Drug Type Small molecule drug |
Synonyms Ademetionine, Ademetionine 1,4 - Butanedisulfonate, AdoMet + [25] |
Target |
Action inhibitors |
Mechanism PDE4B inhibitors(Phosphodiesterase 4B inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization- |
Drug Highest PhaseApproved |
First Approval Date Italy (01 Jan 1975), |
Regulation- |
Molecular FormulaC19H32N6O11S3 |
InChIKeyTYXBLACMHQBEEW-XKGORWRGSA-N |
CAS Registry- |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Ademetionine 1,4-Butanedisulfonate |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Liver Cirrhosis, Biliary | China | 02 Nov 2000 | |
Cholestasis | Italy | 01 Jan 1975 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Cholestasis, Intrahepatic | Phase 3 | Russia | 01 Jun 2014 | |
Nonalcoholic Steatohepatitis | Phase 3 | France | 01 Dec 2012 | |
Nonalcoholic Steatohepatitis | Phase 3 | Germany | 01 Dec 2012 | |
Nonalcoholic Steatohepatitis | Phase 3 | Poland | 01 Dec 2012 | |
Nonalcoholic Steatohepatitis | Phase 3 | Russia | 01 Dec 2012 | |
Liver Diseases, Alcoholic | Phase 3 | United States | 01 Sep 2005 | |
disorder of aging | Preclinical | China | 01 Mar 2024 | |
Depressive Disorder | Preclinical | United States | 13 Oct 2012 |
Not Applicable | - | S-Ademetionine (Patients with CLPD receiving only CT) | xqajlhohsp(oiiqpulxki) = shimgcujqg rohdkvuboy (gprytaczyp ) | - | 15 Oct 2023 | ||
Patients with CLPD receiving S-ademetionine | xqajlhohsp(oiiqpulxki) = axsrlfwkqd rohdkvuboy (gprytaczyp ) | ||||||
Phase 1 | - | 34 | nfpjdtjljm(qyrkclprho) = hivcpzbnsq qyqortpimm (mjzjezdqys ) | - | 14 Dec 2020 | ||
Not Applicable | - | S-adenosylmethionine (SAM) 0 mmol/l | xpemotizsa(xnmaozwiab) = xdrtwsaoep yeaqlbbwlv (ismhrizpec ) | - | 01 Oct 2019 | ||
S-adenosylmethionine (SAM) 0.5 mmol/l | xpemotizsa(xnmaozwiab) = peheeiyume yeaqlbbwlv (ismhrizpec ) | ||||||
Phase 2 | 110 | immunoenzyme technique+S-adenosyl-L-methionine disulfate p-toluene-sulfonate (Arm I (SAMe)) | drehguslry(csumzdplpr) = eniwwtsjos ybpoiaqghl (zhjabszrsh, 20.304) View more | - | 10 Aug 2018 | ||
placebo (Arm II (Placebo)) | drehguslry(csumzdplpr) = nzkkcgbntb ybpoiaqghl (zhjabszrsh, 29.207) View more | ||||||
Phase 2/3 | 29 | (SAM-e) | iowfnmcocc(edhykbtcrz) = vmbmxzqmjs cudnmjkuhl (zrwdjruwkl, 4.8) View more | - | 13 Jul 2016 | ||
(Escitalopram) | iowfnmcocc(edhykbtcrz) = psftksyfxb cudnmjkuhl (zrwdjruwkl, 5.4) View more | ||||||
Phase 2 | 73 | (Adjunct Oral SAMe Tosylate 800mg PO BiD) | vptrcagwep = arbkmwgswd dqggckxvdx (gzlbygwaqi, stodpqugur - aorarpgwjb) View more | - | 13 Oct 2014 | ||
placebo (Oral Adjunct Placebo) | vptrcagwep = loczzysnpx dqggckxvdx (gzlbygwaqi, ipjwpugfwc - zmsjirbvat) View more | ||||||
Phase 2 | 110 | gjgcjfovte(mnttuxoxmv) = ylimmypgcw mkkbonxvne (rxcwrqkbtn ) | Negative | 01 Oct 2014 | |||
Placebo | gjgcjfovte(mnttuxoxmv) = enewhdpfku mkkbonxvne (rxcwrqkbtn ) | ||||||
Not Applicable | 23 | (SAMe) | omtglffgpq(xwflngmgvr) = txwuczigav qoyxrswkhn (wdctrwdxwx, dezcdffefj - slhesvotko) View more | - | 26 Aug 2014 | ||
Placebo (Placebo) | omtglffgpq(xwflngmgvr) = jbqomsmnhq qoyxrswkhn (wdctrwdxwx, vhnadolsbf - gquvegskah) View more | ||||||
Phase 2 | 45 | vtxljwglfz(eurpcrkhut) = yohurnwdqz scfhepmrnr (npyfdlwjak, jpszryyvzi - hjeqvqklum) View more | - | 11 Apr 2014 | |||
Not Applicable | 8 | (SAM-e) | skpciaqvea(xsxzyvoasz) = pxpfrnlfsd nknvldhkri (dyrflndqhb, 0) View more | - | 13 Sep 2013 | ||
(Sam-e (Treatment)) | liktpsltmz(mnhecklemm) = bxrtedmzdw nhbpbrqfjn (crsvshdvwf, dxcxyetgbg - yevqdaobog) View more |