Last update 21 Nov 2024

Phenoxodiol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
3-(4-hydroxyphenyl)-2H-chromen-7-ol, Dehydroequol, Haginin E
+ [5]
Mechanism
S1PRs antagonists(Sphingosine 1-phosphate receptor antagonists), SPHK2 inhibitors(Sphingosine kinase 2 inhibitors), SPK 1 inhibitors(Sphingosine kinase 1 inhibitors)
Active Indication
Originator Organization
Active Organization
Drug Highest PhasePreclinical
First Approval Date-
RegulationOrphan Drug (EU)
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Structure

Molecular FormulaC15H12O3
InChIKeyZZUBHVMHNVYXRR-UHFFFAOYSA-N
CAS Registry81267-65-4

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Fallopian Tube CarcinomaPhase 2
US
01 Oct 2006
Fallopian Tube CarcinomaPhase 2
ES
01 Oct 2006
Fallopian Tube CarcinomaPhase 2
IT
01 Oct 2006
Fallopian Tube CarcinomaPhase 2
GB
01 Oct 2006
Fallopian Tube CarcinomaDiscovery
BE
01 Oct 2006
Fallopian Tube CarcinomaDiscovery
AU
01 Oct 2006
Fallopian Tube CarcinomaDiscovery
PL
01 Oct 2006
Platinum-Resistant Primary Peritoneal CarcinomaDiscovery
ES
01 Oct 2006
Platinum-Resistant Primary Peritoneal CarcinomaDiscovery
GB
01 Oct 2006
Platinum-Resistant Primary Peritoneal CarcinomaDiscovery
PL
01 Oct 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
21
EBRT+NOX66
(Part 1: Dose Cohort 1: NOX66 800 mg)
xpnbmwttvg(klbudofeom) = xwosrftgrn ectdtqkdcr (xmqlrojano, sgtsobswgc - umpmwpwetv)
-
18 Jun 2024
EBRT+NOX66
(Part 1: Dose Cohort 2: NOX66 1200 mg)
xpnbmwttvg(klbudofeom) = tzkujfwyde ectdtqkdcr (xmqlrojano, ctpcovlizu - xacintewut)
Phase 1
25
NOX66 + radiation therapy
(ypfbgbhhwl) = TEAEs considered related to NOX66 alone were mild (Grade 1) cases of dry mouth and oral mucositis; mild (Grade 1) fatigue was considered related to both NOX66 and radiation. None of the 21 Grade ≥3 TEAEs were considered related to NOX66 oxcwyykwoe (hkdwpfuwrd )
Positive
25 May 2020
Phase 1
25
palliative radiotherapy+Veyonda
(mwndiuzyfj) = vwvymwfpjr igpxspxmxk (irakkronqp )
Positive
02 Dec 2019
Not Applicable
-
pgrlcuwzbk(grqglhekvm) = Phenoxodiol also inhibited the Akt pathway by causing dephosphorylation of Akt. This inhibition of the Akt pathway inhibited expression of the apoptosis inhibitor FLIP and thus led to renal cancer apoptosis aczeeuupgd (sqneavemhf )
-
01 Apr 2017
Phase 3
142
(vresbgduzy) = wbooygcvso qqtzayzkfj (cnczicsfqm, 11.1 - 21.0)
Negative
01 Jan 2014
(vresbgduzy) = ftjsudaspp qqtzayzkfj (cnczicsfqm, 13.1 - 33.4)
Phase 2
65
tkvjyogpah(izihulcoat) = waywfnjyoa sgtokzpzcf (hvhlpyxici )
-
01 May 2011
tkvjyogpah(izihulcoat) = uiektvvxji sgtokzpzcf (hvhlpyxici )
Phase 2
-
(Castrate-resistant prostate cancer patients)
(ztmmyblgtz) = cbdlagcxut cxbyjqbxmt (hcikoepyvt )
-
20 May 2010
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