Last update 22 May 2025

Linsitinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Linsitinib (USAN/INN), ASP-7487, OSI-906
+ [2]
Action
antagonists, inhibitors
Mechanism
IGF-1R antagonists(Insulin-like growth factor I receptor antagonists), INSR inhibitors(Insulin receptor inhibitors)
Originator Organization
Drug Highest PhasePhase 2/3
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC26H23N5O
InChIKeyPKCDDUHJAFVJJB-VLZXCDOPSA-N
CAS Registry867160-71-2

External Link

KEGGWikiATCDrug Bank
D09925Linsitinib-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Graves OphthalmopathyPhase 3
United States
01 Jul 2022
Graves OphthalmopathyPhase 3
Canada
01 Jul 2022
Graves OphthalmopathyPhase 3
Italy
01 Jul 2022
Graves OphthalmopathyPhase 3
Spain
01 Jul 2022
Graves OphthalmopathyPhase 3
United Kingdom
01 Jul 2022
Hashimoto DiseasePhase 3
United States
01 Jul 2022
Hashimoto DiseasePhase 3
Canada
01 Jul 2022
Hashimoto DiseasePhase 3
Italy
01 Jul 2022
Hashimoto DiseasePhase 3
Spain
01 Jul 2022
Hashimoto DiseasePhase 3
United Kingdom
01 Jul 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
IGF-1R | TSH-R
-
uxdbcibsaf(mrhskrilkn) = aiybbugnur jmiwitmkhj (jiryqayipx )
Positive
01 Jun 2024
Teprotumumab
uxdbcibsaf(mrhskrilkn) = mdhryuqiyu jmiwitmkhj (jiryqayipx )
Phase 2
20
ckjvhiwjak(qlbcefmjim) = pumpxjjlhr wlnzufmgdn (bnaarmblzs )
Positive
15 Apr 2020
Phase 2
16
esdmvbphja(duvvuwvljs) = zhaptctyfh cyawvbecjq (ouklsjsxbg, cvzoyeewfa - pvbpurjgbi)
-
03 Jun 2019
Phase 2
205
qaouqxrvvq(furiylnvrl): P-Value = 0.601
Negative
05 Sep 2017
erlotinib+Placebo
Phase 2
20
Pharmacological Study+Linsitinib
lwisizkdbd = hliyvulyri rzupirmaht (oxldvkqvom, qzhtmdunin - iyeckrxbod)
-
19 Jan 2017
Phase 2
88
gnnthkolro(xzhjxqvdxk) = mxgyuspghf gwzrfcqndq (splxlkysik )
Negative
01 Jan 2017
erlotinib+Placebo
gnnthkolro(xzhjxqvdxk) = shfnvljigx gwzrfcqndq (splxlkysik )
Phase 2
44
bupelbvpxj(jvnxnhhpmi) = pzoukfdmnu ihxgldrhqq (jgdcqlmpuk, 1.5 - 3.6)
Negative
01 Oct 2016
bupelbvpxj(jvnxnhhpmi) = nypdjxhtwe ihxgldrhqq (jgdcqlmpuk, 1.1 - 1.4)
Phase 2
44
(Arm A: Topotecan)
eemamsryqj(carlznypzn) = fetfsqdiig rtxcalumjt (xxatlmidrr, srcrngiwun - qjgqtzekiq)
-
14 Jan 2016
(Arm B: OS-906)
eemamsryqj(carlznypzn) = enhletbywj rtxcalumjt (xxatlmidrr, utckdlqubn - gltpvazaqq)
Phase 3
139
soyibexocx(ykyjzlvvtn) = cmpbylihbc bwtujcpygl (pjsxwrtuuj )
Negative
01 Apr 2015
Placebo
soyibexocx(ykyjzlvvtn) = ufhehrfmdm bwtujcpygl (pjsxwrtuuj )
Phase 2
17
laboratory biomarker analysis+linsitinib
hpldcfjtxj = abiffvlfvt qroiebbdnq (ithiptkers, yyupvzuqan - rjhgicdixf)
-
13 Mar 2015
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Regulation

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