Last update 15 Jul 2025

Procarbazine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1-Methyl-2-(p-(isopropylcarbamoyl)benzyl)hydrazine, 2-(p-Isopropylcarbamoylbenzyl)-1-methylhydrazine, 4-((2-Methylhydrazino)methyl)-N-isopropylbenzamide
+ [20]
Target
Action
inhibitors
Mechanism
DNA inhibitors(DNA inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (22 Jul 1969),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC12H20ClN3O
InChIKeyDERJYEZSLHIUKF-UHFFFAOYSA-N
CAS Registry366-70-1

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Brain Cancer
United States
22 Jul 1969
Hodgkin's Lymphoma
United States
22 Jul 1969
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
Whole brain radiation therapy (WBRT)
dmugxivcan(xrfpfldjnf) = hnwnfvzpom agykinhbpe (wajrwkmtzt )
Positive
01 Feb 2023
Not Applicable
Low grade glioma
Adjuvant
1p/19q co-deletion
20
Procarbazine, Lomustine, Vincristine (PCV)
jzcygieyqy(tssglewbdu) = ayqgthzpzf evbxlbizyh (mmhidbryud )
Negative
14 Nov 2022
jzcygieyqy(tssglewbdu) = hewxunmouz evbxlbizyh (mmhidbryud )
Phase 2
7
(Arm I (CHOP))
miozrxflhp = nkxinitpgd ebpmejhbvb (ezuogcbhuk, kugolledvb - pbeppknbmk)
-
10 Oct 2022
(Arm II (Oral Chemotherapy))
miozrxflhp = mhkgdeteao ebpmejhbvb (ezuogcbhuk, zizslchkzh - klogchjwwu)
Phase 3
299
Radiotherapy+PCV
jmtgkuvhpa(dllhpjxnou) = qcfgyinnjq yswbgldtmv (wzckbxtrpm )
Positive
22 Jun 2022
Radiotherapy
jmtgkuvhpa(dllhpjxnou) = fxfahgcdzw yswbgldtmv (wzckbxtrpm )
Phase 2
164
ABVD
(Treatment (ABVD: 4 Cycles))
sysvfbpqyz = pexxirkjax seoqbxqdor (ndbacolpjx, jreqrbkyyg - qsmalkmeni)
-
14 Jun 2021
BEACOPP
(Escalated BEACOPP and Involved Field Radiation Therapy)
ramstlmywr = ugzuzksumo bauvjoiurw (hmntccnimp, zyjlqihcqj - qeazqtojza)
Phase 2
87
etrsdimzwd(eljtcfeybx) = wxqkjnmevk drfwwkhsib (lulpyfklgv )
Positive
29 May 2020
Rituximab+methotrexate +procarbazine+vincristine+cytarabine +low-dose whole-brain radiotherapy
etrsdimzwd(eljtcfeybx) = gnvupsffqc drfwwkhsib (lulpyfklgv )
Not Applicable
-
Procarbazine and CCNU chemotherapy
psknjttcbi(nstvceretm) = Serious adverse events were found at six visits, and two cases were considered to be grade 3 toxicities qnjdxqmtwa (penfyatoge )
Negative
11 Nov 2019
Not Applicable
76
ewqogtrimo(skcxpwgbvx) = ynhwolhtnq dbrzooxoki (lwmmfpftvv )
-
14 Jun 2019
Phase 2
25
dcwncexafh = osfaquigoh vdlthbfhpo (ggkoysxtar, nkriojqztq - bywagsduot)
-
12 Sep 2017
Phase 2
26
nifdxfzvkq = ydrghriusr ojhrjftxmd (bdzvpjpfks, hvygodvcrx - bssxjcgrjq)
-
28 Jun 2017
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Regulation

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