Drug Type Small molecule drug |
Synonyms Pemrametostat, 3326595, EPZ-015938 + [1] |
Target |
Mechanism PRMT5 inhibitors(Protein arginine methyltransferase 5 inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhasePhase 2 |
First Approval Date- |
Regulation- |
Molecular FormulaC24H32N6O3 |
InChIKeyJLCCNYVTIWRPIZ-NRFANRHFSA-N |
CAS Registry1616392-22-3 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Early Stage Breast Carcinoma | Phase 2 | CA | 08 Jun 2021 | |
Solid tumor | Phase 2 | US | - | 14 Apr 2021 |
Non-Hodgkin Lymphoma | Phase 2 | US | - | 12 Apr 2021 |
Neoplasms | Phase 2 | US | 16 Oct 2018 | |
Neoplasms | Phase 2 | CA | 16 Oct 2018 | |
Acute Myeloid Leukemia | Phase 2 | US | 16 Oct 2018 | |
Acute Myeloid Leukemia | Phase 2 | CA | 16 Oct 2018 | |
Myelodysplastic Syndromes | Phase 2 | US | 16 Oct 2018 | |
Myelodysplastic Syndromes | Phase 2 | CA | 16 Oct 2018 |
Phase 1 | 218 | (TNBC) | ebdukfbtjw(xluhbtxara) = ufzzmqdgbt dwpywlxozb (qpicvjwfrl ) | Positive | 12 Sep 2022 | ||
(mTCC) | ebdukfbtjw(xluhbtxara) = zsqwigbbkh dwpywlxozb (qpicvjwfrl ) | ||||||
Phase 1 | 54 | czqmvrqhfp(smlrrzqkea) = anemia (n = 8 [15%]), thrombocytopenia, neutropenia, and fatigue (each n = 4 [7%]) vuzydexxdk (nlwpnyhosq ) View more | Positive | 29 Sep 2019 |