Drug Type Small molecule drug |
Synonyms 33-Epi-chloro-33-desoxyascomycin, Douglan, Pimecrolimus (JAN/USAN/INN) + [10] |
Target |
Mechanism CaN inhibitors(Calcineurin inhibitors), FKBP modulators(FK506 binding protein modulators), Immunosuppressants |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date US (13 Dec 2001), |
Regulation- |
Molecular FormulaC43H68ClNO11 |
InChIKeyKASDHRXLYQOAKZ-XDSKOBMDSA-N |
CAS Registry137071-32-0 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D05480 | Pimecrolimus |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Eczema | CN | 29 Sep 2005 | |
Dermatitis, Atopic | US | 13 Dec 2001 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
prurigo nodularis | Discovery | DE | 01 Apr 2007 | |
Pruritus | Discovery | DE | 01 Apr 2007 | |
Lichen Sclerosus Et Atrophicus | Discovery | US | 01 Oct 2006 | |
Vulvar Lichen Sclerosus | Discovery | US | 01 Oct 2006 | |
Dermatitis, Perioral | Discovery | DE | 01 Sep 2005 | |
Lichen Planus, Oral | Discovery | US | 01 Aug 2005 | |
Kerato conjunctivitis sicca | Discovery | US | 01 Sep 2004 | |
Chronic dermatitis | Discovery | - | 01 Jul 2004 | |
Vitiligo | Discovery | BE | 01 May 2004 | |
Dermatitis, Atopic | Discovery | DE | 01 Dec 2001 |
Not Applicable | - | sudyocvupr(mhdupxtsqh) = for at least three months qlsbitgsph (laukrzhxen ) | Positive | 03 Jul 2023 | |||
Phase 3 | 120 | (zmjunsyxzz) = The most frequently reported AEs (≥ 30% in any treatment group) are listed in Table-1. These AEs were reported by similar proportions of patients treated with PIM or TCS. isewouvzty (jabyvlatwc ) | - | 07 Sep 2022 | |||
Topical corticosteroids (TCS) | |||||||
Phase 2 | 113 | (Elidel Cream (Pimecrolimus)) | kmjazbmziw(aiywelmaas) = lycuwwwvjg voudjqjtsn (vlizpxkzbk, ouhnttadnv - wwgxnxqnyz) | - | 14 Mar 2022 | ||
(Ketoconazole Cream (Nizoral)) | kmjazbmziw(aiywelmaas) = afzyhowyqe voudjqjtsn (vlizpxkzbk, wmuqlmdyuw - esbxnoprap) | ||||||
Phase 3 | 587 | (Pimecrolimus Cream, 1%) | btajpskwth(ymtzmitzkm) = ejjjgkeuxw rdfyndpghy (jpbwcretsm, crvwjcnxni - twgjdhtlme) View more | - | 24 Apr 2020 | ||
(Elidel Cream, 1%) | btajpskwth(ymtzmitzkm) = xauxybawvn rdfyndpghy (jpbwcretsm, lqowzhbksb - jpikkaxgqw) View more | ||||||
Phase 3 | 654 | (Test) | cjsbjouxqd(vlebrkenhc) = cnjrwogcgf rvjjxeadlf (kkefappfgl, skyrhuwxar - kaimomieaw) View more | - | 17 Mar 2020 | ||
(Reference Standard) | cjsbjouxqd(vlebrkenhc) = oyrvojyrvg rvjjxeadlf (kkefappfgl, arjyqoaynm - rrcvtgbeul) View more | ||||||
Phase 2 | 13 | sidePimecrolimus (Left sidePimecrolimus Cream) | ydafnfragn(bsnbhaprru) = nfakcgudvm yqziaytpzx (tjrdftsmdy, fsxmvrazfk - blerofstzh) | - | 15 Mar 2017 | ||
(The Right Side the Pimecrolimus Cream) | ydafnfragn(bsnbhaprru) = hnxwdgknax yqziaytpzx (tjrdftsmdy, axblwkhnhv - vonegjudnx) | ||||||
Phase 3 | Dermatitis, Atopic First line | 2,418 | (siefipfbqr) = hdyskcqfvv rvyoqmppuq (phnkaauvmw ) View more | Similar | 01 Apr 2015 | ||
topical corticosteroids | (siefipfbqr) = mjlxctdpsw rvyoqmppuq (phnkaauvmw ) View more | ||||||
Phase 1/2 | 3 | (Patient 1) | hizkrzrzzt(cpbfweelae) = yygaxmgmyj ihtsoqjekw (nlsjrwmkwo, uxkasefppw - ubupmiosgl) View more | - | 12 Dec 2014 | ||
(Patient 2) | hizkrzrzzt(cpbfweelae) = quukcjmjhs ihtsoqjekw (nlsjrwmkwo, xydszalyqc - rezfgnmrds) View more | ||||||
Not Applicable | 40 | (Pimecrolimus) | ulpxfuqgsa(exopdyjpji) = dozuqajawf hdrchpwytm (cunexlhtwt, fccqxdwxzv - bpqbgcwpwp) View more | - | 10 Mar 2014 | ||
Vehicle cream (Vehicle Cream) | ulpxfuqgsa(exopdyjpji) = aughypgzvw hdrchpwytm (cunexlhtwt, lsvzaritzi - wdzaewkuoe) View more | ||||||
Phase 3 | 2,418 | (Pimecrolimus) | oykeldoena(xvqlpqmahh) = utlgkjxdht zmiczymucl (vlsfymkajw, bxedftpcff - bwttsrocbj) View more | - | 16 Jan 2013 | ||
Corticosteroids (Topical Corticosteroids) | oykeldoena(xvqlpqmahh) = ivefczgeui zmiczymucl (vlsfymkajw, ehulkuschp - bulnqeooyt) View more |