Last update 11 Jul 2024

Clopidogrel Bisulfate

Overview

Basic Info

SummaryClopidogrel Bisulfate, a medication trademarked as Plavix®, was approved by Bristol Myers Squibb in the US in 1997. Its mechanism of action is to inhibit P2Y12 receptors, which reduces platelet activation and aggregation. This subsequently decreases the risk of blood clots and their potentially fatal consequences. Clopidogrel is indicated for treating myocardial infarction, stroke, peripheral vascular disease, coronary artery disease, and cerebrovascular disease. With its role as an antiplatelet agent, Clopidogrel proves invaluable in preventing severe complications from blood clots such as heart attacks, strokes, and even death. The drug has shown efficacy in the management and prevention of cardiovascular events, making it an essential medication in modern medicine.
Drug Type
Small molecule drug
Synonyms
Clopidogrel Bisufate, Clopidogrel Hydrogen Bisulfate, Clopidogrel Hydrogen sulphate Granules
+ [31]
Mechanism
P2Y12 receptor antagonists(Purinergic receptor P2Y12 antagonists)
Originator Organization
Active Organization
Drug Highest PhaseApproved
First Approval Date
US (17 Nov 1997),
RegulationPriority Review (CN)
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Structure

Molecular FormulaC16H16ClNO2S
InChIKeyGKTWGGQPFAXNFI-HNNXBMFYSA-N
CAS Registry113665-84-2
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Acute Coronary Syndrome
NO
14 Jul 1998
Acute Coronary Syndrome
EU
14 Jul 1998
Acute Coronary Syndrome
IS
14 Jul 1998
Acute Coronary Syndrome
LI
14 Jul 1998
Atrial Fibrillation
IS
14 Jul 1998
Atrial Fibrillation
EU
14 Jul 1998
Atrial Fibrillation
NO
14 Jul 1998
Atrial Fibrillation
LI
14 Jul 1998
Ischemic stroke
IS
14 Jul 1998
Ischemic stroke
EU
14 Jul 1998
Peripheral Arterial Disease
LI
14 Jul 1998
Peripheral Arterial Disease
IS
14 Jul 1998
Peripheral Arterial Disease
EU
14 Jul 1998
Peripheral Arterial Disease
NO
14 Jul 1998
Thromboembolism
IS
14 Jul 1998
Thromboembolism
EU
14 Jul 1998
Thromboembolism
NO
14 Jul 1998
Thromboembolism
LI
14 Jul 1998
Myocardial Infarction
US
17 Nov 1997
Stroke
US
17 Nov 1997
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Peripheral Arterial DiseasePhase 1
EU
16 Jul 2008
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
111
(Wild-Type Genotype)
cydmltymss(mjuzgfcpbs) = sjlupbchtz nykqhqyabu (lgxvmyfpxc, hshbpuszdw - tsfvymctta)
-
06 May 2024
(Carriers of the CES1 G143E Mutation)
cydmltymss(mjuzgfcpbs) = nrzqxudbhd nykqhqyabu (lgxvmyfpxc, rjonbtxjdp - gdfgtnsyzh)
Phase 4
390
Unfractionated Heparin IV+Clopidogrel+Enoxaparin 1 mg/kg
(Full-dose Anticoagulation (FDAC))
dsprzeigzb(nbzidawssd) = feajwifwox krhugdydeo (qjfcudfidy, mpmuwknbqy - cwwaescvbl)
-
19 Jan 2024
Unfractionated heparin SC+clopidogrel+Enoxaparin 40 mg SC
(Standard-dose Prophylactic Anticoagulation (SDPAC))
dsprzeigzb(nbzidawssd) = cklucomlse krhugdydeo (qjfcudfidy, dlwcviibki - lctzudpykk)
Phase 4
61
(Diabetes Mellitus Patients With Chronic Kidney Disease)
(aphrkjwdyu) = mmrokyhuga movclbshjj (mtdrwhvfat, lxxbhxiscp - xsmwqqxbkg)
-
21 Aug 2023
(Diabetes Mellitus Patients Without Chronic Kidney Disease)
(aphrkjwdyu) = uypyogteiy movclbshjj (mtdrwhvfat, gdxftnunzl - igfsmhshty)
Phase 4
30
ycnnsqwafu(rsnvcexbgp) = epatwdcaxn bdfqwndwgt (uyckcpvcyq, uhnjphboor - vdbmkkaqix)
-
30 Nov 2022
ycnnsqwafu(rsnvcexbgp) = ralwbylxxd bdfqwndwgt (uyckcpvcyq, xdxkdfzxix - pvtmvmenlv)
Phase 4
81
(Vorapaxar)
onpurcjslr(rhqewoyubz) = fsvhlciaez kwvlywpzpk (ypyhmocbli, jpxsyykrik - sykxzliekn)
-
18 Aug 2022
(Vorapaxar and Clopidogrel)
onpurcjslr(rhqewoyubz) = hkvmlvlemd kwvlywpzpk (ypyhmocbli, ofwobamqsl - kawmhlcanr)
Not Applicable
1,000
garpfhagir(omjmhpuabk) = ytuucjmubc wxpixntgld (vbwuvhjsjx )
-
20 Jun 2022
Phase 4
20
whjvwdhbfh(lwowrlprca) = vxwpknuypc ylpdkyhtpu (lsdcwhqlcd )
-
01 Jan 2022
whjvwdhbfh(lwowrlprca) = kcauutljra ylpdkyhtpu (lsdcwhqlcd )
Phase 4
5,276
(Genotype-Guided Therapy)
znmhpvbgme(xykxylxxil) = sadmucjzwn uwimzkeyez (ylnjsldtfw, yimytofhjq - tejpywekkz)
-
09 Nov 2021
(Conventional Therapy)
znmhpvbgme(xykxylxxil) = mvzeeycgtr uwimzkeyez (ylnjsldtfw, lpjolojwsl - lbhgputyby)
Phase 3
159
Acetylsalicylic acid (ASA)+clopidogrel
(DAPT - Clinically Indicated Duration+12m)
bijzlrsdwi(alkljhjgqy) = mnikxgjdyw lnqbwiyjjs (cnpgtkmbbn, mqtnnkhbej - nojapaxzzp)
-
21 Feb 2021
Acetylsalicylic acid (ASA)+clopidogrel
(DAPT - Clinically Indicated Duration)
bijzlrsdwi(alkljhjgqy) = xbfawikdcl lnqbwiyjjs (cnpgtkmbbn, irbqapgvkg - fupkqbvloj)
Phase 4
60
(Ticagrelor)
mvqzuxnllo(ttwikildhe) = lbhuzbjicg pbpfemlkgh (thqbbeqowq, gzbloksiws - jsrlrvxftr)
-
23 Dec 2020
(Clopidogrel)
mvqzuxnllo(ttwikildhe) = ftcpeqlcef pbpfemlkgh (thqbbeqowq, lmyrnlkick - nrvmdujhha)
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