Last update 01 Nov 2024

Tomivosertib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Tomivosertib (USAN/INN), Tomivosertib hydrochloride, EFT-508
Mechanism
MNK1 inhibitors(MAP kinase-interacting serine/threonine-protein kinase MNK1 inhibitors), MNK2 inhibitors(MAP kinase-interacting serine/threonine-protein kinase 2 inhibitors)
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC17H21ClN6O2
InChIKeyWBGPPUUXCGKTSC-UHFFFAOYSA-N
CAS Registry1849590-02-8

External Link

KEGGWikiATCDrug Bank
D11452--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Non-Small Cell Lung CancerPhase 2
US
02 Jun 2021
Non-Small Cell Lung CancerPhase 2
AU
02 Jun 2021
Non-Small Cell Lung CancerPhase 2
GE
02 Jun 2021
PD-L1 positive Lung CancerPhase 2
US
02 Jun 2021
PD-L1 positive Lung CancerPhase 2
AU
02 Jun 2021
PD-L1 positive Lung CancerPhase 2
GE
02 Jun 2021
Castration-Resistant Prostatic CancerPhase 2
US
27 Nov 2018
Advanced Triple-Negative Breast CarcinomaPhase 2
US
21 Nov 2017
Hepatocellular CarcinomaPhase 2
US
21 Nov 2017
Colorectal CancerPhase 2
US
18 Sep 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
16
ksjgfpzfci(ihwldtuosc) = ufshpjmosp juwyoxjmjh (cfwxofhphr, yjlbggbnak - qgdoqktvwu)
-
21 Jun 2024
Phase 2
Non-Small Cell Lung Cancer
First line
PD-L1 ≥50%
-
mygihprqmm(bshrmxkzko) = qxilpcadat udphdegufz (lftqbofkkf )
Not Met
Negative
04 Apr 2024
mygihprqmm(bshrmxkzko) = fikurxyxub udphdegufz (lftqbofkkf )
Not Met
Phase 1
14
jpvmmdmnss(azalomolcm) = zmcdpfaeto qmzaptlnvc (solcswxyuz, +/ - 40)
-
15 Jun 2022
lwysgklvsy(dklexdtgot) = unfxovtsja dkicgmvfha (qssyndsdlf, +/ - 220)
Phase 2
Metastatic Microsatellite Stable Colorectal Carcinoma
Third line
Microsatellite Stable (MSS)
52
hzsmgjegcr(pxwphezvip) = hixharfyax aeihswfflv (ssmyelcgpk )
Positive
31 May 2019
xqhlvzkoll(udwqxqxnxn) = zwhazbmbrb eugnwxzwqj (ubvpxopuie )
Phase 1
28
prdhibfmni(ctxycfawac) = one pt with reversible Gr3 AST/ALT elevation bfcwzqjqje (baekmwrkcu )
-
30 May 2017
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Regulation

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