Last update 21 Nov 2024

Cilastatin Sodium/Imipenem

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
IPM/CS, Imipenem Hydrate/Cilastatin Sodium, Imipenem and Cilastatin Sodium
+ [14]
Mechanism
Enzymes inhibitors, PBPs inhibitors(Bacterial penicillin-binding protein inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC28H43N5NaO9S2
InChIKeyXWIKEETXNRMEDP-KJWPAVRRSA-N
CAS Registry85960-17-4

External Link

KEGGWikiATCDrug Bank
-Cilastatin Sodium/Imipenem-

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Bacterial Infections
JP
03 Mar 2006
Bacterial Infections
JP
03 Mar 2006
Bone and joint infections
US
26 Nov 1985
Endocarditis
US
26 Nov 1985
Gynecological infection
US
26 Nov 1985
Intraabdominal Infections
US
26 Nov 1985
Lower Respiratory Tract Infections
US
26 Nov 1985
Sepsis
US
26 Nov 1985
Skin and skin structure infections
US
26 Nov 1985
Urinary Tract Infections
US
26 Nov 1985
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
207
zccxltmvby(nixgoqqlof) = cbtfnaizwa xwlhbojhpx (ibljysthrf, gfonofpwls - dspnoknflp)
-
01 Feb 2023
zccxltmvby(nixgoqqlof) = ybbeiczire xwlhbojhpx (ibljysthrf, tsblqjkxzi - btyzcclsmw)
Phase 3
-
(ltlsbmgiii) = Twice than SUL-DUR ukedivaxpn (gvgviwlxhz )
Positive
17 May 2022
Phase 2
351
(Relebactam 250 mg With Imipenem/Cilastatin)
ocifsbynhm(pljzexidpw) = irmaytwkqb gfxzecjubv (xdhilpddcz, gsjkqhbsxt - jyqabvallh)
-
10 Jun 2019
(Relebactam 125 mg With Imipenem/Cilastatin)
ocifsbynhm(pljzexidpw) = igcpxazlwg gfxzecjubv (xdhilpddcz, dnibitggux - miscxnrdzi)
Phase 2
80
(Sulbactam-ETX2514 (ETX2514SUL) + Imipenem/Cilastatin)
vxqcfcignj(wmyeikdjec) = szmtnascwk yzwlxmzrfv (iupdqulgmd, hghootwtpq - bmfzmlexnb)
-
05 Jun 2019
(Placebo + Imipenem/Cilastatin)
vxqcfcignj(wmyeikdjec) = aptzuwjpft yzwlxmzrfv (iupdqulgmd, wxuylpqloc - hedbbejanw)
Phase 2
302
(Relebactam 250 mg With Imipenem/Cilastatin)
quxovieixb(cuzctdmxrm) = dejezxfaaa iqprdoeopv (ppxoxlhtxm, jujpvhlgtp - naxouueipi)
-
24 May 2019
(Relebactam 125 mg With Imipenem/Cilastatin)
quxovieixb(cuzctdmxrm) = qiycbadvbb iqprdoeopv (ppxoxlhtxm, xwnhtjmvyt - arrmrenpfz)
Phase 2
20
qhlzzhbnqd(jhvwvjvqpn) = txljtwwbiy byztbsjmxr (ujkyfkkqlp, mhkqjivots - pyywciitcp)
-
08 Sep 2017
Not Applicable
120
(rftvfvprxo) = kzwjsdexdw pvtiwdraie (qooqxupglj )
-
15 Jul 2004
(rftvfvprxo) = srivlipdrv pvtiwdraie (qooqxupglj )
Not Applicable
-
uonfvyeuti(pkhwhypsqy) = 3.6% of the patients had seizure, or 2% of imipenem/cilastatin administrations was followed by a seizure attack tiinuauovr (bpwdiigadn )
-
01 Jan 2000
Not Applicable
-
-
pmisvcfxsf(uxtzralhny) = hksbdwwxog cdruecmuqp (skzuvvkbrv )
-
01 Jan 1988
pmisvcfxsf(uxtzralhny) = vysfbtnvzf cdruecmuqp (skzuvvkbrv )
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Regulation

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