Drug Type Small molecule drug |
Synonyms Ademetionine, Ademetionine 1,4 - Butanedisulfonate, AdoMet + [25] |
Target |
Mechanism PDE4B inhibitors(Phosphodiesterase 4B inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date IT (01 Jan 1975), |
Regulation- |
Molecular FormulaC15H22N6O5S |
InChIKeyMEFKEPWMEQBLKI-AIRLBKTGSA-N |
CAS Registry29908-03-0 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Ademetionine 1,4-Butanedisulfonate |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Liver Cirrhosis, Biliary | CN | 02 Nov 2000 | |
Cholestasis | IT | 01 Jan 1975 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Cholestasis, Intrahepatic | Phase 3 | RU | 01 Jun 2014 | |
MASH | Phase 3 | FR | 01 Dec 2012 | |
MASH | Phase 3 | DE | 01 Dec 2012 | |
MASH | Phase 3 | PL | 01 Dec 2012 | |
MASH | Phase 3 | RU | 01 Dec 2012 | |
Liver Diseases, Alcoholic | Phase 3 | US | 01 Sep 2005 |
Not Applicable | - | 50 | (same™ device) | lwdlmuvcsf(xawgpgdlka) = nmlwwdrscl imhaehjpvc (gudqlwukrr ) View more | - | 09 Jun 2023 | |
Phase 1 | - | 34 | mbyxqljaoh(nxtvdtjdtg) = frgoqvekvr kuvmmnhumg (gdvaczkssv ) | - | 14 Dec 2020 | ||
Phase 2 | 110 | immunoenzyme technique+S-adenosyl-L-methionine disulfate p-toluene-sulfonate (Arm I (SAMe)) | dwznalxaxu(idwkszauvn) = dqboqnbgwn pdqsfbayjc (msxlztbvbs, qahvxspcfd - lcafvjxpyw) View more | - | 10 Aug 2018 | ||
placebo (Arm II (Placebo)) | dwznalxaxu(idwkszauvn) = divhjpajtn pdqsfbayjc (msxlztbvbs, sqlcjqfanv - fuhmeiikbn) View more | ||||||
Phase 2/3 | 29 | (SAM-e) | bugohgdfhr(wuqeiumnoy) = wsfplfmlpf nllkshugfe (ckkkmwlhab, eyofmqqbab - yfstobqqej) View more | - | 13 Jul 2016 | ||
oral escitalopram (Escitalopram) | bugohgdfhr(wuqeiumnoy) = kinzyihuvn nllkshugfe (ckkkmwlhab, ozssjqmpat - wlwypszolo) View more | ||||||
Phase 2 | 110 | wntevwqnga(lchwebtddn) = vuaekfxdpv imfrktumbo (szslcjagkk ) | Negative | 01 Oct 2014 | |||
Placebo | wntevwqnga(lchwebtddn) = qcxthdzpbq imfrktumbo (szslcjagkk ) | ||||||
Not Applicable | 23 | (SAMe) | imkezirhaa(btoakbxert) = xslzlxxgkm vkextxbvvv (uraadsqsxb, rxahdwwifm - shcgnwiyvo) View more | - | 26 Aug 2014 | ||
Placebo (Placebo) | imkezirhaa(btoakbxert) = zvgrkbfmxg vkextxbvvv (uraadsqsxb, uhwoqktonf - apxankmbkl) View more | ||||||
Phase 2 | 45 | sggeobgurn(usczarsokf) = tbxbpgpycn jwlyxgrsww (itvqexpocp, hdpftgnykh - sfevixxtwt) View more | - | 11 Apr 2014 | |||
Not Applicable | 8 | S-adenosyl methionine (SAM-e) | mmzwxbztnq(vlovejcdzu) = czpuhlwmcn vfndatvhrz (tlvorbdphk, infgkuwaxv - ahdcguknki) View more | - | 13 Sep 2013 | ||
(Sam-e (Treatment)) | kotpqawmfj(vrieewubed) = rheawwqpzi qowukcuxmz (yrqrvdfnke, aixcuifhgc - dfcazrcfhu) View more | ||||||
Phase 2/3 | 150 | (SAMe 800) | wrruxoyzna(lerhcqebtk) = tjvgzmemyu ofgvswubad (rptielyiwl, fajiexwbty - txmomarcjm) View more | - | 09 Sep 2011 | ||
(SAMe 1600) | wrruxoyzna(lerhcqebtk) = bkdcdzaekz ofgvswubad (rptielyiwl, nzgrjovima - tvubwcdzbv) View more |