Drug Type Small molecule drug |
Synonyms |
Target |
Mechanism PI3Kβ inhibitors(Phosphatidylinositol 3 kinase beta inhibitors), PI3Kδ inhibitors(Phosphatidylinositol 3 kinase delta inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 1 |
First Approval Date- |
Regulation- |
Molecular FormulaC24H25F2N3O4 |
InChIKeyLMJFJIDLEAWOQJ-CQSZACIVSA-N |
CAS Registry1627494-13-6 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Advanced Gastric Adenocarcinoma | Phase 2 | KR | 14 May 2019 | |
Castration-Resistant Prostatic Cancer | Phase 2 | ES | 09 Jul 2013 | |
Castration-Resistant Prostatic Cancer | Phase 2 | GB | 09 Jul 2013 | |
Castration-Resistant Prostatic Cancer | Phase 2 | CA | 09 Jul 2013 | |
Castration-Resistant Prostatic Cancer | Phase 2 | US | 09 Jul 2013 | |
Triple Negative Breast Cancer | Phase 2 | CA | 09 Jul 2013 | |
Triple Negative Breast Cancer | Phase 2 | GB | 09 Jul 2013 | |
Triple Negative Breast Cancer | Phase 2 | US | 09 Jul 2013 | |
Triple Negative Breast Cancer | Phase 2 | ES | 09 Jul 2013 | |
Solid tumor | Phase 2 | - | - |
Phase 1 | 23 | (Dose Level 1) | keirpmuflb(cqrzcajoqk) = dcxafboebl rqpzkyfupu (apqmtatbnv, yagqqligzp - dpropdiskh) View more | - | 21 Sep 2023 | ||
(Dose Level -1) | sziulyrvna(aypxqtdbxf) = smyhqmwpnb ydhvysgrob (uzfibouunv, tisxngdgfp - xtuavmrzfj) View more | ||||||
NCT01884285 (ESMO2018) Manual | Phase 1/2 | 52 | abiraterone acetate+prednisone+AZD8186 | (rdehsnqcrd) = diarrhoea (39%) and nausea (27%) ofnzfctrbw (jubkdfyvbj ) View more | Positive | 22 Oct 2018 | |
NCT01884285 (ASCO2017) Manual | Phase 1 | 87 | (kohmzaiddq) = 23 SAEs considered jmmgtwyfpg (nklmipnxvy ) View more | Positive | 05 Jun 2017 |