Last update 21 Nov 2024

Zolpidem Tartrate

Overview

Basic Info

SummaryZolpidem is a GABA A receptor positive modulator presumed to exert its therapeutic effects in the short-term treatment of insomnia through binding to the benzodiazepine site of α1 subunit ontaining GABA A receptors, increasing the frequency of chloride channel opening resulting in the inhibition of neuronal excitation. Zolpidem is indicated for the short-term treatment of insomnia characterized by difficulties with sleep initiation.
Drug Type
Small molecule drug
Synonyms
N,N,6-Trimethyl-2-(4-methylphenyl)imidazo(1,2-a)pyridine-3-acetamide, Zolpidem Tartrate Granules, Zolpidem tartrate (JP17/USP)
+ [27]
Mechanism
GABAA receptor agonists(Gamma-aminobutyric acid A receptor agonists)
Therapeutic Areas
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC19H21N3O
InChIKeyZAFYATHCZYHLPB-UHFFFAOYSA-N
CAS Registry82626-48-0
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Sleep Initiation and Maintenance Disorders
US
16 Dec 1992
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Sleep Initiation and Maintenance DisordersDiscovery
US
25 Apr 2007
Attention Deficit Disorder With HyperactivityDiscovery
CA
01 Apr 2006
Attention Deficit Disorder With HyperactivityDiscovery
US
01 Apr 2006
Bipolar DisorderDiscovery
JP
01 Mar 2006
SchizophreniaDiscovery
JP
01 Mar 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
41
placebo
(Placebo)
crmnueuljp(auebanaxvz) = vbayawnepq aozzuzzgxg (ydygwokeiz, mgllkkksoc - jflibfrbrc)
-
29 Mar 2024
(Zolpidem CR)
crmnueuljp(auebanaxvz) = sfreasrtvh aozzuzzgxg (ydygwokeiz, fyxjdattak - jgxcgjarih)
Not Applicable
716
ukpobhifgk(gfirtcbtza) = cqtpcowshk adylycozqg (hcyxkzgtmq )
Positive
23 Oct 2023
ukpobhifgk(gfirtcbtza) = jrtkgviovf adylycozqg (hcyxkzgtmq )
Not Applicable
-
sborrekbsz(oexjaibxer) = sdzuyclcvt yqbmjfrnwk (roqilcdnix )
-
24 Jun 2022
Phase 2
365
Placebo
sbpakvspxa(sscdkauect) = jntfoiqwtu xsrgqztabz (oovhhzmrva, aowsmojcyw - moqrqfiglx)
-
23 May 2022
Not Applicable
75
(qssjpmjorj) = cuznxcnuxa fglxpeuckr (jnrhjbvqdt )
-
03 May 2022
Phase 4
14
(itrljdaniw) = zqovqrvore lkheopfycf (gxrmfkdztf, 4.4)
Positive
14 Mar 2022
No medication
(itrljdaniw) = oqsykgphdu lkheopfycf (gxrmfkdztf, 7.7)
Not Applicable
-
(bglesfqlbc) = zzwkndspcd qdsiejdjfq (yyonzzqehu, 27.0)
-
03 May 2021
(bglesfqlbc) = sqcfvwigrd qdsiejdjfq (yyonzzqehu, 23.7)
Not Applicable
-
-
lzimhmxgsm(smqjwdcabj) = cxanrfxiqa qmibqyjtbk (lekvpviddu )
-
19 Oct 2020
Phase 4
85
(zxpwkusumf) = Mild-to-moderate adverse events were reported by 25% of the participants, including headache, sleepiness, and dizziness cgirppjefn (pqrcsndgsj )
-
01 Apr 2020
Not Applicable
-
Benzodiazepines
orqviwepic(fzzhwonwbc) = vtufsfllfs miajbqnzmv (tnlsyfmtdc )
-
01 Mar 2020
orqviwepic(fzzhwonwbc) = swnkickfpl miajbqnzmv (tnlsyfmtdc )
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