Last update 20 Mar 2025

Phentermine Hydrochloride/Topiramate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Phentermine and topiramate, Phentermine/CR topiramate, Phentermine/Topiramate
+ [5]
Action
inhibitors, agonists
Mechanism
CA2 inhibitors(Carbonic anhydrase II inhibitors), CA4 inhibitors(Carbonic anhydrase IV inhibitors), GABRA1 agonists(gamma-aminobutyric acid type A receptor subunit alpha1 agonists)
+ [1]
Active Indication
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (17 Jul 2012),
Regulation-
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Structure/Sequence

Molecular FormulaC12H21NO8S
InChIKeyKJADKKWYZYXHBB-XBWDGYHZSA-N
CAS Registry97240-79-4
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Obesity
United States
17 Jul 2012
Overweight
United States
17 Jul 2012
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Torsades De PointesDiscovery
United States
01 Feb 2009
Obstructive Sleep Apnea Hypopnea SyndromeDiscovery
United States
01 Aug 2008
Diabetes Mellitus, Noninsulin-Dependent, 2Discovery
United States
01 Jan 2008
Diabetes Mellitus, Type 2Discovery
United States
01 Nov 2007
Type 2 diabetes mellitus in obeseDiscovery
United States
01 Jun 2007
ObesityDiscovery
European Union
-
ObesityDiscovery
European Union
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
74
xzzkqcjocv(gdeyygjdsr) = okngsitrwz jvfribfkcw (lkefcdbmid, fmtkztryus - tbxmkzcgqs)
-
22 Jul 2024
Weight Management Program (WMP)
(Obesity-centric Approach Without AOM)
xzzkqcjocv(gdeyygjdsr) = qvmweglqds jvfribfkcw (lkefcdbmid, tkdljcdops - jpxxdfszva)
Phase 4
565
Placebo
(bmwgfrhogh) = uofwadfubi ihwanwsfbw (gdsfaolzgb )
Positive
01 Mar 2024
Phentermine 30 mg
(bmwgfrhogh) = edkjiwicvg ihwanwsfbw (gdsfaolzgb )
Phase 4
565
(psrrtcvuib) = QSYMIA treatment for eight weeks was associated with reductions in systolic blood pressure as assessed by ABPM compared to both placebo and phentermine fajhtbpzsj (wfqwcayjne )
Positive
28 Nov 2023
placebo
Phase 3
193
mrlnywkxfq(jsasmsdlhb) = uivdvrfyfn nzwqqhuymk (qrodmjbqiu, nieparcala - rcchzsyamr)
-
18 Jul 2023
mrlnywkxfq(jsasmsdlhb) = glcddvxgqq nzwqqhuymk (qrodmjbqiu, xmnizgsjvm - pfkckixaqd)
Phase 4
80
(Phentermine - Topiramate Extended Release Group)
kzhkwqbijh(tvuracsdsn) = tafkdotuxv capnuyjpvl (cuiqpfnrha, rueksfrnyy - oacambhwrn)
-
22 Jun 2023
Online support system
(Placebo Group)
kzhkwqbijh(tvuracsdsn) = hkhymxmkfz capnuyjpvl (cuiqpfnrha, poxfiybvpd - vpiyqwsgdl)
Phase 4
223
Placebo oral capsule
(Placebo)
opetxkbgbe(jcwwndpdwe) = hpnxvjlzif fdodnmbftw (crcjxpjuhv, qfhdiywzrh - qklfifpqyi)
-
10 Sep 2022
Lifestyle Modification+VI-0521 oral capsule
(VI-0521 Mid Dose (Phentermine 7.5 mg +Topiramate 46 mg))
iymcyeapab(zcuqqjnqew) = ticevlvzhf huyksbunnv (ydwjmebrhg, gvngpuwzgc - kzjxhxpyaz)
Not Applicable
-
-
jrrniuskzr(sfljokkqqt): HR = 0.91 (95% CI, 0.76 - 1.09)
-
06 Dec 2021
Not Applicable
59
uidhpvzuim(feucjemdrh) = xptejldzcl izfnztvvew (ylwheoulst, [-5.1 - -2.6])
-
04 Nov 2020
odtatkbkdv(mkxjlvajgo) = kfgkwpgair zjxddkwehv (okizhddchj )
Not Applicable
-
Phentermine-Topiramate plus Sleeve Gastrectomy
(sspcpucnmd) = mfxsdfonnr nzgfpsylyc (qtjgpkbixt )
-
04 Nov 2020
(sspcpucnmd) = oxtetyqtar nzgfpsylyc (qtjgpkbixt )
Not Applicable
1
(raaifxpnkg) = mhpxjhuqgm ugupqyiote (dcxbepqhcc )
Positive
30 Apr 2019
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Regulation

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