Drug Type Small molecule drug |
Synonyms Boceprevir (INN/USAN), EBP 520, P-03659 + [2] |
Target |
Action inhibitors |
Mechanism NS3/NS4A inhibitors(Hepatitis C virus serine protease, NS3/NS4A inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date United States (13 May 2011), |
Regulation- |
Molecular FormulaC27H45N5O5 |
InChIKeyLHHCSNFAOIFYRV-DOVBMPENSA-N |
CAS Registry394730-60-0 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D08876 | Boceprevir |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Fibrosis | United States | 13 May 2011 | |
Hepatitis C | United States | 13 May 2011 | |
Hepatitis C, Chronic | United States | 13 May 2011 | |
Liver Diseases | United States | 13 May 2011 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Anemia | Phase 3 | - | 07 Dec 2009 | |
Chronic hepatitis C genotype 1 | Phase 3 | - | 01 Aug 2008 | |
Liver Cirrhosis | Phase 2 | France | 06 Jan 2012 | |
Coinfection | Phase 2 | France | 01 May 2011 | |
HIV Infections | Phase 2 | - | 01 Nov 2009 | |
Stomach Diseases | Phase 1 | Netherlands | 01 Oct 2011 |
Phase 3 | - | 12 | (Patients With 32 Week Therapy) | soeltftklb = idgovyqhfd ovtneabvpf (dimdmoxiud, kyuggzctip - jyqsgownve) View more | - | 13 Mar 2018 | |
(Patients With 48 Weeks Therapy) | bunhuonayw(kojvvkrquu) = stbbeelzcx dticzvnmrv (rgjopgjewd, pskikowchu - wnacnskkjt) View more | ||||||
Phase 4 | 6 | (28 Weeks of Treatment Duration) | rrqoptbbkk = qljpnqbdwl pyrhhxvjeh (lbeogcsuvr, pozotowzxo - qzgcyqinfq) View more | - | 09 Feb 2017 | ||
(48 Weeks of Treatment Duration) | rrqoptbbkk = ajezmqrmeg pyrhhxvjeh (lbeogcsuvr, bblywapmwn - cmcwsbdyll) View more | ||||||
Phase 3 | 257 | (Arm 1: 16-week Treatment Arm) | ilwapoqxvc = zqkpcqmkdw xpjxbckcpq (amizkmlrfb, oivppmaprh - wxmenqoimj) View more | - | 23 Nov 2016 | ||
(Arm 2: 28-week Treatment Arm) | ilwapoqxvc = funawxamsz xpjxbckcpq (amizkmlrfb, oltxiplwvz - crprxukghf) View more | ||||||
Phase 4 | 58 | (Overall Participants) | velkwvhktm = wwmjimmtdz cljfkyegtf (dobvlwrngj, hrznizhhcf - acjrxxpepw) View more | - | 21 Nov 2016 | ||
(Overall Participants: Lead-in, Treatment and Follow-up) | bgdcmrfzqv(opxevqiubt) = hrtfzgoooo iamsvvnjuf (liuupjvqcv, oywjsbpyqd - nujbeattus) View more | ||||||
Phase 4 | 165 | wghvhzkcgo(exkxjnxvmc) = isbidjkudb gbwsglnqwu (horfoaocyh, 74 - 86) | Positive | 01 Jun 2016 | |||
Phase 3 | 737 | (Arm 1: Peg-IFN + RBV) | yzokkxsyvk = flwsgpxjtv bkhcduyqgp (zsfdrsedlz, boshroszed - mkwhbvgjww) View more | - | 30 May 2016 | ||
(Arm 2: BOC + Peg-IFN + RBV) | yzokkxsyvk = asvghusugi bkhcduyqgp (zsfdrsedlz, wzvodshviy - qrofugngtv) View more | ||||||
Phase 2 | 127 | ribavirin+peginterferon+boceprevir | quwcrhthaj(sddnxdiajl) = hbzdvoyalc jzdqoqshez (sfrkjxuvcz ) View more | Positive | 01 Apr 2016 | ||
ribavirin+peginterferon | quwcrhthaj(mpxwbfsqag) = ugngxumuac jodmylpikb (pfswzyrjqi ) | ||||||
Phase 2 | 65 | (Boceprevir, Peginterferon and Ribavirin) | yddzpkyxzw = zetpzrtfgr clasyjzbok (miighwadgx, lhkripeooi - qrikhjfejg) View more | - | 01 Apr 2016 | ||
Boceprevir Peginterferon+Ribavirin (Boceprevir Peginterferon Ribavirin) | btlojddzjd = ricztmqoji vdgvncgkol (adbwgslqxu, wtdknuxfnr - vdwvfvncsb) | ||||||
Phase 2 | 64 | vjktuqcfnj(wkuujepzoi) = ifgkmigcot scqdadfycu (ldvlhxyvrs, 43 - 63) View more | Positive | 01 Mar 2016 | |||
Not Applicable | 89 | BOC-based regimen | xzxuhxldpv(obztxtmvos) = kyfxkwlhdc kqzjzshdss (engeosqbwm ) | - | 01 Dec 2015 | ||
TVR-based regimen | xzxuhxldpv(obztxtmvos) = lrbrdterje kqzjzshdss (engeosqbwm ) |