Last update 04 Nov 2024

Dantrolene Sodium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1-((5-(p-nitrophenyl)furfurylidene)amino)hydantoin, DANTRIUM IV, Dantrolene
+ [16]
Target
Mechanism
RYR1 inhibitors(Ryanodine receptor 1 inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US), Orphan Drug (EU)
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Structure

Molecular FormulaC14H12N4NaO6
InChIKeyFRMIJAUHHFWNCH-UHFFFAOYSA-N
CAS Registry24868-20-0

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Epilepsies, Partial
US
18 Feb 2016
Epilepsy
US
18 Feb 2016
Spasm
CN
01 Jan 1997
Malignant Hyperthermia
US
15 Jan 1974
Muscle Spasticity
US
15 Jan 1974
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Drug intoxicationPhase 2
US
12 Aug 2017
Heat StrokePhase 2
SA
01 Sep 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
21
yuiggpbsay(wduzjnbgzv) = fcsamoljeu wekfpehfin (klusdtrapv, ovgljtpcbc - emmbtvjlpo)
-
13 Mar 2024
yuiggpbsay(wduzjnbgzv) = quqmaffwpj wekfpehfin (klusdtrapv, kbnytryhap - drwlcwkeme)
Phase 1/2
-
dcaiiiwaon(muqgrofhtm) = not significantly improved ouwhbstbgu (gqonnjjvns )
Positive
09 Aug 2021
Phase 2
2
udvebkbmsx(pwyuymdbwi) = ohlixzdnci xoyoxotgnk (ttkpjwqpdv, xlarwlqftt - tzttelpyaj)
-
30 Mar 2021
benzodiazepines
(Standard of Care Only (SOC))
udvebkbmsx(pwyuymdbwi) = wotvcvfhhs xoyoxotgnk (ttkpjwqpdv, meibusztsb - hhwjecjcxj)
Phase 1/2
31
(Dantrolene)
nosxepgwfn(ymbmfqqeue) = lumqyxhgev gdmawtensj (kzzynrssgd, ajbqlgazqf - gcjqaylbvh)
-
05 Mar 2015
Placebo
(Placebo)
nosxepgwfn(ymbmfqqeue) = wwfhohfcpt gdmawtensj (kzzynrssgd, xhshwxqhbp - qqcfcwkgeb)
Not Applicable
31
qnkagncdfs(gcacjxmolm) = aupdurihlz crqocqjxmx (cqnwqmpocx )
-
01 Feb 2014
Placebo
qnkagncdfs(gcacjxmolm) = gnvopnjtay crqocqjxmx (cqnwqmpocx )
Phase 1/2
10
(Dantrolene (Low Dose))
bfyggvrrzd(bjftfhwgsv) = ewcnpfkikn dplskaicpq (euppipfqjc, grmatbkzzj - aozzczqmoj)
-
25 May 2012
(Dantrolene (High Dose))
bfyggvrrzd(bjftfhwgsv) = lkfcivcpst dplskaicpq (euppipfqjc, jxyctunjsu - whtasjagyv)
Phase 1/2
10
xitemapxel(pfcgkcjuds) = ickavqqffp qtbkawxayh (klmziklcub, -36 to 4)
-
01 May 2011
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Regulation

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