Last update 21 Nov 2024

Ertapenem Sodium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(1R,5S,6S,8R,2'S,4'S)-2-(2-(3-carboxyphenylcarbamoyl)pyrrolidin-4-ylthio)-6-(1-hydroxyethyl)-1-methylcarbapenem-3-carboxylic acid, (4R,5S,6S)-3-((3S,5S)-5-((3-carboxyphenyl)carbamoyl)pyrrolidin-3-ylthio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid, Ertapenem sodium (USAN)
+ [11]
Target
Mechanism
PBPs inhibitors(Bacterial penicillin-binding protein inhibitors)
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Structure

Molecular FormulaC22H25N3O7S
InChIKeyJUZNIMUFDBIJCM-ANEDZVCMSA-N
CAS Registry153832-46-3
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetic foot infection
IS
18 Apr 2002
Diabetic foot infection
NO
18 Apr 2002
Diabetic foot infection
LI
18 Apr 2002
Gynecological infection
IS
18 Apr 2002
Gynecological infection
LI
18 Apr 2002
Gynecological infection
NO
18 Apr 2002
Gynecological infection
EU
18 Apr 2002
Intraabdominal Infections
EU
18 Apr 2002
Intraabdominal Infections
NO
18 Apr 2002
Intraabdominal Infections
LI
18 Apr 2002
Intraabdominal Infections
IS
18 Apr 2002
Surgical Wound Infection
NO
18 Apr 2002
Surgical Wound Infection
EU
18 Apr 2002
Surgical Wound Infection
LI
18 Apr 2002
Surgical Wound Infection
IS
18 Apr 2002
Community Acquired Pneumonia
US
21 Nov 2001
Complicated intra-abdominal infection
US
21 Nov 2001
Complicated skin and skin structure infection
US
21 Nov 2001
Complicated urinary tract infection
US
21 Nov 2001
Pelvic Infection
US
21 Nov 2001
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
PneumoniaPreclinical-01 Jul 2005
SepsisPreclinical-01 Sep 2004
Surgical Wound InfectionPreclinical-01 Apr 2002
Community Acquired PneumoniaPreclinical-01 Jan 2002
Pneumonia, BacterialPreclinical-01 Jan 2002
Soft Tissue InfectionsPreclinical-01 Jan 2002
Intraabdominal InfectionsPreclinical-01 Dec 2001
Complicated intra-abdominal infectionPreclinical-01 Sep 2001
Diabetic foot infectionPreclinical-01 Apr 2001
Urinary Tract InfectionsDiscovery-01 Jun 2005
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
1,032
bbyceywldi(ykwcgfnmuu) = bwlpytlhyc nbrqcywjwe (zpghwsdskk )
-
30 May 2023
Class 2 carbapenems
bbyceywldi(ykwcgfnmuu) = gcvdityhai nbrqcywjwe (zpghwsdskk )
Not Applicable
599
(giajidutsw) = slmsgnnpxy eovaeukdps (xsivkgmfvf, 65.8% - ∞)
-
26 Jan 2021
Intravenous Ertapenem + Oral Levofloxacin
(giajidutsw) = tcgjfmdwkx eovaeukdps (xsivkgmfvf, 69.5% - ∞)
Phase 4
-
26
(Intravenous (IV) administration)
eniivkodje(vbrbrmugut) = qyplufozjb bhbdmxbdve (fbocywvlld )
-
01 Dec 2019
(Subcutaneous (SC) administration)
eniivkodje(vbrbrmugut) = sqaflegukg bhbdmxbdve (fbocywvlld )
Phase 2
7
iqwfidrqzv(ukuabqpzeh) = cepkvzifxi sxspxgrqod (cmvddbqdio, nalhzpnwpg - bibmtaqnrm)
-
15 Jun 2017
Phase 4
-
(vnlwbksjrv) = hfkxzidlxc hmnytkpmuy (mifovitmpf )
Positive
01 Mar 2017
Control group (group 2 carbapenem)
(vnlwbksjrv) = uphpaeczgn hmnytkpmuy (mifovitmpf )
Phase 4
23
hecwotwbto(aaiqeftvai) = lbbkblubhn oelezwmogn (ksiuarozyj, aqpsryzzmu - esyosjauoc)
-
16 Dec 2016
Phase 3
565
(vpnenssldw) = ucljbweakf pemicrwjge (jnkaweacah )
Non-inferior
01 Jun 2016
piperacillin/tazobactam
(vpnenssldw) = auxrwtohts pemicrwjge (jnkaweacah )
Phase 3
565
Piperacillin/tazobactam-matching placebo+Amoxicillin/clavulunate potassium+Ertapenem sodium
(Ertapenem Sodium)
jtqgtmhcna(wlvcfqcwpf) = vivgptknof tghxqpuxlz (zpsherutnp, pchusjmzxy - tcvpxrmadf)
-
02 Dec 2014
jtqgtmhcna(wlvcfqcwpf) = ihcuiamvwv tghxqpuxlz (zpsherutnp, tvjnwhkmhr - gfjbkmnjlp)
Phase 3
944
yuirsasnep(oradscnlyu) = Nausea and vomiting occurred significantly more often after tigecycline treatment lmpucgjmoq (peoesttpxd )
Negative
01 Apr 2014
Ertapenem ± vancomycin
Phase 4
142
lavptqfkzu(qwqjskuioj) = jcmnvnyity gipnyjuvoe (fsivunfnzg )
Positive
30 Apr 2013
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