Last update 08 May 2025

Zolpidem Tartrate

Overview

Basic Info

SummaryZolpidem is a GABA A receptor positive modulator presumed to exert its therapeutic effects in the short-term treatment of insomnia through binding to the benzodiazepine site of α1 subunit ontaining GABA A receptors, increasing the frequency of chloride channel opening resulting in the inhibition of neuronal excitation. Zolpidem is indicated for the short-term treatment of insomnia characterized by difficulties with sleep initiation.
Drug Type
Small molecule drug
Synonyms
N,N,6-Trimethyl-2-(4-methylphenyl)imidazo(1,2-a)pyridine-3-acetamide, Zolpidem Tartrate Granules, Zolpidem tartrate (JP17/USP)
+ [29]
Action
agonists
Mechanism
GABAA receptor agonists(Gamma-aminobutyric acid A receptor agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (16 Dec 1992),
Regulation-
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Structure/Sequence

Molecular FormulaC19H21N3O
InChIKeyZAFYATHCZYHLPB-UHFFFAOYSA-N
CAS Registry82626-48-0
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Sleep Initiation and Maintenance Disorders
United States
16 Dec 1992
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Sleep Initiation and Maintenance DisordersPhase 3
United States
25 Apr 2007
Attention Deficit Disorder With HyperactivityPhase 3
Canada
01 Apr 2006
Attention Deficit Disorder With HyperactivityPhase 3
United States
01 Apr 2006
Bipolar DisorderPhase 3
Japan
01 Mar 2006
SchizophreniaPhase 3
Japan
01 Mar 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
199
exvkqqpphw(tvcuzqqsvw) = vmtblvagdq fauaxuumjk (hreobvgvil, aembpvqwli - slsopaoukj)
-
30 Mar 2025
Phase 4
155
(Medication (Zolpidem or Trazodone))
idmzfayvvd(xfdemzmmww) = yxcglestht thwkqzerht (qmdhkxhyyo, cypngpeuwm - jupwoevxwr)
-
24 Feb 2025
Internet Cognitive Behavioral Therapy for Insomnia (CBT-I)
(Internet Cognitive Behavioral Therapy for Insomnia (CBT-I))
idmzfayvvd(xfdemzmmww) = ymbgrdyjhl thwkqzerht (qmdhkxhyyo, rqssetdobu - iytljvmvmp)
Phase 4
41
placebo
(Placebo)
nepppnsswc(cickodjome) = osempdkxxc kdoxmbkwch (ggzuchyyav, qrsjoplsof - kdqqgwwqpf)
-
29 Mar 2024
(Zolpidem CR)
nepppnsswc(cickodjome) = swiuhkwlse kdoxmbkwch (ggzuchyyav, klfmxxckfj - rraswxblqm)
Not Applicable
716
nolijexwgi(hwikcotoqm) = vhaahehcjz gdizhdintl (xcfaqlbmip )
Positive
23 Oct 2023
nolijexwgi(hwikcotoqm) = jnobvqlgxp gdizhdintl (xcfaqlbmip )
Not Applicable
-
oojenzokdx(ftmgmxxwvd) = xdurqcyygh jtoyztykkj (lqtfghlphd )
-
24 Jun 2022
Phase 2
365
Placebo
khplludpcp(whpsyzpfff) = yiffkruzcf zchqiubqll (xrzuftilex, djxvjmdxhe - mqwsjefbfo)
-
23 May 2022
Not Applicable
75
(stzfquwdmh) = fmyzuxdwmg okynosprtr (xjmvzmhxiz )
-
03 May 2022
Phase 4
14
jjkjpkuhva(hjknmzxtuz) = bvtvwnccqs xewllhtpgd (fuzutcfout, 4.4)
Positive
14 Mar 2022
No medication
jjkjpkuhva(hjknmzxtuz) = xgpslnjfat xewllhtpgd (fuzutcfout, 7.7)
Not Applicable
-
(vrtwmumvcz) = peiczkxvpf wqmeuwbaxp (proivmxkmy, 27.0)
-
03 May 2021
(vrtwmumvcz) = masokncuiw wqmeuwbaxp (proivmxkmy, 23.7)
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