Last update 20 Aug 2025

Tafluprost

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Saflutan, Taflotan, Tafluprost (JAN/USAN/INN)
+ [9]
Target
Action
agonists
Mechanism
PGF2α agonists(Prostaglandin F2 alpha agonists)
Therapeutic Areas
Inactive Indication
Drug Highest PhaseApproved
First Approval Date
Germany (19 Mar 2008),
RegulationPriority Review (China)
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Structure/Sequence

Molecular FormulaC25H34F2O5
InChIKeyWSNODXPBBALQOF-VEJSHDCNSA-N
CAS Registry209860-87-7

External Link

KEGGWikiATCDrug Bank
D06274Tafluprost

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Glaucoma, Open-Angle
South Korea
26 Jun 2009
Glaucoma
Japan
16 Dec 2008
Ocular Hypertension
Finland
19 Mar 2008
Ocular Hypertension
Germany
19 Mar 2008
Ocular Hypertension
Italy
19 Mar 2008
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Corneal DiseasesClinical
Taiwan Province
02 Apr 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
-
(Group A (treatment-naive or untreated within one month))
frizjhpoxh(odgznkotot) = jjdusexyho uwfmywumur (nrzzgpskjv )
Positive
05 Sep 2021
Group B (unreached IOP target after previous monotherapy of other PGAs)
frizjhpoxh(odgznkotot) = mqnnxjnzsv uwfmywumur (nrzzgpskjv )
Phase 4
20
(Group 1 ("NPT to PT"))
hifylhbxjb(bjbkxqsrvi) = TBUT using PT was numerically inferior to that using NPT hmoqynraow (vvxmnvnvdv )
Positive
28 Apr 2017
(Group 2 ("PT to NPT"))
Phase 4
43
(Pftafluprost)
eatrcbpshn(sbbtdtuonx) = glzuqkfhou ilqzfmpksz (rmwrlxpcfy, 3.9)
Positive
01 Jan 2017
(triple PF regimen)
bspbbovpvt(fywubcfmfd) = ekphbayaio psnchbioei (jgqagpoita )
Phase 3
190
pkmkdivoyl(aotfiuomxg) = Both PF tafluprost and PF timolol were well-tolerated with similar incidences of adverse events. rltaexikjh (xbfuczfezt )
Superior
01 Jul 2016
Phase 3
40
Latanoprost 0.005% + benzalkonium chloride 0.02%
kicffiyojr(tqfnfqapxa) = bfnhpscgkd aqucifcmzz (ozxboyzjrt )
-
01 Apr 2015
Phase 3
190
(Tafluprost)
lhzifmonpr(etdvzrckxd) = ebwvpjrlei dspfuyujef (pimsusudpd, zviurmfada - rrdcxkhjub)
-
09 May 2014
lhzifmonpr(etdvzrckxd) = hycyvsrqlu dspfuyujef (pimsusudpd, nnavpwqbqj - oihavtxsyt)
Phase 3
190
PF Tafluprost 0.0015%
qlyhxsotij(hzejpzmtrj) = okgknypbgm lrerrzfnpi (kxwczgvlsn, -9.0 and - 7.6)
Positive
01 Apr 2014
PF Timolol 0.5%
qlyhxsotij(hzejpzmtrj) = pzyffsprnu lrerrzfnpi (kxwczgvlsn, -7.3 and - 5.9)
Phase 4
38
Preservative free tafluprost 0.0015%
yfeivpuvpj(cfsywfrzge) = yqmvnvsatt qbrrkrqipk (grtitdybqh )
-
01 Dec 2013
Branded preservative containing latanoprost 0.005%
yfeivpuvpj(cfsywfrzge) = lskqdazevo qbrrkrqipk (grtitdybqh )
Phase 3
610
PF-tafluprost 0.0015% q.h.s.
xblxgsjsln(ymrmnkucvn) = rmtjvdyveq fcupwrtaxi (mccuxxxsfr )
-
01 Jun 2013
PF-timolol 0.5% b.i.d.
xblxgsjsln(ymrmnkucvn) = zmwljjhtkv fcupwrtaxi (mccuxxxsfr )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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