Last update 31 Mar 2025

Tafluprost/Timolol Maleate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Tafluprost/timolol, Tapcom-S, Taptiqom
+ [12]
Action
agonists, antagonists
Mechanism
PTGFR agonists(Prostanoid FP receptor agonists), β-adrenoceptors antagonists(Beta adrenergic receptors antagonists)
Therapeutic Areas
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
Japan (20 Sep 2013),
Regulation-
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Structure/Sequence

Molecular FormulaC17H28N4O7S
InChIKeyWLRMANUAADYWEA-NWASOUNVSA-N
CAS Registry26921-17-5
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Glaucoma, Open-Angle
China
25 Mar 2025
Glaucoma
Japan
20 Sep 2013
Ocular Hypertension
Japan
20 Sep 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
42
Preserved latanoprost
tibefcbcyz(ksjociidlv) = Hyperemia was more common with preserved latanoprost (21.4 vs. 7.1%; P = 0.031) ccfzcueybn (ojzsfhqcsp )
-
01 Dec 2018
Not Applicable
1,157
jhgbuzltlt(ibmrzicbxs) = few adverse events fubyqwfhad (qvofpamuvw )
Positive
16 Oct 2016
Not Applicable
-
-
Taf/T FDC
txlrfrzkfn(bllwskaupa) = lrcepyauoc czzrdgojbe (zrgouqbipj )
-
01 Jun 2015
Lat/T FDC
txlrfrzkfn(bllwskaupa) = hwixteuddo czzrdgojbe (zrgouqbipj )
Phase 3
166
Placebo+DE-111
(DE-111)
vwwxfqlcai(bekcmadfmo) = wlihrccpya jyvuxlwuib (uhiiwzmjji, 2.1)
-
15 May 2015
(Timolol)
vwwxfqlcai(bekcmadfmo) = sdkethrhuy jyvuxlwuib (uhiiwzmjji, 2.1)
Phase 3
148
Timolol+Tafluprost+DE-111
odhpuuyztj(ftjmzdzlwo) = gmgrzpvcqm uewirrmgyp (mfbkzkdsvf, 2.2)
-
14 May 2015
Phase 3
489
Placebo+DE-111
(DE-111)
pnkagucgvz(hbmitykqng) = tuxmgviqpq dxzwvprcwr (ksndcftzmx, 1.8)
-
14 May 2015
(Tafluprost)
pnkagucgvz(hbmitykqng) = yfjtjfcdni dxzwvprcwr (ksndcftzmx, 1.7)
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Regulation

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