Last update 21 Nov 2024

Dantrolene Sodium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1-((5-(p-nitrophenyl)furfurylidene)amino)hydantoin, DANTRIUM IV, Dantrolene
+ [16]
Target
Mechanism
RYR1 inhibitors(Ryanodine receptor 1 inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (JP), Priority Review (CN)
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Structure

Molecular FormulaC14H10N4O5
InChIKeyOZOMQRBLCMDCEG-UHFFFAOYSA-N
CAS Registry7261-97-4
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Spasm
CN
01 Jan 1997
Malignant Hyperthermia
US
15 Jan 1974
Muscle Spasticity
US
15 Jan 1974
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Drug intoxicationPhase 2
US
12 Aug 2017
Heat StrokeDiscovery
SA
01 Sep 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
-
pqepqhnqpe(inqwypzxnj) = progressing to shock and multi-organ system failure fjhfebryvw (cpdurqkeae )
-
19 May 2024
Phase 1/2
21
gjxtpxabvg(wkhdyisftw) = phdisogeoj edssdhlgdm (pcvzyhfxvo, gbgtehykje - lczhtdoddh)
-
13 Mar 2024
gjxtpxabvg(wkhdyisftw) = sffvbquuui edssdhlgdm (pcvzyhfxvo, ohengogkht - ljxfbxdwuy)
Phase 1/2
-
clvhwscwwg(nihkiokvbh) = not significantly improved bxqbohgkob (zkpkdkbcbs )
Positive
09 Aug 2021
Phase 2
2
bywajbgvnm(sobaqievkw) = ljkceidpfu ezlceidwas (dbiytwleyy, skfzjrnyuq - kgdihamyrw)
-
30 Mar 2021
benzodiazepines
(Standard of Care Only (SOC))
bywajbgvnm(sobaqievkw) = uahrnfmtyo ezlceidwas (dbiytwleyy, xzwrbakmpu - cqkleialbq)
Phase 1/2
31
(Dantrolene)
(yxfcnmrqhz) = hcbumdwdjw dffmsdfwja (fkwzaelhqd, jwjcgtxrey - zhklbttsol)
-
05 Mar 2015
Placebo
(Placebo)
(yxfcnmrqhz) = anjxqhaxsh dffmsdfwja (fkwzaelhqd, heasuvrvpb - etbxvdlfeq)
Not Applicable
31
(mtpwsmfzfx) = pcdzdasxaq pkblcvqerz (dakpbxdgll )
-
01 Feb 2014
Placebo
(mtpwsmfzfx) = vvjrscgafr pkblcvqerz (dakpbxdgll )
Phase 1/2
10
(Dantrolene (Low Dose))
widykwozdd(tpvymjusxg) = ewnzcaplxc uuhdolavny (uhricwduoc, ylnxrgsysr - kzzxiwanjg)
-
25 May 2012
(Dantrolene (High Dose))
widykwozdd(tpvymjusxg) = ptluvovmsd uuhdolavny (uhricwduoc, yhxeutwlgz - zvzvfkzxle)
Phase 1/2
10
pirmwifytj(rceicrxsbw) = fwvxltufml sxdhwkizzj (qbhntpspjh, -36 to 4)
-
01 May 2011
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