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Last update 30 Oct 2025
Estriol
Last update 30 Oct 2025
Overview
Basic Info
Drug Type Small molecule drug |
Synonyms (16α,17β)-estra-1,3,5(10)-triene-3,16,17-triol, 1,3,5(10)-Estratriene-3,16-alpha,17beta-triol, 16-alpha-Hydroxyestradiol + [18] |
Target |
Action agonists |
Mechanism ERs agonists(Estrogen receptors agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Inactive Organization |
License Organization- |
Drug Highest PhaseApproved |
First Approval Date Japan (18 Nov 1960), |
Regulation- |
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Structure/Sequence
Molecular FormulaC18H24O3 |
InChIKeyPROQIPRRNZUXQM-ZXXIGWHRSA-N |
CAS Registry50-27-1 |
Related
37
Clinical Trials associated with EstriolNCT06873971
Effects of Erbium-Yag Laser in Women With Genitourinary Syndrome of Menopause Undergoing Estrogen Therapy: Randomized, Controlled, Double-Blind Study
ChiCTR2500097448
A randomized controlled trial of platelet-rich plasma therapy for genitourinary syndrome of menopause.
ChiCTR2500098205
Randomized Controlled Trial of Physical Energy-Based Therapy for Genitourinary Syndrome of Menopause in Women
100 Clinical Results associated with Estriol
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100 Translational Medicine associated with Estriol
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100 Patents (Medical) associated with Estriol
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7,844
Literatures (Medical) associated with Estriol31 Dec 2025JOURNAL OF OBSTETRICS AND GYNAECOLOGY
Comparison of vaginal moisturisers with ultra-low-dose oestriol and lactobacillus vaginal tablets in women with POP who used a pessary: a randomised controlled trial
Article
Author: Saraluck, Apisith ; Chinthakanan, Orawee ; Sarit-Apirak, Sirirat ; Wattanayingcharoenchai, Rujira ; Aimjiraku, Komkrit ; Manonai, Jittima
BACKGROUND:
This study aim to compare the proportion of pessary users reporting satisfaction with ultra-low dose oestriol and Lactobacillus vaginal tablets and vaginal moisturiser.
METHODS:
A randomised-controlled trial enrolled patients who were able to take care, insert, and remove a pessary themselves and did not use any local oestrogen or vaginal moisturiser for 3 months at a tertiary centre. Participants were randomised to receive either vaginal moisturisers or ultra-low-dose oestriol and Lactobacillus vaginal tablets for 2 months. A single-blinded evaluator assessed outcomes. The oestriol group received one vaginal tablet daily for 6 days followed by two tablets weekly for 8 weeks. The moisturiser group received one application every 3 days for 8 weeks. The primary outcome was the proportion of patients reporting high satisfaction, defined as 'very much improved' or 'much improved', using the Thai version of the Patient Global Impression of Improvement (PGI-I) scale. Secondary outcomes were subjective and objective outcomes of vaginal health. Sixty patients were randomised, of whom one did not complete treatment.
RESULTS:
The majority of enrolled participants were postmenopausal women with a mean age of 65.54 years, mean BMI of 25.13 kg/m2, and advanced-stage POP. The average duration of pessary use was 12-15 months. Patient satisfaction was not significantly different between the oestriol and moisturiser groups at 4 or 8 weeks (93.10% vs. 96.67%, P = 0.61 and 89.66% vs. 93.33%, P = 0.67, respectively). There were no serious adverse events.
CONCLUSIONS:
Vaginal moisturisers and ultra-low-dose oestriol and Lactobacillus acidophilus vaginal tablets provided high satisfaction in pessary users. Both preparations were comparable in both subjective and objective outcomes.
01 Dec 2025CYTOKINE
Regulation of TREG/TH17 balance by NK cells pretreated with ESTRIOL and bacterial cells in multiple sclerosis
Article
Author: Danchenko, Irina ; Shirshev, Sergei ; Glebezdina, Natalia ; Maslennikova, Irina ; Nekrasova, Irina
We studied the influence of the pregnancy hormone estriol (E3) and bacterial strains on the ability of NK cells to modulate levels of T regulatory (Treg) and IL-17-producing (Th17) lymphocytes from patients with multiple sclerosis (MS) and healthy donors. NK cell phenotype and cytokine production in co-cultures with CD4+ lymphocytes was also investigated after incubation with the hormone and bacterial cells. Treatment of NK cells with these factors stimulated Treg formation and inhibited Th17 development. Within 24 h, NK cell cytotoxicity and production of IL-2 and IFN-γ were inhibited, while IL-10 secretion increased. This was accompanied by a rise in IL-6 and TNF-α. After three days, NK cells showed increased IL-10 and decreased IL-17 expression. Notably, cells from MS patients were more sensitive to this regulatory influence than those from healthy donors.
01 Dec 2025INTERNATIONAL DENTAL JOURNAL
Identification of Drugs Associated With Oral Ulcers Based on Pharmacovigilance
Article
Author: Zhang, Xinyue ; Li, Shiting ; Li, Xueqing ; Huoshen, Wuda
BACKGROUND:
Oral ulcers are common, painful lesions that significantly affect quality of life. Certain medications, especially antimetabolites and mTOR inhibitors, have been implicated in their development. However, drug-induced oral ulcers have not been systematically evaluated using large-scale real-world data.
METHODS:
The study employed a dual-validation strategy combining pharmacovigilance signal mining and multivariate logistic regression analysis. By querying specific 'preferred terms' (PTs), adverse event reports in the FAERS database of the Food and Drugs Adminstration of USA, related to oral ulcers were identified. Signal detection was conducted using four disproportionality analysis methods. For the initially screened candidate drugs, a multivariate logistic regression model was constructed, adjusting for potential confounders such as age, gender, weight, reporter type, reporting country and year, to further validate their independent association with oral ulcer reports (PFDR < .05).
RESULTS:
Reports of oral ulcerations have shown a significant and sustained increase since 2010, peaking in 2020. The multi-method validation framework identified 289 statistically significant drug-oral ulceration association signals. Drugs with the highest signal strength included cyclizine, mycophenolate sodium and aredia. Other drugs with significant signals included lactulose, acetaminophen codeine phosphate, leflunomide, omalizumab, everolimus and atezolizumab. Integrating signal detection results, logistic regression analysis further confirmed that multiple drugs were significantly associated with the risk of oral ulcer reports. Drugs with extremely high odds ratios (ORs) included estriol and docetaxel sagent. Strongly associated drugs also included immunosuppressants, antihistamines, combination analgesics, bisphosphonates, sartans and antibiotics.
CONCLUSION:
This study systematically identified approximately 289 drugs significantly associated with oral ulcer risk, including immunosuppressants, cardiovascular drugs and bronchodilators. Based on pharmacovigilance signal detection and regression analysis, patients on long-term treatment with these drugs should receive enhanced oral monitoring. As this is an observational study, further prospective and experimental research is needed to confirm causality.
2
News (Medical) associated with Estriol
100 Deals associated with Estriol
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R&D Status
Approved
10 top approved records. to view more data
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| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Infertility | China | - | 01 Jan 2000 |
| Vulvovaginal atrophy | United Kingdom | 20 Aug 1982 | |
| Osteoporosis | Japan | 28 Dec 1981 | |
| Female Urogenital Diseases | Japan | 27 Sep 1972 | |
| Menopausal symptoms | Japan | 18 Nov 1960 | |
| Uterine Cervical Erosion | Japan | 18 Nov 1960 | |
| Uterine Cervicitis | Japan | 18 Nov 1960 | |
| Vaginitis | Japan | 18 Nov 1960 |
Developing
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| vaginal mucosa dry | Phase 2 | Czechia | 01 Oct 2016 | |
| vaginal mucosa dry | Phase 2 | Hungary | 01 Oct 2016 | |
| vaginal mucosa dry | Phase 2 | Italy | 01 Oct 2016 | |
| vaginal mucosa dry | Phase 2 | Spain | 01 Oct 2016 | |
| vaginal mucosa dry | Phase 2 | Sweden | 01 Oct 2016 | |
| Atrophic Vaginitis | Phase 2 | Spain | 16 Oct 2015 | |
| Atrophic Vaginitis | Phase 2 | Sweden | 16 Oct 2015 | |
| Early Stage Breast Carcinoma | Phase 2 | Spain | 16 Oct 2015 | |
| Early Stage Breast Carcinoma | Phase 2 | Sweden | 16 Oct 2015 | |
| Multiple Sclerosis | Phase 2 | United States | - |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
View All Results
Phase 3 | 167 | (0.005% Estriol Group) | gmbbtxnbqw(ktaseghvoa) = mbslzttxhb pxsrahbmst (kuulkdogoz, 23.33) View more | - | 11 Dec 2020 | ||
Placebo (Placebo Group) | gmbbtxnbqw(ktaseghvoa) = xdstxraqwt pxsrahbmst (kuulkdogoz, 16.48) View more | ||||||
Phase 2 | 283 | (Estriol 0.005%) | rbikducfpl = bzixjhulit kdnfoztumt (fnuqkqayqe, lfgtdvfbcf - lwacbcqjfd) View more | - | 25 Sep 2019 | ||
(Estriol 0.002%) | rbikducfpl = jllkeviyhx kdnfoztumt (fnuqkqayqe, vdqxbuhzmo - yrpsmhvikt) View more | ||||||
Phase 2 | 61 | (0.005% Estriol Vaginal Gel) | dinwzxazly(yhotpvhqxg) = zgckphwpva bxcghkawuy (iddzoqkpev, yggbqnnrha - qoqhkcfbnf) View more | - | 05 Aug 2019 | ||
Placebo (Placebo Vaginal Gel) | dinwzxazly(yhotpvhqxg) = wssqgswqvv bxcghkawuy (iddzoqkpev, wcaxgmmxqp - pgmxjxtrpv) View more | ||||||
Phase 2 | 123 | (Bevacizumab Spray) | cdfwaiwdlw(vbyuuwqzej) = jaeugoaorp dmaxkfxlax (bgllwyyfgt, hdsesnawdc - iuagscfwxl) View more | - | 19 Oct 2018 | ||
(Estriol Spray) | cdfwaiwdlw(vbyuuwqzej) = opqnaamfqs dmaxkfxlax (bgllwyyfgt, cbfyetnyfp - kksgwnghon) View more | ||||||
Phase 2 | - | 21 | (Study Arm 1) | dgesazvaio(tpbzzksfyq) = kuoknumomr uayjuszeop (wzevlchhmj, 12.5) View more | - | 16 May 2018 | |
(Study Arm 2) | dgesazvaio(tpbzzksfyq) = onecitfkna uayjuszeop (wzevlchhmj, 0) View more | ||||||
Phase 2 | 70 | Estriol vaginal gel | kkpucrvdyb(bhgozowwsg) = One serious adverse event emerged before the patient initiated treatment xheqmwzxpf (mxvpugaeep ) View more | Positive | 15 Feb 2018 | ||
Placebo gel | |||||||
Phase 2 | 158 | vffvtxtlnj(vdpqjtpaql) = webioggoiw uallsumgel (wumqvwaozw, nqpoozshxa - fentblijlt) View more | - | 16 Jun 2016 | |||
Placebo+Copaxone (Placebo Capsules Plus Copaxone Injections) | vffvtxtlnj(vdpqjtpaql) = untqxtxmhr uallsumgel (wumqvwaozw, tfohscxsla - ypptdxonpq) View more | ||||||
Phase 2 | 164 | zttnaunzup(ncwqezidcb) = rtlywrlpfb qtxzetfukm (jcznrsdxgy, 0.17 - 0.37) View more | Positive | 01 Jan 2016 | |||
Placebo | zttnaunzup(ncwqezidcb) = uptjxfvlvm qtxzetfukm (jcznrsdxgy, 0.25 - 0.53) View more | ||||||
Phase 2 | - | Estriol 8 mg per day + Glatiramer Acetate | sjvtxzxxnl(roaqfztnvj) = Trends for improvement at 24 months in the estriol plus glatiramer acetate group, but not in the placebo plus glatiramer acetate group cukywndivv (ikcrkdyymd ) | Positive | 09 Sep 2014 | ||
Placebo + Glatiramer Acetate | |||||||
Phase 3 | 63 | (Estriol) | qocgwgirrh(wfnhxcwmqy) = hffjydupyw zmtcohowwh (jmsqnhqylb, 2.3) View more | - | 28 Mar 2014 | ||
(Estradiol) | qocgwgirrh(wfnhxcwmqy) = nhxurdvfci zmtcohowwh (jmsqnhqylb, 3.3) View more |
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