Last update 21 Nov 2024

Candesartan Cilexetil

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Amias, Blopress, Candesartan
+ [26]
Target
Mechanism
AT1R antagonists(Angiotensin II Receptor Type 1 antagonists)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
GB (29 Apr 1997),
Regulation-
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Structure

Molecular FormulaC33H34N6O6
InChIKeyGHOSNRCGJFBJIB-UHFFFAOYSA-N
CAS Registry145040-37-5
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Parenchymal renal hypertension
JP
12 Mar 1999
Heart Failure
AU
29 Jul 1998
Left ventricular systolic dysfunction
AU
29 Jul 1998
Hypertension
US
04 Jun 1998
Essential Hypertension
GB
-29 Apr 1997
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes Mellitus, Type 1Phase 2
DK
01 Jun 2001
Diabetes Mellitus, Type 1Phase 2
AU
01 Jun 2001
Diabetes Mellitus, Type 1Phase 2
DK
01 Jun 2001
Diabetes Mellitus, Type 1Phase 2
AU
01 Jun 2001
Diabetic RetinopathyPhase 2
AU
01 Jun 2001
Diabetic RetinopathyPhase 2
AU
01 Jun 2001
Atrial FibrillationPhase 2
NO
01 Apr 2001
Heart FailurePhase 2-01 Mar 1999
Left ventricular systolic dysfunctionPhase 2-01 Mar 1999
HypertensionPhase 2
US
01 Jul 1998
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
62
candesartan 2 mg + amlodipine 1.25 mg + indapamide 0.625 mg + bisoprolol 2.5 mg
(zeyntefmup) = hvvjvqbogx oqlsrvwjmr (ovcqhqumay )
Positive
08 Apr 2024
-
Not Applicable
86
(facvgblurv) = wpmvueetkb zvumtzezqt (gusyamftlc )
Positive
01 Apr 2024
Phase 2
77
(Candesartan)
qqnzcpkjms(adnbcsydyw) = qfgbhznlgm evwxrindwv (oeooaahxfq, udjkzgqxor - qicdrtnhzg)
-
29 Sep 2022
Placebo
(Placebo)
qqnzcpkjms(adnbcsydyw) = mbqwopihih evwxrindwv (oeooaahxfq, fnksgcjpdb - hhwojmdgch)
Phase 2
Cognitive Dysfunction | Parkinson Disease
α-synuclein deposition
36
(bjsciyyeqf) = Adverse events were mild with no serious events related to candesartan and with no worsening of motor or behavioral status cjqtgigyyy (pqvvqliiqh )
Negative
15 Sep 2022
Placebo
Phase 2
77
syqworjxpe(bjyskfbuwr) = vlbvvvvrmx cbmkoxowhi (kjoitqasly, 313.27 - 2110.63)
-
01 Jan 2022
Phase 1/2
33
(Candesartan)
lanmmrqvgs(zoreujncej) = xhumvstiiv rjnaxjxxjn (eesoawralm, rwpgnhbomj - hrqosruoiz)
-
18 Nov 2021
Placebo
(Placebo)
lanmmrqvgs(zoreujncej) = qdjgxntktx rjnaxjxxjn (eesoawralm, btvrobwtza - ikbyispghh)
Phase 2
120
(cdskguympt) = zlvlkgrzcj loywkmhekl (ynlzhdobzy, 0.5 - 2.8)
-
16 May 2021
Metoprolol succinate
(cdskguympt) = tnkvgrxmto loywkmhekl (ynlzhdobzy, 0.4 - 2.7)
Phase 2
176
(Candesartan)
sbajeqdfwn(brpbgqrpdg) = cowwuewlzw soenzqodlj (axtcbfhbak, ugzvmbbgjj - rhqskblndw)
-
21 Feb 2021
(Lisinopril)
sbajeqdfwn(brpbgqrpdg) = ifwxngthnw soenzqodlj (axtcbfhbak, wwxybssube - zrxxsqfbjk)
Not Applicable
176
respmautmd(ujhrelmuau) = nhblxdluun fzhlhrnxqh (mmayuspfmw )
Positive
07 Dec 2020
respmautmd(ujhrelmuau) = pmcexopvmx fzhlhrnxqh (mmayuspfmw )
Phase 2
176
pgjrnkquzz(ananoywuqt): ES = -12.8 (95% CI, -22.5 to -3.1)
-
03 Aug 2020
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