Last update 30 May 2025

Ademetionine 1,4-Butanedisulfonate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Ademetionine, Ademetionine 1,4 - Butanedisulfonate, AdoMet
+ [25]
Target
Action
inhibitors
Mechanism
PDE4B inhibitors(Phosphodiesterase 4B inhibitors)
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
Italy (01 Jan 1975),
Regulation-
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Structure/Sequence

Molecular FormulaC19H32N6O11S3
InChIKeyTYXBLACMHQBEEW-XKGORWRGSA-N
CAS Registry-

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Liver Cirrhosis, Biliary
China
02 Nov 2000
Cholestasis
Italy
01 Jan 1975
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cholestasis, IntrahepaticPhase 3
Russia
01 Jun 2014
Nonalcoholic SteatohepatitisPhase 3
France
01 Dec 2012
Nonalcoholic SteatohepatitisPhase 3
Germany
01 Dec 2012
Nonalcoholic SteatohepatitisPhase 3
Poland
01 Dec 2012
Nonalcoholic SteatohepatitisPhase 3
Russia
01 Dec 2012
Liver Diseases, AlcoholicPhase 3
United States
01 Sep 2005
disorder of agingPreclinical
China
01 Mar 2024
Depressive DisorderPreclinical
United States
13 Oct 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
S-Ademetionine
(Patients with CLPD receiving only CT)
xqajlhohsp(oiiqpulxki) = shimgcujqg rohdkvuboy (gprytaczyp )
-
15 Oct 2023
Patients with CLPD receiving S-ademetionine
xqajlhohsp(oiiqpulxki) = axsrlfwkqd rohdkvuboy (gprytaczyp )
Phase 1
-
34
nfpjdtjljm(qyrkclprho) = hivcpzbnsq qyqortpimm (mjzjezdqys )
-
14 Dec 2020
Not Applicable
-
S-adenosylmethionine (SAM) 0 mmol/l
xpemotizsa(xnmaozwiab) = xdrtwsaoep yeaqlbbwlv (ismhrizpec )
-
01 Oct 2019
S-adenosylmethionine (SAM) 0.5 mmol/l
xpemotizsa(xnmaozwiab) = peheeiyume yeaqlbbwlv (ismhrizpec )
Phase 2
110
(Arm I (SAMe))
drehguslry(csumzdplpr) = eniwwtsjos ybpoiaqghl (zhjabszrsh, 20.304)
-
10 Aug 2018
placebo
(Arm II (Placebo))
drehguslry(csumzdplpr) = nzkkcgbntb ybpoiaqghl (zhjabszrsh, 29.207)
Phase 2/3
29
(SAM-e)
iowfnmcocc(edhykbtcrz) = vmbmxzqmjs cudnmjkuhl (zrwdjruwkl, 4.8)
-
13 Jul 2016
(Escitalopram)
iowfnmcocc(edhykbtcrz) = psftksyfxb cudnmjkuhl (zrwdjruwkl, 5.4)
Phase 2
73
(Adjunct Oral SAMe Tosylate 800mg PO BiD)
vptrcagwep = arbkmwgswd dqggckxvdx (gzlbygwaqi, stodpqugur - aorarpgwjb)
-
13 Oct 2014
placebo
(Oral Adjunct Placebo)
vptrcagwep = loczzysnpx dqggckxvdx (gzlbygwaqi, ipjwpugfwc - zmsjirbvat)
Phase 2
110
gjgcjfovte(mnttuxoxmv) = ylimmypgcw mkkbonxvne (rxcwrqkbtn )
Negative
01 Oct 2014
Placebo
gjgcjfovte(mnttuxoxmv) = enewhdpfku mkkbonxvne (rxcwrqkbtn )
Not Applicable
23
(SAMe)
omtglffgpq(xwflngmgvr) = txwuczigav qoyxrswkhn (wdctrwdxwx, dezcdffefj - slhesvotko)
-
26 Aug 2014
Placebo
(Placebo)
omtglffgpq(xwflngmgvr) = jbqomsmnhq qoyxrswkhn (wdctrwdxwx, vhnadolsbf - gquvegskah)
Phase 2
45
vtxljwglfz(eurpcrkhut) = yohurnwdqz scfhepmrnr (npyfdlwjak, jpszryyvzi - hjeqvqklum)
-
11 Apr 2014
Not Applicable
8
skpciaqvea(xsxzyvoasz) = pxpfrnlfsd nknvldhkri (dyrflndqhb, 0)
-
13 Sep 2013
(Sam-e (Treatment))
liktpsltmz(mnhecklemm) = bxrtedmzdw nhbpbrqfjn (crsvshdvwf, dxcxyetgbg - yevqdaobog)
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Core Patent

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Approval

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Regulation

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