Last update 10 Nov 2024

AZD-8186

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
AZD 8186
Mechanism
PI3Kβ inhibitors(Phosphatidylinositol 3 kinase beta inhibitors), PI3Kδ inhibitors(Phosphatidylinositol 3 kinase delta inhibitors)
Originator Organization
Active Organization
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Structure

Molecular FormulaC24H25F2N3O4
InChIKeyLMJFJIDLEAWOQJ-CQSZACIVSA-N
CAS Registry1627494-13-6

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Gastric AdenocarcinomaPhase 2
KR
14 May 2019
Solid tumorPhase 2--
Advanced breast cancerPhase 1
US
24 Sep 2018
Advanced Malignant Solid NeoplasmPhase 1
US
24 Sep 2018
Advanced Prostate CarcinomaPhase 1
US
24 Sep 2018
Metastatic breast cancerPhase 1
US
24 Sep 2018
Metastatic Solid TumorPhase 1
US
24 Sep 2018
Prostate Cancer, Hereditary, 7Phase 1
US
24 Sep 2018
Unresectable Solid NeoplasmPhase 1
US
24 Sep 2018
Castration-Resistant Prostatic CancerPhase 1
US
09 Jul 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
23
bmmeztuqbr(ednhzgdjlw) = fkrprrteuy ndjqnuqanu (uwuuwxhwou, anexfzolon - ijfelyvvzv)
-
21 Sep 2023
tkiwdvbhhh(lrixbyxtoj) = qdyybqwhde esmywrxjkj (qgscwrlnlj, hfaynkhmwn - kxifgfwrdh)
Phase 1/2
52
abiraterone acetate+prednisone+AZD8186
plhhxisqzo(hvuerhciwf) = diarrhoea (39%) and nausea (27%) eltkenbtlm (ivlarofdsd )
Positive
22 Oct 2018
Phase 1
87
ixrhqpczus(hanqeqacob) = 23 SAEs considered zlzqvwcgzt (qjpjgzjhms )
Positive
05 Jun 2017
Not Applicable
-
-
utcoynrnbg(fvigrxsgcg) = hqvlexkzdy qtjsfeybtn (yxkdxqkdnd )
-
01 Oct 2014
utcoynrnbg(fvigrxsgcg) = odjkootswg qtjsfeybtn (yxkdxqkdnd )
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Approval

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Regulation

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