Drug Type Small molecule drug |
Synonyms Acotiamide, Acotiamide hydrochloride (USAN), Acotiamide hydrochloride hydrate (JAN) + [8] |
Action antagonists, inhibitors |
Mechanism A1R antagonists(Adenosine A1 receptor antagonists), AChE inhibitors(Acetylcholinesterase inhibitors), M1 receptor antagonists(Muscarinic acetylcholine receptor M1 antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date Japan (25 Mar 2013), |
Regulation- |
Molecular FormulaC21H37ClN4O8S |
InChIKeyNPTDXIXCQCFGKC-UHFFFAOYSA-N |
CAS Registry773092-05-0 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D08838 | Acotiamide Hydrochloride Hydrate |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Dyspepsia | Japan | 25 Mar 2013 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Postprandial distress syndrome | Phase 3 | Belgium | 01 Mar 2014 | |
Postprandial distress syndrome | Phase 3 | Bulgaria | 01 Mar 2014 | |
Postprandial distress syndrome | Phase 3 | Latvia | 01 Mar 2014 | |
Postprandial distress syndrome | Phase 3 | Lithuania | 01 Mar 2014 | |
Postprandial distress syndrome | Phase 3 | Romania | 01 Mar 2014 | |
Postprandial distress syndrome | Phase 3 | Russia | 01 Mar 2014 | |
Postprandial distress syndrome | Phase 3 | Slovakia | 01 Mar 2014 | |
Postprandial distress syndrome | Phase 3 | Sweden | 01 Mar 2014 | |
Postprandial distress syndrome | Phase 3 | Ukraine | 01 Mar 2014 | |
Postprandial distress syndrome | Phase 3 | United Kingdom | 01 Mar 2014 |
Not Applicable | - | (Patients with EGJOO) | anovqgalaa(pbipwvrcpe) = Acotiamide was administered to address severe symptoms in six out of 13 patients with EGJOO. Acotiamide normalized impaired receptive LES relaxation and substantially improved symptoms. tatgtmsrmp (qsczkfskef ) | - | 01 Oct 2016 | ||
(Normal subjects) | |||||||
Not Applicable | - | Acotiamide 10 mg thrice daily | qisrvrdvzp(wurmtxqitz) = zqazkpfwvh cegmwwohyi (efwhrkdmfn ) | - | 01 Oct 2016 | ||
Placebo | qisrvrdvzp(wurmtxqitz) = qnrvkebaqy cegmwwohyi (efwhrkdmfn ) | ||||||
Not Applicable | 50 | hddorqanuq(wsqpohuzyo) = auiapetqhc wjsfruyawr (fhuknlisco ) View more | Positive | 01 Oct 2016 | |||
Placebo | hddorqanuq(wsqpohuzyo) = zjmmpizkcw wjsfruyawr (fhuknlisco ) View more | ||||||
Phase 3 | - | hxlokwmbhr(jejzefpuju) = qjadfnshdp rqkcplkgnf (zgmpqjfked ) | Positive | 01 Jun 2012 | |||
Placebo | hxlokwmbhr(jejzefpuju) = xlkuykglai rqkcplkgnf (zgmpqjfked ) |