A multicenter double blind, placebo-controlled randomized pilot study evaluating efficacy and safety of ETN in patients with moderate to severe plaque psoriasis after cessation of ciclosporin therapy

Start Date13 Sep 2007

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100 Clinical Results associated with Erythrityl Tetranitrate

100 Translational Medicine associated with Erythrityl Tetranitrate

100 Patents (Medical) associated with Erythrityl Tetranitrate

244

Literatures (Medical) associated with Erythrityl Tetranitrate

01 Feb 2025·Food Chemistry

Season-dependent variation in the contents of glucosinolates and S-methyl-l-cysteine sulfoxide and their hydrolysis in Brassica oleracea

Article

Author: Rohn, Sascha ; Hanschen, Franziska Sabine ; Witzel, Katja ; Púčiková, Vanda

Brassica vegetables contain glucosinolates and S-methyl-l-cysteine sulfoxide, which can be enzymatically hydrolyzed to form bioactive compounds. Glucosinolate hydrolysis can result in formation of health-promoting isothiocyanates, however, often less desirable nitriles and epithionitriles are formed due to presence of specifier proteins. Also, S-methyl-l-cysteine sulfoxide yields beneficial volatile organosulfur compounds (VOSC), such as S-methyl methanethiosulfinate. To optimize the nutritional value of Brassica oleracea vegetables, the outcome of these hydrolysis pathways was monitored over the harvest seasons of different cultivars in three consecutive years. Strong seasonal shifts in glucosinolate hydrolysis were observed only in red cabbages. They formed up to 40-fold more isothiocyanates in summer than in autumn, when nitriles and epithionitriles increased due to the induction of epithiospecifier proteins. Further, higher VOSC levels were found in autumn red cabbage. By elucidating the impact of abiotic growth factors on the regulation of the hydrolyses, the health value of Brassica vegetables can be improved.

01 Jan 2025·Propellants, Explosives, Pyrotechnics

Combined Solid‐Phase Extraction of Organic, Organic Peroxide, and Inorganic Explosives for Post‐Blast Residue Analysis

Author: Thomas, Jennifer L. ; Cruse, Courtney A. ; Fowble, Kristen L. ; Tipple, Christopher A. ; Miller, Jason V. ; Sipe, Sarah N. ; Borchers, Amara E. ; Pavone, David C. ; Armas, Stephanie ; Miller, Mark L. ; Mulder, Haley A.

ABSTRACTPost‐blast explosives residue may contain organic and/or inorganic explosives. Current methods employed involve splitting the sample swab in two for syringe extraction for each explosive type (acetone for organics, water for inorganics). A comprehensive solid‐phase extraction (SPE) trace sample clean‐up procedure for the combined recovery of 12 organic, 2 organic peroxide, and 15 inorganic analytes from explosives residue on cotton swabs is demonstrated and validated. By keeping the sample whole and using a single extraction process, the proposed method saves time, provides a more representative sample, and increases the possibility of detecting explosives that might be present on collection swabs. Thus, recoveries are improved for one class of explosives without sacrificing recoveries of another analyte or explosives class in the process. Extractions were demonstrated by syringe filtration and SPE from cotton balls (CBs) and cotton‐tipped applicators (CAs). For SPE of both matrices, organic explosives (nitramines, nitrate esters, nitroalkanes, and nitroaromatics) had a limit of detection (LOD) of 500 ppb or lower, organic peroxides had higher LODs at 5 ppm or lower, and most inorganic anions and cations had LODs at 1 ppm or lower. Application to 32 post‐blast samples, 9 burned powders simulating post‐blast, and 1 pre‐blast sample successfully demonstrated the SPE method with both cotton matrices in a comparison study of the two extraction procedures. SPE resulted in a lower false screen rate (number of compounds that met the screening criteria, but not confirmed present) when compared to syringe extraction.

01 Jan 2025·Propellants, Explosives, Pyrotechnics

Confirmation of Solid Phase Extracted Post‐Blast Explosives Residues Analyzed Using Pulsed Split Injection GC/MS

Author: Cruse, Courtney A. ; Miller, Mark L. ; Tipple, Christopher A.

AbstractA pulsed split injection method was developed for the improved detection of explosives using gas chromatography with mass spectrometric detection (GC/MS) with negative chemical ionization for 12 organic explosives (nitramines, nitrate esters, nitroalkanes, nitroaromatics) and electron ionization with selected ion monitoring for triacetone triperoxide (TATP). An order of magnitude increase in signal (average factor of 13) was observed for all organic explosives with the utilization of the pulsed split injection for samples processed by solid phase extraction (SPE). The method was successfully applied to post‐blast explosives residue processed by SPE and syringe filtration as a confirmatory technique following gas chromatography with electron capture detection (GC/ECD) screening. Compared to current methodologies previously reported, a decrease in the false screen rate (the number of compounds that passed the screening criteria, but not confirmed present) was achieved when employing this method. Processing of post‐blast explosives samples using SPE decreased the false screen rate from 60% to 34%, while using syringe filtration decreased the false screen rate from 73% to 51%.

100 Deals associated with Erythrityl Tetranitrate

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D04051	Erythrityl Tetranitrate	C01DA13	DB01613

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Indication	Country/Location	Organization	Date
Angina Pectoris	-	-	-
Coronary Artery Disease	-	-	-

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


equira study (EULAR2018)	Phase 3	Rheumatoid Arthritis	-	GP2015	(kvqnkhdtlp) = qwyduwygwq uwxjjohijy (ngybsrkvjy ) View more	-	13 Jun 2018
				ETN	(kvqnkhdtlp) = xkbpoycfiv uwxjjohijy (ngybsrkvjy ) View more
EULAR2017	Phase 3	Rheumatoid Arthritis anti-drug antibody (ADA) \| injection site reaction (ISR)	-	SB4	(bokrpacidk) = ykbhaopnpu kooprfexpu (bdzroilwjn ) View more	Positive	14 Jun 2017
				ETN	(bokrpacidk) = bqegmnddvz kooprfexpu (bdzroilwjn ) View more
EULAR2016	Not Applicable	-	-	TNF + ADA	ropmrmxffi(dcmhwqevjf) = qwomjqqxki tmmpxpairv (tzbvgysqrw )	-	08 Jun 2016
				TNF + ETN	ropmrmxffi(dcmhwqevjf) = rwifibnbki tmmpxpairv (tzbvgysqrw )
EULAR2015	Phase 3	Rheumatoid Arthritis	596	SB4	(gmvvzbdjlv) = vwxpyhnyag fesemcgpth (ovqsotztan ) View more	Positive	10 Jun 2015
				ETN	(gmvvzbdjlv) = xkdwaommtt fesemcgpth (ovqsotztan ) View more
PRIZE study (EULAR2014)	Phase 1	Rheumatoid Arthritis	306	ETN+MTX combination therapy	xveqngacdr(lejwwarbww) = gbtowgsyvl gvmdezyumv (mbyymioibl, 66.1 - 92.7) View more	Positive	11 Jun 2014
EULAR2014	Not Applicable	Rheumatoid Arthritis	-	ETN+MTX combination therapy	jpawvsogdw(hmrqdeutav) = xjlbecsefw laheucglwp (wwwyczslew ) View more	-	11 Jun 2014
				Triple therapy (MTX+HCQ+SLZ)	jpawvsogdw(hmrqdeutav) = kdfrselnua laheucglwp (wwwyczslew ) View more
EULAR2009	Not Applicable	Rheumatoid Arthritis \| Pneumonia, Pneumocystis	-	ETN	lxowdcjfbh(fsopafirmg) = gitunyohmf iujfawylte (zuxbpjraey )	Positive	10 Jun 2009
EULAR2008	Not Applicable	Rheumatoid Arthritis	-	MTX	(hmstngrlvs) = cxctogxzcw jejyoewmog (tosdnuxpvg ) View more	-	11 Jun 2008
				ETN	qisskmhvuy(vcdyomgpmj) = yahkjkiomr uwypuvrogu (vtkknmsiju ) View more
EULAR2006	Phase 3	-	-	ETN plus NSAIDs	eizjmkkvbn(jkanoworff) = rpeaursqtt fgfniizchv (tocnjtmwpq )	-	21 Jun 2006
EULAR2005	Not Applicable	Rheumatoid Arthritis	-	Methotrexate (MTX)	(eotrdxjscg) = vfhlokdtoz teakiknobp (zpkfqjrifg ) View more	-	08 Jun 2005
				Etanercept (ETN)	(eotrdxjscg) = rgxtuvbhbs teakiknobp (zpkfqjrifg ) View more

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