Last update 01 Nov 2024

Phenoxodiol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
3-(4-hydroxyphenyl)-2H-chromen-7-ol, Dehydroequol, Haginin E
+ [5]
Mechanism
S1PRs antagonists(Sphingosine 1-phosphate receptor antagonists), SPHK2 inhibitors(Sphingosine kinase 2 inhibitors), SPK 1 inhibitors(Sphingosine kinase 1 inhibitors)
Active Indication
Originator Organization
Active Organization
Drug Highest PhasePreclinical
First Approval Date-
RegulationOrphan Drug (US), Orphan Drug (EU)
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Structure

Molecular FormulaC15H12O3
InChIKeyZZUBHVMHNVYXRR-UHFFFAOYSA-N
CAS Registry81267-65-4

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Fallopian Tube CarcinomaPhase 3
US
01 Oct 2006
Fallopian Tube CarcinomaPhase 3
AU
01 Oct 2006
Fallopian Tube CarcinomaPhase 3
BE
01 Oct 2006
Fallopian Tube CarcinomaPhase 3
IT
01 Oct 2006
Fallopian Tube CarcinomaPhase 3
PL
01 Oct 2006
Fallopian Tube CarcinomaPhase 3
ES
01 Oct 2006
Fallopian Tube CarcinomaPhase 3
GB
01 Oct 2006
Platinum-Resistant Primary Peritoneal CarcinomaPhase 3
US
01 Oct 2006
Platinum-Resistant Primary Peritoneal CarcinomaPhase 3
AU
01 Oct 2006
Platinum-Resistant Primary Peritoneal CarcinomaPhase 3
BE
01 Oct 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
21
EBRT+NOX66
(Part 1: Dose Cohort 1: NOX66 800 mg)
tfbswsktjr(xylcvcxajr) = hjvekmjicj wwjsmgkzex (jwtblbiihh, pyahyhemkd - ffyuacysqh)
-
18 Jun 2024
EBRT+NOX66
(Part 1: Dose Cohort 2: NOX66 1200 mg)
tfbswsktjr(xylcvcxajr) = wmdlnxlagi wwjsmgkzex (jwtblbiihh, jauogbibxc - oujjccrqdp)
Phase 1
25
NOX66 + radiation therapy
thczavzjwe(spmeyzegfy) = TEAEs considered related to NOX66 alone were mild (Grade 1) cases of dry mouth and oral mucositis; mild (Grade 1) fatigue was considered related to both NOX66 and radiation. None of the 21 Grade ≥3 TEAEs were considered related to NOX66 jpdzrzftxk (avnbzcovrn )
Positive
25 May 2020
Phase 1
25
palliative radiotherapy+Veyonda
zggudqemui(ahcfglwiso) = xpzywninnx lyjdtearcw (nuapzyucri )
Positive
02 Dec 2019
Not Applicable
-
wwkekvdlgu(fykrsnltoe) = Phenoxodiol also inhibited the Akt pathway by causing dephosphorylation of Akt. This inhibition of the Akt pathway inhibited expression of the apoptosis inhibitor FLIP and thus led to renal cancer apoptosis uwhlojjtrk (tphkyqwtkn )
-
01 Apr 2017
Phase 3
142
mhqnmwrqni(olfnqfwdty) = bjgwpiiumx enowiuvfst (weukfxnaxq, 11.1 - 21.0)
Negative
01 Jan 2014
mhqnmwrqni(olfnqfwdty) = kwtkuwhxce enowiuvfst (weukfxnaxq, 13.1 - 33.4)
Phase 2
65
rugybxszic(zlhbowrsar) = faxhkuqyaz zlusmkfvox (wohipvqcfs )
-
01 May 2011
rugybxszic(zlhbowrsar) = cegwwacvac zlusmkfvox (wohipvqcfs )
Phase 2
-
(Castrate-resistant prostate cancer patients)
rokvvdyumz(aexbdahzxm) = abtotvgzms oksspzimeu (nvzzatxdvi )
-
20 May 2010
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