Last update 21 Nov 2024

AZD-8186

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Mechanism
PI3Kβ inhibitors(Phosphatidylinositol 3 kinase beta inhibitors), PI3Kδ inhibitors(Phosphatidylinositol 3 kinase delta inhibitors)
Originator Organization
Active Organization
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Structure

Molecular FormulaC24H25F2N3O4
InChIKeyLMJFJIDLEAWOQJ-CQSZACIVSA-N
CAS Registry1627494-13-6

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Gastric AdenocarcinomaPhase 2
KR
14 May 2019
Castration-Resistant Prostatic CancerPhase 2
ES
09 Jul 2013
Castration-Resistant Prostatic CancerPhase 2
GB
09 Jul 2013
Castration-Resistant Prostatic CancerPhase 2
CA
09 Jul 2013
Castration-Resistant Prostatic CancerPhase 2
US
09 Jul 2013
Triple Negative Breast CancerPhase 2
CA
09 Jul 2013
Triple Negative Breast CancerPhase 2
GB
09 Jul 2013
Triple Negative Breast CancerPhase 2
US
09 Jul 2013
Triple Negative Breast CancerPhase 2
ES
09 Jul 2013
Solid tumorPhase 2--
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
23
keirpmuflb(cqrzcajoqk) = dcxafboebl rqpzkyfupu (apqmtatbnv, yagqqligzp - dpropdiskh)
-
21 Sep 2023
sziulyrvna(aypxqtdbxf) = smyhqmwpnb ydhvysgrob (uzfibouunv, tisxngdgfp - xtuavmrzfj)
Phase 1/2
52
abiraterone acetate+prednisone+AZD8186
(rdehsnqcrd) = diarrhoea (39%) and nausea (27%) ofnzfctrbw (jubkdfyvbj )
Positive
22 Oct 2018
Phase 1
87
(kohmzaiddq) = 23 SAEs considered jmmgtwyfpg (nklmipnxvy )
Positive
05 Jun 2017
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Approval

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Regulation

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