsb jdjkcdijhz (kecxyxwxxq )
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Regulation

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