A Multicenter, Extension Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Two Doses of Linsitinib in Subjects With Active, Moderate to Severe Thyroid Eye Disease (TED)

The overall study objective is to continue to assess the efficacy, safety, pharmacokinetics, and pharmacodynamics of linsitinib in subjects who were enrolled in the prior VGN-TED-301 through Week 24. These subjects include VGN-TED-301 Week 24 proptosis non-responders or subjects who relapse during the Follow-Up Period of VGN-TED-301.

Start Date11 Oct 2023

Sponsor / Collaborator

Sling Therapeutics, Inc.

NCT05276063

/ Active, not recruitingPhase 2/3

A Phase 2b, Randomized, Double-Mask, Placebo-Controlled, Study to Evaluate the Safety, Pharmacokinetics and Efficacy of Linsitinib in Subjects With Active, Moderate to Severe Thyroid Eye Disease (TED)

The overall objective is to study the safety, pharmacokinetics and efficacy of linsitinib (a small molecule IGF-1R inhibitor) administered orally twice daily (BID) vs. placebo, at 24 weeks in the treatment of subjects with active, moderate to severe thyroid eye disease (TED).

Start Date01 Jul 2022

Sponsor / Collaborator

Sling Therapeutics, Inc.

NCT02057380

/ CompletedPhase 2

A Phase II Open-label Rollover Study for Subjects That Have Participated in an Astellas Sponsored Linsitinib Trial

The purpose of this study is to provide access to continued treatment for subjects who participated in other Astellas sponsored trials and for whom the investigator feels the subject may benefit from continued treatment.

Start Date16 Apr 2014

Sponsor / Collaborator

Astellas Pharma Global Development, Inc.

100 Clinical Results associated with Linsitinib

100 Translational Medicine associated with Linsitinib

100 Patents (Medical) associated with Linsitinib

344

Literatures (Medical) associated with Linsitinib

01 Sep 2025·NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Bioinformatics-based identification of mirdametinib as a potential therapeutic target for idiopathic pulmonary fibrosis associated with endoplasmic reticulum stress

Article

Author: Luo, Tingyue ; Dong, Hangming ; Cai, Shaoxi ; Zhang, Jinming ; Yu, Qi ; Chen, Junwei ; Huang, Haohua ; Du, Yuhan ; Liu, Dongyu

The molecular link between endoplasmic reticulum stress (ERS) and idiopathic pulmonary fibrosis (IPF) remains elusive. Our study aimed to uncover core mechanisms and new therapeutic targets for IPF. By analyzing gene expression profiles from the Gene Expression Omnibus (GEO) database, we identified 1519 differentially expressed genes (DEGs) and 11 ERS-related genes (ERSRGs) diagnostic for IPF. Using weighted gene co-expression network analysis (WGCNA) and differential expression analysis, key genes linked to IPF were pinpointed. CIBERSORT was used to assess immune cell infiltration, while the Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed to explore biological mechanisms. In three GEO datasets (GSE150910, GSE92592, and GSE124685), the receiver operating characteristic (ROC) curve analysis showed area under the ROC curve (AUC) > 0.7 for all ERSRGs. The Connectivity Map (CMap) database was used to predict small molecules modulating IPF signatures. The molecular docking energies of mirdametinib with protein targets ranged from - 5.1643 to - 8.0154 kcal/mol, while those of linsitinib ranged from - 5.6031 to - 7.902 kcal/mol. Molecular docking and animal experiments were performed to validate the therapeutic potential of identified compounds, with mirdametinib showing specific effects in a murine bleomycin-induced pulmonary fibrosis model. In vitro experiments indicated that mirdametinib may alleviate pulmonary fibrosis by reducing ERS via the PI3K/Akt/mTOR pathway. Our findings highlight 11 ERSRGs as predictors of IPF and demonstrate the feasibility of bioinformatics in drug discovery for IPF treatment.

01 Aug 2025·CELL BIOLOGY INTERNATIONAL

Epigallocatechin‐3‐Gallate Attenuates Benign Prostatic Hyperplasia Development via Regulating Firmicutes to Inhibit Gastric Secretion of Insulin‐Like Growth Factor‐1

Article

Author: Liu, Chong ; Shao, YiQun ; Yang, Tianye ; Wang, Zhong ; Gu, Meng

ABSTRACT:

Benign prostatic hyperplasia (BPH), a prevalent age‐related condition in men, is increasingly linked to metabolic syndrome (MetS) and gut microbiota dysbiosis. This study reveals how Firmicutes‐dominant microbial imbalance drives BPH progression via IGF‐1 signaling and identifies the green tea polyphenol epigallocatechin‐3‐gallate (EGCG) as a dual‐action therapeutic. Using MetS‐BPH mouse models and human prostate cell lines, we demonstrated that BPH‐associated gut microbiota—particularly elevated Firmicutes and an increased Firmicutes/Bacteroidetes ratio—promotes prostate hyperplasia by upregulating IGF‐1. Both BPH mice and recipient mice transplanted with BPH microbiota showed elevated serum and prostate IGF‐1 levels, mirroring findings in human BPH patients. Mechanistically, IGF‐1 stimulated prostate cell proliferation (RWPE‐1/WPMY‐1) and suppressed apoptosis via PI3K/AKT/mTOR activation, while the IGF‐1 antagonist Linsitinib reversed these effects. EGCG emerged as a potent modulator of this gut‐prostate axis: it selectively reduced Firmicutes overgrowth in BPH mice, normalized IGF‐1 levels, and inhibited downstream PI3K/AKT/mTOR signaling. In fecal microbiota transplantation experiments, EGCG counteracted IGF‐1‐driven prostate enlargement and microbial dysbiosis, underscoring its dual role in rebalancing gut flora and blocking growth factor pathways. Our findings position EGCG as a promising intervention for MetS‐associated BPH, simultaneously targeting microbial dysbiosis and IGF‐1 signaling. This study not only elucidates the Firmicutes–IGF‐1 axis in BPH pathogenesis but also highlights the therapeutic potential of dietary polyphenols in metabolic urological disorders.

01 Aug 2025·INTERNATIONAL IMMUNOPHARMACOLOGY

Targeting insulin-like growth factor 1 signaling with Linsitinib to modulate fibroblast plasticity and attenuate pulmonary fibrosis

Article

Author: Pan, Maojie ; Xu, Yangjun ; Chen, Zhile ; Chen, Chun ; Jin, Binqian ; Ding, Qiannan ; Zhang, Chu ; Zhu, Ting ; Yu, Guangmao ; Ding, Jianyi ; Yang, Luping ; Li, Zhupeng ; Wang, Bin

Idiopathic pulmonary fibrosis (IPF) is a fatal, irreversible lung disorder with limited treatment options. Pathogenic drivers include fibroblast-to-myofibroblast transition, excessive collagen deposition, and inflammatory infiltration. Elevated circulating insulin-like growth factor-1 (IGF-1) levels and dysregulated activation of the IGF-1 receptor (IGF-1R) are implicated in multiple pathological conditions such as cancer, chronic inflammation, and fibrotic diseases. Linsitinib, a small-molecule tyrosine kinase inhibitor, selectively targets IGF-1R activation. However, its therapeutic potential and pharmacological mechanisms in IPF remain unexplored. In this study, we aimed to evaluate the efficacy and molecular basis of Linsitinib for IPF treatment. High-throughput sequencing revealed IGF-1 upregulation in the lung tissues of a murine IPF model. In vivo, oral Linsitinib attenuated fibrosis and inflammation in bleomycin-induced pulmonary fibrosis, inhibiting IGF-1R phosphorylation. In vitro, Linsitinib suppressed transforming growth factor β1-induced fibroblast-to-myofibroblast transition (marked by reduced alpha smooth muscle actin and fibronectin) and collagen biosynthesis (COL1A1, COL3A1) in primary lung fibroblasts. Transcriptomic profiling and lentiviral-based functional assays demonstrated that Linsitinib upregulated peroxisome proliferator-activated receptor gamma (PPARγ) expression by blocking IGF-1R phosphorylation, thereby promoting adipogenic transdifferentiation. Ex vivo, human IPF lung explants confirmed Linsitinib mitigated fibrosis and collagen accumulation via the IGF-1/IGF-1R/PPARγ axis. These findings suggest that Linsitinib exerts its effects against fibrosis by targeting IGF-1R-driven signaling pathways, making it a potential therapeutic agent for IPF.

News (Medical) associated with Linsitinib

14 Jan 2025

·www.fiercebiotech.com

Sling\'s oral Tepezza rival hits goal in thyroid eye disease, setting stage for confirmatory phase 3

Convenience is one area Sling Therapeutics may have an edge over the incumbent in thyroid eye disease. \n Sling Therapeutics’ oral challenger to Amgen’s intravenous Tepezza has hit the mark in a phase 2b/3 thyroid eye disease (TED) trial, teeing the biotech up to run a confirmatory study of its ex-Astellas asset. But a cross-trial comparison suggests Amgen’s blockbuster may have the advantage on the efficacy front.Astellas studied the small-molecule IGF-1R inhibitor linsitinib as a cancer treatment. However, with the anti-IGF-1R antibody Tepezza showing the benefits of targeting the receptor in TED, Sling spied a chance to use linsitinib in the eye disease. The biotech launched with $35 million to run a phase 2b trial in TED, a complication of Graves’ disease that causes the eyes to bulge, in 2022.About 18 months later, Sling has evidence linsitinib works in TED. Investigators randomized 90 patients to receive one of two doses of linsitinib or placebo. After 24 weeks, 52% of people on the high dose had a big enough reduction in eye bulging to meet the response criteria.The response rate was significantly higher than in the placebo group, causing the high dose to achieve the primary endpoint. Sling made no mention of the performance of the low dose. The biotech is now preparing to start a confirmatory phase 3 trial this year. Horizon Therapeutics, which brought Tepezza to market before selling up to Amgen, reported a higher response rate in its phase 3 program. After eight infusions across 24 weeks, the response rates in the two Tepezza trials were (PDF) 71% and 83%. Cross-trial comparisons can be misleading, but the available data suggest Sling may need to focus on areas other than efficacy to compete.Convenience is one area Sling may have an edge over the incumbent. Tepezza patients receive 60- to 90-minute infusions every three weeks. Linsitinib is taken orally twice a day. Amgen began a phase 3 trial of a subcutaneous formulation of Tepezza last year, positioning it to potentially free patients from lengthy infusions in the future.Safety and tolerability is another potential battleground. In Tepezza’s phase 3 program, 10% of patients on the drug developed hearing impairment, a catch-all term for conditions such as deafness and tinnitus. Sling said no drug-related hearing impairment was reported in its trial, although there was one unrelated report, and the placebo-adjusted tinnitus rate was 0%. Hyperglycemia was rarer than for Tepezza, too.Sling saw elevated liver enzymes, but they resolved quickly and caused no signs of drug-induced injury, leading the biotech to conclude linsitinib was well tolerated. The planned phase 3 trial will shed more light on the molecule’s safety and efficacy profile and potentially position Sling to challenge Amgen for the TED market.

$Sling\'s oral Tepezza rival hits goal in thyroid eye disease, setting stage for confirmatory phase 3$

Phase 3Clinical ResultPhase 2

14 Jan 2025

·www.prnewswire.com

Sling Therapeutics Announces Positive Topline Results from Phase 2b/3 LIDS Clinical Trial of Oral Small Molecule Linsitinib in Patients with Thyroid Eye Disease

- Linsitinib is the first and only oral small molecule therapy to establish statistical and clinical significance in Thyroid Eye Disease (TED) - Phase 2b/3 LIDS trial met primary endpoint of proptosis reduction with statistical significance at 150mg BID dose - Linsitinib was well-tolerated particularly in IGF-1R areas of interest such as hearing impairment, glycemic changes, and menstrual cycle changes - Confirmatory Phase 3 trial on track to commence in 2025 ANN ARBOR, Mich., Jan. 14, 2025 /PRNewswire/ -- Sling Therapeutics, Inc., a late-stage biopharmaceutical company focused on the development of an oral small molecule for the treatment of thyroid eye disease (TED), today announced topline efficacy and safety data from the Phase 2b/3 LIDS trial of linsitinib in patients with active, moderate to severe TED. Linsitinib, Sling's lead product candidate, is a convenient oral small molecule, taken twice-daily, in clinical development for TED. Linsitinib works by inhibiting the validated IGF-1R target and has an established safety profile through treatment of more than 900 patients across fifteen clinical trials in multiple disease areas. "The positive data from this trial establish the clinical significance of linsitinib and represent the first ever successful clinical trial of an oral small molecule for the treatment of TED," said Ryan Zeidan, Ph.D., President and Chief Executive Officer of Sling Therapeutics. "We believe linsitinib can be a potential new treatment option that could enable a broader number of physicians across multiple therapeutic disciplines to treat patients diagnosed with TED. We are excited to continue our clinical program and are on track to initiate our confirmatory Phase 3 registrational trial later this year." Trial Overview and Topline Results The LIDS Phase 2b/3, randomized, double-masked, placebo-controlled study was designed to evaluate the safety, pharmacokinetics, and efficacy of linsitinib in patients with active, moderate to severe TED. The primary endpoint of the study was the percentage of subjects who were proptosis responders at week 24, defined as at least a two-millimeter reduction in proptosis from baseline. The LIDS trial enrolled 90 patients who were randomized 1:1:1 and received either linsitinib 150mg BID, linsitinib 75mg BID, or placebo for 24 weeks. The trial was conducted globally at 35 sites in five countries. The LIDS trial met its primary endpoint with statistical significance for the 150mg BID dose. Linsitinib in this trial validated the safety profile seen in the prior oncology studies and importantly demonstrated a favorable safety profile on key adverse events (AEs) of interest for the IGF-1R target such as hearing impairment, hyperglycemia, and menstrual cycle changes. Additionally, no QTc prolongation was observed in any patient with rigorous ECG monitoring throughout the study. Key Topline Data: Statistically Significant Proptosis Responder Rate (PRR): PRR was statistically significant and clinically meaningful at the 150mg BID dose, with a PRR of 52% (p = 0.01) at Week 24. Consistent Safety Data, No Drug-Related Hearing Impairments: Linsitinib was well-tolerated and consistent with the safety profile of the previous 15 linsitinib clinical trials, which now includes more than 900 patients in multiple disease areas. Key AE data from the 150mg BID arm include: No drug-related hearing impairment reported (1 unrelated report out of 29 patients) 0% tinnitus placebo-adjusted rate 3% rate of hyperglycemia (1 report out of 29 patients with no intervention required) 0% menstrual cycle changes reported Treatment emergent AEs greater than or equal to 10%: diarrhea (20.7%), headache (20.7%), nausea (20.7%), fatigue (17.2%), ALT increase (17.2%), hyperhidrosis (13.8%), AST increase (10.3%), and muscle spasms (10.3%) Hepatic transaminases were all quickly resolved and not associated with any elevations of total bilirubin, alkaline phosphatase, hepatic dysfunction, or other signs or symptoms of drug-induced liver injury The majority of AEs were either mild or moderate, reversible, and quickly resolved upon treatment pause or discontinuation consistent with a shorter half-life treatment No QTc prolongation was observed in any patient with rigorous monitoring throughout the study "TED is a debilitating auto-immune disorder with limited options available for patients today. Patients must currently choose between an invasive orbital surgery or eight infusions over 24 weeks, which can be inconvenient and time-consuming and pose serious potential risks," said Raymond Douglas, M.D., Ph.D., Professor at Cedars-Sinai Medical Center and KOL and lead investigator in previous TED trials, as well as Chief Scientific Officer at Sling Therapeutics. "In this trial, patients demonstrated significant improvement in disease with no drug-related hearing impairments or significant hyperglycemia. These side effects are the largest barriers for current medical treatments, making linsitinib an important potential new therapy for patients with TED. As a practicing physician, it makes sense to start a new patient's treatment journey with an oral therapy that shows an early response that increases over time." The Company is engaging with regulatory authorities to discuss the confirmatory Phase 3 trial design, which is on track to commence in 2025. Full results of this Phase 2b/3 trial will be presented at an upcoming medical conference. About Linsitinib Linsitinib is a convenient oral small molecule, taken twice-daily and with a short half-life, in clinical development for thyroid eye disease (TED). Linsitinib works by inhibiting the IGF-1R target, which is the only validated clinical target in TED and the only target for current FDA-approved therapies. Activation of the IGF-1R target leads to inflammation and proptosis seen in TED. Linsitinib has an established safety profile through treatment of more than 900 patients in fifteen clinical trials in multiple diseases. About Thyroid Eye Disease (TED) Thyroid Eye Disease (TED) is a serious, progressive, and vision-threatening rare autoimmune disease that affects approximately 70,000 people in the U.S. and has a similar prevalence in the EU. TED often occurs in people living with Graves' disease and hyperthyroidism and is caused by dysfunction in the IGF-1R signaling pathway which results in fibrous tissue growth behind the eyes. This leads to several negative symptoms that may have long-term, irreversible damage as the tissue growth pushes the eyes forward or causes the eyes and eyelids to become red and swollen. As the disease progresses it can lead to pain, eye bulging (proptosis), and double vision (diplopia), thus dramatically impacting a patient's quality of life. TED predominantly affects women, and most frequently affects people with hyperthyroidism due to Graves' disease. Current standard of care typically involves either invasive orbital surgery or a lengthy series of infusions with potential adverse events like loss of hearing, hyperglycemia or menstrual cycle changes. About Sling Therapeutics Sling Therapeutics, Inc., is a late-stage biopharmaceutical company focused on the development of an oral small molecule for the treatment of thyroid eye disease (TED). The company's lead product candidate, linsitinib, works by inhibiting the validated IGF-1R target. It recently completed a Phase 2b/3 clinical trial for the treatment of TED and is on target for initiating its confirmatory Phase 3 trial in 2025. Based on extensive preclinical and clinical data from more than 900 patients, linsitinib offers the potential of a convenient oral small molecule that could significantly reduce the treatment burden for people living with TED while improving and simplifying patient care by physicians and hospitals. For more information, please visit or follow us on LinkedIn or X (formerly known as Twitter). Investor and Media Contact: Argot Partners (212) 600-1902 [email protected] SOURCE Sling Therapeutics, Inc. WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

Clinical ResultPhase 3

14 Jan 2025

·endpts.com

Regeneron, Illumina invest in Truveta; Inhibrx Bio’s $150M loan

Plus, news about Bioptimus, RhyGaze, Grifols, subcutaneous Leqembi and Sling Therapeutics: Regeneron pours $119.5M into Truveta Series C: Regeneron will also work with the medical data research company to launch a genome project that aims to sequence ten million patient volunteers. Illumina is also investing $20 million into the Series C. – Ayisha Sharma Inhibrx Bio inks loan facility for up to $150M: The funding should give the San Diego-based biotech “strategic flexibility” beyond anticipated data readouts later this year for two of its programs — INBRX-109 and INBRX-106. Inhibrx has so far received an initial $100 million from the five-year term agreement with Oxford Finance. – Ayisha Sharma Bioptimus gets $41M in new financing: The raise brings the company’s total amount to $76 million after it debuted last February with a $35 million seed round. Bioptimus will use the money to “enhance its multi-modal AI platform,” it said in a press release, which may include the ability to sign partnerships with biopharma companies. — Max Gelman Ophthalmic biotech secures $86M in Series A: Basel-based RhyGaze plans to use the proceeds to advance its lead gene therapy candidate designed to restore vision in diseases that cause blindness. Google Ventures led the fundraise, with support from the likes of Novartis Venture Fund and ARCH Venture Partners. – Ayisha Sharma Grifols gets $21M grant for Parkinson’s research: The company received the grant from the Michael J. Fox Foundation for Parkinson’s Research. It will fund a pilot study to analyze plasma samples from Parkinson’s patients for up to 10 years, which the company hopes will help bring about better diagnostic tools and therapeutics for patients. — Max Gelman FDA accepts BLA for subcutaneous Leqembi: Eisai and Biogen are seeking approval for the amyloid-targeting antibody as a weekly maintenance therapy in early Alzheimer’s disease. The agency will issue a decision by Aug. 31. — Elizabeth Cairns Sling’s thyroid eye disease pill hits: The IGF-1R inhibitor linsitinib reduced proptosis (eye bulging) in 52% of Phase 2b/3 trial subjects given the higher 150 mg twice-daily dose for six months. Sling did not give details for the 75 mg dose, but said the drug was well-tolerated. A pivotal Phase 3 trial is expected to start this year. — Elizabeth Cairns

Phase 3Gene Therapy

100 Deals associated with Linsitinib

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D09925	Linsitinib	-	DB06075

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Graves Ophthalmopathy	Phase 3	United States	Sling Therapeutics, Inc.	01 Jul 2022
Graves Ophthalmopathy	Phase 3	Canada	Sling Therapeutics, Inc.	01 Jul 2022
Graves Ophthalmopathy	Phase 3	Italy	Sling Therapeutics, Inc.	01 Jul 2022
Graves Ophthalmopathy	Phase 3	Spain	Sling Therapeutics, Inc.	01 Jul 2022
Graves Ophthalmopathy	Phase 3	United Kingdom	Sling Therapeutics, Inc.	01 Jul 2022
Hashimoto Disease	Phase 3	United States	Sling Therapeutics, Inc.	01 Jul 2022
Hashimoto Disease	Phase 3	Canada	Sling Therapeutics, Inc.	01 Jul 2022
Hashimoto Disease	Phase 3	Italy	Sling Therapeutics, Inc.	01 Jul 2022
Hashimoto Disease	Phase 3	Spain	Sling Therapeutics, Inc.	01 Jul 2022
Hashimoto Disease	Phase 3	United Kingdom	Sling Therapeutics, Inc.	01 Jul 2022

Clinical Result

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Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT01560260 (SARC, Pubmed \| Clin Cancer Res) Manual	Phase 2	Gastrointestinal Stromal Tumors	20	Linsitinib	gweprzxmxa(koqmjmotih) = imrpzqnppu giktcvdcbi (pzixhisrks ) View more	Positive	15 Apr 2020
NCT02546544 (LINES, CTgov)	Phase 2	Recurrent Ewing Sarcoma \| Refractory Ewing Sarcoma	16	Linsitinib	csgpkqbxcg(suwsoefnkx) = bqeldkmfnf agyprxuxem (ydobyrccbt, cieknvnubm - tnkiwermes) View more	-	03 Jun 2019
NCT01672736 (CTgov)	Phase 1/2	Relapse multiple myeloma	19	Dexamethasone+Velcade+ASP7487	nhfdusuioq = etlpynycgc ojaxyxxnwe (dahpyqauss, yhbylqydmf - vneqnxwgur) View more	-	13 Sep 2018
NCT01186861 (Pubmed \| Med J Aust) Manual	Phase 2	Non-Small Cell Lung Cancer Maintenance	205	erlotinib+linsitinib	mosiumhwnu(bhhdxrioox): P-Value = 0.601 View more	Negative	05 Sep 2017
				erlotinib+Placebo
NCT01560260 (SARC, CTgov)	Phase 2	Paraganglioma \| Chondrosarcoma \| Gastrointestinal Stromal Tumors ... View more	20	Pharmacological Study+Linsitinib	sulmxyphjy = yclfkcctba siejzjznva (efjrhjrtqd, btdfzxlkdv - bwoqbpzxgh) View more	-	19 Jan 2017
NCT01221077 (Pubmed \| Clin Lung Cancer) Manual	Phase 2	Non-Small Cell Lung Cancer	88	erlotinib+Linsitinib	timvxotecn(ccwglcdvkm) = dzuvaiujnr txfdbfezsi (jkmxzjlkvt ) View more	Negative	01 Jan 2017
				erlotinib+Placebo	timvxotecn(ccwglcdvkm) = utvarapqpa txfdbfezsi (jkmxzjlkvt ) View more
NCT01533181 (Pubmed \| Oncologist) Manual	Phase 2	Recurrent Lung Small Cell Carcinoma	44	Topotecan Hydrochloride	rzmmjsnwmi(myeckilkta) = eusvtxtmui gggorvywun (cchrssoopx, 1.5 - 3.6) View more	Negative	01 Oct 2016
				Linsitinib	rzmmjsnwmi(myeckilkta) = ucsgbpoybn gggorvywun (cchrssoopx, 1.1 - 1.4) View more
NCT01533181 (CTgov)	Phase 2	Recurrent Lung Small Cell Carcinoma	44	Topotecan (Arm A: Topotecan)	gafstbfybn(ocshnaflxp) = lpjzwlvzob kjnvnfgmog (utqclajgqg, hlngvtfihi - ssclviuypq) View more	-	14 Jan 2016
				OS-906 (Arm B: OS-906)	gafstbfybn(ocshnaflxp) = qftlgcqbac kjnvnfgmog (utqclajgqg, forgogtsil - bhuqektznp) View more
NCT00924989 (Pubmed \| Lancet Oncol) Manual	Phase 3	Adrenocortical Carcinoma	139	Linsitinib	bshysvvqec(grympcnvfn) = egufcrhxkg tpbopzckzn (hkfudgokdr )	Negative	01 Apr 2015
				Placebo	bshysvvqec(grympcnvfn) = jfjkjntups tpbopzckzn (hkfudgokdr ) View more
NCT01533246 (CTgov)	Phase 2	Recurrent Prostate Carcinoma \| Metastatic castration-resistant prostate cancer \| Adenocarcinoma of prostate	17	laboratory biomarker analysis+linsitinib	jfzhvpkgqc = xxhvvbgkyo ivuugxhmon (zluhwwrmbx, xwigerzzmw - ycknqrfqgx) View more	-	13 Mar 2015

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