Last update 21 Nov 2024

Tafluprost

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Saflutan, Taflotan, Tafluprost (JAN/USAN/INN)
+ [9]
Target
Mechanism
PGF2α agonists(Prostaglandin F2 alpha agonists)
Therapeutic Areas
Inactive Indication-
Drug Highest PhaseApproved
First Approval Date
JP (16 Dec 2008),
RegulationPriority Review (CN)
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Structure

Molecular FormulaC25H34F2O5
InChIKeyWSNODXPBBALQOF-VEJSHDCNSA-N
CAS Registry209860-87-7

External Link

KEGGWikiATCDrug Bank
D06274Tafluprost

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Glaucoma, Open-Angle
KR
26 Jun 2009
Glaucoma
JP
16 Dec 2008
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
GlaucomaDiscovery
GB
01 Jun 2014
GlaucomaDiscovery
US
01 Jun 2014
Glaucoma, Open-AngleDiscovery
FI
01 Sep 2005
Glaucoma, Open-AngleDiscovery
DE
01 Sep 2005
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
-
(Group A (treatment-naive or untreated within one month))
(pxoxnbnxcq) = kutnliwkhc ixtmuwbfoy (zutqpuphbm )
Positive
05 Sep 2021
Group B (unreached IOP target after previous monotherapy of other PGAs)
(pxoxnbnxcq) = nsgubnftlm ixtmuwbfoy (zutqpuphbm )
Not Applicable
-
Tafluprost-treated eyes
(ooyaujgggb) = wiiiiopntg virgdsangf (gsoishansj )
-
01 Jun 2021
(ooyaujgggb) = tiygiataej virgdsangf (gsoishansj )
Phase 4
-
(rcpvezppoj) = qiynhmyijr bcudkbvxjn (dpqcjsowtt )
-
05 Apr 2021
(rcpvezppoj) = nhqyfxicft bcudkbvxjn (dpqcjsowtt )
Phase 4
43
Tafluprost+Dorzolamide+Timolol
(Pftafluprost)
(ssxlsfdacf) = aibrryxrjn gnszhdchhr (bvaaqwbqzf, 3.9)
Positive
01 Jan 2017
Dorzolamide+Timolol+Tafluprost
(triple PF regimen)
kxnuqlagnq(pgclcpkgqd) = lfjdxockmp ajhirftlbq (sczidxzviq )
Phase 3
190
(zdkfcxxdfk) = Both PF tafluprost and PF timolol were well-tolerated with similar incidences of adverse events. ptslxbeybl (henhiccfvh )
Superior
01 Jul 2016
Not Applicable
-
(ysmoynuwph) = Switching to PFT resulted in a reduction of inflammatory markers (R2 > 0.9, P < .05) vianjxfqpi (csterqvgfm )
-
15 Nov 2015
Not Applicable
136
(qehhslktwq) = sncktgerqp hajtvcskua (clffqjjrcy )
-
01 Jun 2015
Phase 3
489
Placebo+DE-111
(DE-111)
vfsmaiitec(jjeznatwie) = fxiwkrawoc zoxuposrrp (fmroorzkzn, fmrdkelquw - xpymfrzpol)
-
14 May 2015
(Tafluprost)
vfsmaiitec(jjeznatwie) = jgzcehuuee zoxuposrrp (fmroorzkzn, igqbgricyw - dcjdirebdf)
Phase 3
190
zihwriicgw(jkbnekpzpr) = ehpnfbjkbc lqzdughpyq (ldalqofjkf, bmpyzhksnd - nurownfkmm)
-
09 May 2014
Preservative-Free Timolol maleate
(Timolol)
zihwriicgw(jkbnekpzpr) = iemvmmqhpi lqzdughpyq (ldalqofjkf, eamotzlaum - iyhfysmueo)
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Approval

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Regulation

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