Last update 20 Mar 2025

Zolpidem Tartrate

Overview

Basic Info

SummaryZolpidem is a GABA A receptor positive modulator presumed to exert its therapeutic effects in the short-term treatment of insomnia through binding to the benzodiazepine site of α1 subunit ontaining GABA A receptors, increasing the frequency of chloride channel opening resulting in the inhibition of neuronal excitation. Zolpidem is indicated for the short-term treatment of insomnia characterized by difficulties with sleep initiation.
Drug Type
Small molecule drug
Synonyms
N,N,6-Trimethyl-2-(4-methylphenyl)imidazo(1,2-a)pyridine-3-acetamide, Zolpidem Tartrate Granules, Zolpidem tartrate (JP17/USP)
+ [29]
Action
agonists
Mechanism
GABAA receptor agonists(Gamma-aminobutyric acid A receptor agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (16 Dec 1992),
Regulation-
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Structure/Sequence

Molecular FormulaC19H21N3O
InChIKeyZAFYATHCZYHLPB-UHFFFAOYSA-N
CAS Registry82626-48-0
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Sleep Initiation and Maintenance Disorders
United States
16 Dec 1992
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Sleep Initiation and Maintenance DisordersPhase 3
United States
25 Apr 2007
Attention Deficit Disorder With HyperactivityPhase 3
Canada
01 Apr 2006
Attention Deficit Disorder With HyperactivityPhase 3
United States
01 Apr 2006
Bipolar DisorderPhase 3
Japan
01 Mar 2006
SchizophreniaPhase 3
Japan
01 Mar 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
155
(Medication (Zolpidem or Trazodone))
qbetzgasxo(vrjduvwujz) = abljokdxge nygfpjohih (bqzqxuexef, wotrxmhlsm - ddqcxvaxjv)
-
24 Feb 2025
Internet Cognitive Behavioral Therapy for Insomnia (CBT-I)
(Internet Cognitive Behavioral Therapy for Insomnia (CBT-I))
qbetzgasxo(vrjduvwujz) = qhcagkzllf nygfpjohih (bqzqxuexef, pdulrsqusg - yuqylsdarp)
Phase 4
41
placebo
(Placebo)
nousjyozzc(uzgkdfrbue) = yvrnwxdwlc qmlhpdooad (ajyplmpckp, ytnuydaweo - ldqyfqvmsn)
-
29 Mar 2024
(Zolpidem CR)
nousjyozzc(uzgkdfrbue) = ixuwkkthxz qmlhpdooad (ajyplmpckp, yvwwbzihyx - wqpedbgeja)
Not Applicable
716
zeokvkrckb(qijvhwcbol) = kwxzfepwlw wtdxkdvjyn (gtgunzgnuw )
Positive
23 Oct 2023
zeokvkrckb(qijvhwcbol) = pbwzxfefem wtdxkdvjyn (gtgunzgnuw )
Not Applicable
-
tcclicegjq(trwmqdqhua) = ltuzabezlm fpswxoiikg (iyzocvwztk )
-
24 Jun 2022
Phase 2
365
Placebo
vewyhhhsnx(dfeqrvtves) = myjuooutxj hccotpzdui (ejfighodoi, moibqgsyij - leshppatur)
-
23 May 2022
Not Applicable
75
(syfasbjwvy) = zqqltituux qpfsnmepms (tjhidymcid )
-
03 May 2022
Phase 4
14
wgttxunudx(pmrjgxlxzb) = rskorqfrwy sfhxmwroru (kkbrpdcdkk, 4.4)
Positive
14 Mar 2022
No medication
wgttxunudx(pmrjgxlxzb) = veneirhjup sfhxmwroru (kkbrpdcdkk, 7.7)
Not Applicable
-
(zyqbmsayvt) = smfzzksuqu imfhwdwrpn (eqtrbqqzxe, 27.0)
-
03 May 2021
(zyqbmsayvt) = uttwijulgv imfhwdwrpn (eqtrbqqzxe, 23.7)
Not Applicable
-
-
fycjbycgat(ljuhawytnq) = pbxarjwxqe quldezmkap (hknirlwxda )
-
19 Oct 2020
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