Last update 16 May 2025

GSK-3326595

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Pemrametostat, 3326595, EPZ-015938
+ [2]
Target
Action
inhibitors
Mechanism
PRMT5 inhibitors(Protein arginine methyltransferase 5 inhibitors)
Inactive Indication
Originator Organization
Inactive Organization-
License Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC24H32N6O3
InChIKeyJLCCNYVTIWRPIZ-NRFANRHFSA-N
CAS Registry1616392-22-3

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Early Stage Breast CarcinomaPhase 2
Canada
08 Jun 2021
Non-Hodgkin LymphomaPhase 2
United States
-12 Apr 2021
Acute Myeloid LeukemiaPhase 2
United States
16 Oct 2018
Acute Myeloid LeukemiaPhase 2
Canada
16 Oct 2018
Myelodysplastic SyndromesPhase 2
United States
16 Oct 2018
Myelodysplastic SyndromesPhase 2
Canada
16 Oct 2018
AstrocytomaPhase 1
United States
30 Aug 2016
AstrocytomaPhase 1
Canada
30 Aug 2016
AstrocytomaPhase 1
France
30 Aug 2016
AstrocytomaPhase 1
Netherlands
30 Aug 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
Myeloid Tumor
U2AF1 | SRSF2 Mutation
30
GSK3326595 400 mg
zteyfmqowk(dtcmeldqvi) = opplwhonll lwmwerteuy (shpllflgze )
Met
Negative
01 Jan 2024
Phase 1
218
mpstmbrmgt(wysrfxglxa) = zuawsxxpat hkdkgfbuhn (baekxxwzkj )
Positive
12 Sep 2022
mpstmbrmgt(wysrfxglxa) = bwvtyoigrz hkdkgfbuhn (baekxxwzkj )
Phase 1
54
rbmitmtkxs(cvhnrvlpzs) = anemia (n = 8 [15%]), thrombocytopenia, neutropenia, and fatigue (each n = 4 [7%]) fpemwgiahc (zmzndwnulc )
Positive
29 Sep 2019
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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