Last update 15 Jul 2024

Vorolanib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Challenge Meditech 082, CM-082, EYP-1901
+ [3]
Mechanism
PDGFR antagonists(Platelet-derived growth factor receptor antagonists), VEGFR antagonists(Vascular endothelial growth factor receptor antagonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
CN (07 Jun 2023),
RegulationSpecial Review Project (CN)
Login to view First Approval Timeline

Structure

Molecular FormulaC23H26FN5O3
InChIKeyKMIOJWCYOHBUJS-HAKPAVFJSA-N
CAS Registry1013920-15-4

External Link

KEGGWikiATCDrug Bank
---

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Renal Cell Carcinoma
CN
07 Jun 2023
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetic macular oedemaPhase 2-15 Jan 2024
Nonproliferative diabetic retinopathyPhase 2
US
31 Aug 2022
Extensive stage Small Cell Lung CancerPhase 2
US
07 Oct 2020
Glycogen Storage Disease Type IIPhase 2
US
16 Mar 2015
Macular Degeneration, Age-Related, 10Phase 2
US
16 Mar 2015
Wet age-related macular degenerationPhase 2
US
16 Mar 2015
AdenocarcinomaPhase 2
US
03 May 2013
Neuroendocrine tumor of pancreasPhase 2
US
03 May 2013
Age Related Macular DegenerationPhase 2
US
01 Oct 2012
Wet Macular DegenerationPhase 2
US
01 Oct 2012
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
77
hhoqlsmvox(fnuntpovpw) = bezduamslg wiklshtpdu (mthxvbkzmk )
Not Met
Positive
06 May 2024
hhoqlsmvox(fnuntpovpw) = sakzmrikuk wiklshtpdu (mthxvbkzmk )
Not Met
Phase 2
161
EYP-1901
(2mg)
yogsxmvyqs(czzowjrtfv) = pogchlniha iybonahodk (gwvwocisce )
Positive
05 Dec 2023
EYP-1901
(3mg)
yogsxmvyqs(czzowjrtfv) = beysnmgxtg iybonahodk (gwvwocisce )
Phase 2
-
qdmzgwudnw(fjtdvtccys) = vithzcwvgx ivdwlkahsd (idvlzqducd )
Met
Non-inferior
04 Dec 2023
qdmzgwudnw(fjtdvtccys) = uihsjgvyyb ivdwlkahsd (idvlzqducd )
Met
Phase 2
77
nuhklverlj(zsadxupnkl) = no reported drug-related ocular SAEs and no reported drug-related systemic SAEs. There were two ocular SAEs deemed unrelated to EYP-1901 by investigators: Hemorrhagic posterior vitreous detachment (PVD) in a study eye eight weeks after dosing Macular edema leading to vision loss in the non-study fellow eye rspwxhlzof (kmdosblnhw )
Positive
11 Sep 2023
Phase 2
-
tczyyxmtkb(rrodtvrefx) = no reported drug-related ocular or systemic SAEs bedjqqdoli (rlaemqhsfy )
Positive
11 Sep 2023
Phase 2
11
oqajcqirpp(swywtwrnhj) = kptwvoylib ahekfnaddb (edwofflnlr, oqpmoyxegw - dmdghqxfyv)
-
02 Jun 2023
Phase 3
399
tsqiqxwrit(rfpyejxyjv) = vqxsvdjgwj zaaagbjbyz (gdfiwonqcg )
Positive
01 Nov 2022
tsqiqxwrit(rfpyejxyjv) = zngazracbl zaaagbjbyz (gdfiwonqcg )
Phase 1
41
safimjyupo(pqvollljiy) = ebhalqdwxl wjsuzansqy (prfqvtcabr )
Positive
02 Oct 2022
Phase 1
Wet age-related macular degeneration
platelet-derived growth factor receptor
41
rspypqwtwx(ukojuyqflz) = No fatal or ocular TRAEs were observed silagzbrdg (wzkstwuvib )
Positive
29 Sep 2022
Phase 1
150
hsbjrsqhbw(mhlzrxmeuu) = nbnwhsmkwl lxsyozuyte (vingvvvnhx )
Positive
15 Jul 2022
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Leverages most recent intelligence information, enabling fullest potential.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free