Last update 30 May 2025

Satricabtagene autoleucel

Overview

Basic Info

Drug Type
Autologous CAR-T
Synonyms
Anti-Claudin18.2-CAR-T cell therapy, CAR-CLD18 T cell therapy, CAR-CLDN18.2 T-Cells
+ [8]
Target
Action
inhibitors
Mechanism
CLDN18.2 inhibitors(Claudin 18.2 inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (United States), PRIME (European Union), Priority Review (China), Breakthrough Therapy (China), Regenerative Medicine Advanced Therapy (United States)
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Structure/Sequence

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Gastroesophageal junction adenocarcinomaPhase 2
China
04 Mar 2022
Advanced Gastric AdenocarcinomaPhase 2
United States
23 Oct 2020
Advanced Gastric AdenocarcinomaPhase 2
China
23 Oct 2020
Advanced Gastric AdenocarcinomaPhase 2
Canada
23 Oct 2020
Advanced Gastroesophageal Junction AdenocarcinomaPhase 2
China
23 Oct 2020
Pancreatic CancerPhase 2
United States
23 Oct 2020
Pancreatic CancerPhase 2
China
23 Oct 2020
Pancreatic CancerPhase 2
Canada
23 Oct 2020
stomach adenocarcinomaPhase 2
China
23 Oct 2020
CLDN18.2 positive Pancreatic CancerPhase 1
China
03 Aug 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
41
tisa-cel CAR-T细胞治疗
bnrjtavjvt(ipfoyantma) = nknwwtevjo wlgadljuhe (ztaenpvprl )
Positive
23 Jan 2025
Phase 2
Stomach Cancer
Last line | Third line
CLDN18.2 Positive
-
ehmuaurowo(uicgfcgimn) = 具有统计学意义上的显著改善。 enazapziac (glxgblxxhm )
Met
Positive
30 Dec 2024
研究者选择治疗组(包括紫杉醇、多西他赛、伊立替康、阿帕替尼或纳武利尤单抗)
Phase 1
98
qpcuhlorgx(ikyhehtwvi) = None gixqjrtezn (jexuzatdev )
Positive
03 Jun 2024
(dose-expansion stage)
Phase 1
Gastrointestinal Neoplasms
First line
CLDN18.2 Positive
98
CT041 in pretreated pts with advanced GI cancersCT041 in pretreated pts with advanced GI cancers
brtpvrfiye(uwttgxaqhh) = grade 3 or higher were hematologic toxicity related to lymphodepletion mopjjdufvc (kdcdrwmyuk )
Positive
24 May 2024
CT041 sequential treatment following first-line therapy in gastric cancer (GC)CT041 sequential treatment following first-line therapy in gastric cancer (GC)
Not Applicable
24
mttinpqbno(hyqnbmutot) = The most common treatment-emergent adverse events of grade 3 or more were preconditioning-related hematologic toxicities. Cytokine release syndrome (CRS) and GI disorders were most reported grade 1 or 2 adverse events. qfwwpatzgz (wajfdplaja )
Positive
24 May 2024
Phase 1/2
19
(GC/GEJ)
bjbqqacdfq(tfstjbzppo) = wdvnwbcpnh gwimhudevh (theeojokmo )
Positive
19 Jan 2024
(DL3:600×106)
vkplzopakw(cqaizvgtkk) = paldxcixhk zxxxhmfgyf (ugaolucier )
Phase 1/2
14
rvrheodvea(mnyjqeppif) = Most CRS were grade 1 or 2, and only one patient experienced grade 4 CRS and fully recovered shojkigzuq (iimdbdgpif )
Positive
02 Jun 2022
Phase 1
37
ckrkanzkto(lbfyfbhcll) = hematologic 100% mykrqwtejc (jefngywnou )
Positive
09 May 2022
Phase 1
37
guzcpiubgm(zxbxwoovgj) = hhryuoozgn rfqrqtmgzn (eocajmujcy )
Positive
19 Sep 2021
(patients with gastric cancer)
jmrzjbkjvg(cubcydrjtd) = bxeoitdyqy njiskdhhdy (rfxgdyebvv, 37.2 - 75.5)
Phase 1
12
autologous CAR-CLDN18.2 T cells
jsyhhplxcm(tdbbvwsghj) = none hutmyvrajg (lakrcburot )
Positive
04 Jun 2019
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Regulation

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