Delving into the Latest Updates on Tribendimidine with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

力卓

Target-

Action-

Mechanism-

Therapeutic Areas

Infectious Diseases

Active Indication

AscariasisHookworm Infections

Inactive Indication-

Originator Organization

Shandong Xinhua Pharmaceutical Co., Ltd.

Active Organization

Shandong Xinhua Pharmaceutical Co., Ltd.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

China (30 Apr 2004),

AscariasisHookworm Infections

Regulation-

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Structure/Sequence

Molecular FormulaC28H32N6

InChIKeyXOIOGKHKNQYULW-UHFFFAOYSA-N

CAS Registry115103-15-6

SUMMARYClonorchis sinensis , Opisthorchis viverrini , and Opisthorchis felineus are important liver flukes that cause a considerable public health burden in eastern Asia, southeastern Asia, and eastern Europe, respectively. The life cycles are complex, involving humans, animal reservoirs, and two kinds of intermediate hosts. An interplay of biological, cultural, ecological, economic, and social factors drives transmission. Chronic infections are associated with liver and biliary complications, most importantly cholangiocarcinoma. With regard to diagnosis, stool microscopy is widely used in epidemiologic surveys and for individual diagnosis. Immunologic techniques are employed for screening purposes, and molecular techniques facilitate species differentiation in reference laboratories. The mainstay of control is preventive chemotherapy with praziquantel, usually combined with behavioral change through information, education and communication, and environmental control. Tribendimidine, a drug registered in the People’s Republic of China for soil-transmitted helminth infections, shows potential against both C. sinensis and O. viverrini and, hence, warrants further clinical development. Novel control approaches include fish vaccine and biological control. Considerable advances have been made using multi-omics which may trigger the development of new interventions. Pressing research needs include mapping the current distribution, disentangling the transmission, accurately estimating the disease burden, and developing new diagnostic and treatment tools, which would aid to optimize control and elimination measures.

01 Dec 2023·International Journal for Parasitology: Drugs and Drug Resistance

Trichuris muris egg-hatching assay for anthelminthic drug discovery and characterization

Article

Author: Keiser, Jennifer ; Schärer, Anastasia ; Biendl, Stefan

Trichuriasis is a neglected tropical disease widely distributed among tropical and sub-tropical areas and associated with poverty and lack of access to safe drinking water, sanitation and hygiene. Existing drugs have limited efficacy and face a constant risk of developing resistance, necessitating the search for alternative treatments. However, drug discovery efforts are sparse and little research has been performed on anthelminthic effects on embryonated eggs, the infectious life stage of Trichuris spp. We examined bacterial species dependent egg hatching of the murine model parasite Trichuris muris and identified Escherichia coli, Pseudomonas aeruginosa and Enterobacter hormaechei effective as hatching inducers, resulting in hatching yields of 50-70%. Streptococcus salivarius, reported to be associated with reduced drug efficacy of ivermectin-albendazole coadministration in Trichuris trichiura infected patients, did not promote egg hatching in vitro. We optimized hatching conditions using E. coli grown in luria broth or brain-heart infusion media to reach consistently high hatching yields to provide a sensitive, robust and simple egg-hatching assay. Oxantel pamoate demonstrated the strongest potency in preventing hatching, with an EC₅₀ value of 2-4 μM after 24 h, while pyrantel pamoate, levamisole and tribendimidine exhibited only moderate to weak inhibitory effects. Conversely, all tested benzimidazoles and macrolide anthelminthics as well as emodepside failed to prevent hatching (EC₅₀ > 100 μM). Our study demonstrates that egg-hatching assays complement larval and adult stage drug sensitivity assays, to expand knowledge about effects of current anthelminthics on Trichuris spp. Further, the developed T. muris egg-hatching assay provides a simple and cheap screening tool that could potentially lead to the discovery of novel anthelminthic compounds.

04 May 2023·Parasites & vectors

Development of a hookworm egg hatching assay to determine the ovicidal effects of anthelminthics

Article

Author: Easland, Erin ; Keiser, Jennifer ; Biendl, Stefan

Few anthelminthics are currently available, manifesting the urgent need for new treatment options.In vitro profiling of current anthelminthics against larval and adult stage helminths displayed varying effects on closely related worm species and between life stages of the same species.Conversely, limited research has been performed on the egg stage of human hookworms, and the effects of investigational compounds on the egg stage are not routinely assessed.We profiled the development and hatching of Heligmosomoides polygyrus, Ancylostoma duodenale and Necator americanus eggs isolated from rodent faeces in liquid media with various nutrient levels, osmolar concentrations, and acidities in dependence on incubation temperature and light exposure.Incubation conditions were optimized to allow the study of drug effect on immature and embryonated eggs.We analyzed concentration-effect relationships of com. available anthelminthics over 72 h.Rapid embryonation and hatching were observed at room temperature with and without light exposure without nutrient supplementation in a wide range of acidities.Hookworms hatched optimally at room temperature in PBS achieving > 75% hatching over 34 h.Developmental delays were seen when eggs were stored at 4°C with no effect on viability.Similar delays were also seen with increased osmolar concentrations resulting in decreased viability.Benzimidazole anthelminthics effectively reduced the viability and prevented hatching of hookworm eggs, with albendazole and thiabendazole eliciting particularly potent effects at EC50 values below 1μM.Macrolide anthelminthics as well as emodepside, oxantel pamoate, and pyrantel pamoate were inactive while monepantel, levamisole, and tribendimidine displayed varied potencies among the hookworm species.The presented egg-hatching assay will complement ongoing anthelminthic drug discovery and allow a full characterization of drug activity against all life stages.In the development and application of the egg-hatching assay, good accordance was observed between the three hookworm species evaluated.Marketed anthelminthics show differences of drug action compared to larval and adult stages highlighting the importance of profiling drug activity against all life stages.

100 Deals associated with Tribendimidine

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External Link

KEGG	Wiki	ATC	Drug Bank
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R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Ascariasis	China	Shandong Xinhua Pharmaceutical Co., Ltd.	30 Apr 2004
Hookworm Infections	China	Shandong Xinhua Pharmaceutical Co., Ltd.	30 Apr 2004

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ISRCTN81391471 (Pubmed \| Clin Infect Dis)	Phase 2	Hookworm Infections	130	Placebo	(ttcmlgypux) = ygtptexamm zlldllsmoj (eenvxbalvk ) View more	-	16 Aug 2019
				100 mg tribendimidine	(ttcmlgypux) = xfwveijhax zlldllsmoj (eenvxbalvk ) View more
ISRCTN55086560 (Pubmed \| PLoS Negl Trop Dis)	Not Applicable	Clonorchiasis	156	Single-dose tribendimidine 400 mg	iprvynhkpl(qjfolmpjav) = Adverse events caused by tribendimidine were significantly less than praziquantel fijtfxyisx (kpqksptjvy )	-	01 Aug 2014
				75 mg/kg praziquantel
ISRCTN23425032 (Pubmed \| Lancet Infect Dis)	Phase 2	Opisthorchiasis	125	Artesunate	xleufsnzfd(noxbpyxiqw) = zfegpsmvcp winbgyzved (jmpaijakcl )	-	01 Feb 2011
				Mefloquine-artesunate	xleufsnzfd(noxbpyxiqw) = pjjggwmjpp winbgyzved (jmpaijakcl )