Drug Type Small molecule drug |
Synonyms AZD 8186 |
Target |
Mechanism PI3Kβ inhibitors(Phosphatidylinositol 3 kinase beta inhibitors), PI3Kδ inhibitors(Phosphatidylinositol 3 kinase delta inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 1 |
First Approval Date- |
Regulation- |
Molecular FormulaC24H25F2N3O4 |
InChIKeyLMJFJIDLEAWOQJ-CQSZACIVSA-N |
CAS Registry1627494-13-6 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Advanced Gastric Adenocarcinoma | Phase 2 | KR | 14 May 2019 | |
Solid tumor | Phase 2 | - | - | |
Advanced breast cancer | Phase 1 | US | 24 Sep 2018 | |
Advanced Malignant Solid Neoplasm | Phase 1 | US | 24 Sep 2018 | |
Advanced Prostate Carcinoma | Phase 1 | US | 24 Sep 2018 | |
Metastatic breast cancer | Phase 1 | US | 24 Sep 2018 | |
Metastatic Solid Tumor | Phase 1 | US | 24 Sep 2018 | |
Prostate Cancer, Hereditary, 7 | Phase 1 | US | 24 Sep 2018 | |
Unresectable Solid Neoplasm | Phase 1 | US | 24 Sep 2018 | |
Castration-Resistant Prostatic Cancer | Phase 1 | US | 09 Jul 2013 |
Phase 1 | 23 | (Dose Level 1) | bmmeztuqbr(ednhzgdjlw) = fkrprrteuy ndjqnuqanu (uwuuwxhwou, anexfzolon - ijfelyvvzv) View more | - | 21 Sep 2023 | ||
(Dose Level -1) | tkiwdvbhhh(lrixbyxtoj) = qdyybqwhde esmywrxjkj (qgscwrlnlj, hfaynkhmwn - kxifgfwrdh) View more | ||||||
NCT01884285 (ESMO2018) Manual | Phase 1/2 | 52 | abiraterone acetate+prednisone+AZD8186 | plhhxisqzo(hvuerhciwf) = diarrhoea (39%) and nausea (27%) eltkenbtlm (ivlarofdsd ) View more | Positive | 22 Oct 2018 | |
NCT01884285 (ASCO2017) Manual | Phase 1 | 87 | ixrhqpczus(hanqeqacob) = 23 SAEs considered zlzqvwcgzt (qjpjgzjhms ) View more | Positive | 05 Jun 2017 | ||
Not Applicable | - | - | utcoynrnbg(fvigrxsgcg) = hqvlexkzdy qtjsfeybtn (yxkdxqkdnd ) | - | 01 Oct 2014 | ||
utcoynrnbg(fvigrxsgcg) = odjkootswg qtjsfeybtn (yxkdxqkdnd ) |