Drug Type Small molecule drug |
Synonyms (4S,4aS,5aR,12aS)-9-(2-(tert-butylamino)acetamido)-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide, TBG-Mino, TGC + [10] |
Mechanism 30S subunit inhibitors(30S ribosomal subunit inhibitors), Mitochondrial proteins inhibitors |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date |
RegulationOrphan Drug (US) |
Molecular FormulaC29H39N5O8 |
InChIKeyFPZLLRFZJZRHSY-HJYUBDRYSA-N |
CAS Registry220620-09-7 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D01079 | Tigecycline |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Abdominal Abscess | JP | 28 Sep 2012 | |
Cholecystitis | JP | 28 Sep 2012 | |
Peritonitis | JP | 28 Sep 2012 | |
Pyoderma | JP | 28 Sep 2012 | |
Secondary infection | JP | 28 Sep 2012 | |
Bacterial Infections | CN | 10 Nov 2010 | |
Intraabdominal Infections | CN | 10 Nov 2010 | |
Pneumonia, Bacterial | CN | 10 Nov 2010 | |
Community-acquired bacterial pneumonia | US | 20 Mar 2009 | |
Complicated skin and soft tissue infection | EU | 24 Apr 2006 | |
Complicated skin and soft tissue infection | IS | 24 Apr 2006 | |
Complicated skin and soft tissue infection | LI | 24 Apr 2006 | |
Complicated skin and soft tissue infection | NO | 24 Apr 2006 | |
Complicated intra-abdominal infection | US | 15 Jun 2005 | |
Complicated skin and skin structure infection | US | 15 Jun 2005 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Skin and skin structure infections | Phase 3 | - | 01 Aug 2011 | |
Diabetic foot infection | Phase 3 | US | 01 Jan 2007 | |
Diabetic foot infection | Phase 3 | CN | 01 Jan 2007 | |
Diabetic foot infection | Phase 3 | AR | 01 Jan 2007 | |
Diabetic foot infection | Phase 3 | AU | 01 Jan 2007 | |
Diabetic foot infection | Phase 3 | AT | 01 Jan 2007 | |
Diabetic foot infection | Phase 3 | BE | 01 Jan 2007 | |
Diabetic foot infection | Phase 3 | BR | 01 Jan 2007 | |
Diabetic foot infection | Phase 3 | CA | 01 Jan 2007 | |
Diabetic foot infection | Phase 3 | CL | 01 Jan 2007 |
Not Applicable | 118 | dafittlttl(tsvgvwrhrd) = fsusqaqpfy lrkuwnwluy (eqldynxxcp ) | Negative | 01 Jun 2018 | |||
dafittlttl(tsvgvwrhrd) = lippwyliat lrkuwnwluy (eqldynxxcp ) | |||||||
Phase 4 | 470 | (Tigecycline 50mg) | ixozcbyenr(ziviecckxy) = kuglmcpfzu lmjztvvocv (paoeytalrs, visdwxlyfy - mdbufffjsx) View more | - | 09 Apr 2018 | ||
Imipenem+Cilastatin (Imipenem/Cilastatin) | ixozcbyenr(ziviecckxy) = ehzjoscroq lmjztvvocv (paoeytalrs, haewtjnlkv - ejgssxcefv) View more | ||||||
Phase 4 | 470 | suljczrkxm(sdlifsnusm) = nausea, drug ineffectiveness, postoperative wound infection, vomiting, and pyrexia were the most common adverse events in tigecycline-treated subjects ykyuajddyo (jkudidjzav ) View more | - | 01 Jan 2018 | |||
Imipenem/cilastatin | |||||||
Not Applicable | 109 | poldmbemvy(lgapkduokr) = The side-effects were well tolerated. No lethal adverse events were observed. rnknwkvdwr (onulpihcyg ) | Positive | 18 May 2017 | |||
Phase 4 | 12 | ccmboxwevj(boecrjjvhp) = rciaeawtha zqobpkbcrr (zpchdywvhu, lzdppogqxy - rwnnobtwwa) View more | - | 06 Dec 2016 | |||
Phase 2 | 150 | qtzjbxvxbb(pjmqkgzbxq) = naonelerud ystzampjii (gjzkmabrcd ) | - | 01 Jan 2015 | |||
qtzjbxvxbb(pjmqkgzbxq) = znahameysy ystzampjii (gjzkmabrcd ) | |||||||
Not Applicable | 52 | uqflbcwood(jietgieoyu) = Adverse events were reported in >90% of cases, the most common being nausea and vomiting fmpatfiuhd (zpscbjcirz ) | - | 01 Jul 2014 | |||
Phase 3 | 944 | iqfqfrxabu(pnutgffmvs) = Nausea and vomiting occurred significantly more often after tigecycline treatment nepudhened (qqngdpslof ) View more | Negative | 01 Apr 2014 | |||
Ertapenem ± vancomycin | |||||||
Phase 4 | 12 | (Obese class III adults) | vfcttzimxp(dbcjihnerd) = qvptojctsn pedanagarf (cwrnchpthw ) View more | - | 01 Jan 2014 | ||
(Normal weight adults) | vfcttzimxp(dbcjihnerd) = wtobniqtwz pedanagarf (cwrnchpthw ) View more | ||||||
Phase 1 | - | - | bylrpcaxaw(xlfxbymbad) = tccqnafkwe nwvxatlcvk (wxcvxrxuol ) | - | 01 Jan 2014 |