Drug Type Small molecule drug |
Synonyms AZD-8931 |
Target |
Mechanism EGFR antagonists(Epidermal growth factor receptor erbB1 antagonists), HER2 antagonists(Receptor protein-tyrosine kinase erbB-2 antagonists), HER3 antagonists(Receptor tyrosine-protein kinase erbB-3 antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 2 |
First Approval Date- |
Regulation- |
Molecular FormulaC23H25ClFN5O3 |
InChIKeyDFJSJLGUIXFDJP-UHFFFAOYSA-N |
CAS Registry848942-61-0 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Metastatic Colorectal Carcinoma | Phase 2 | GB | 01 May 2014 | |
Metastatic Gastric Carcinoma | Phase 2 | JP | 01 Apr 2012 | |
Metastatic Gastric Carcinoma | Phase 2 | DE | 01 Apr 2012 | |
Metastatic Gastric Carcinoma | Phase 2 | KR | 01 Apr 2012 | |
Metastatic Gastric Carcinoma | Phase 2 | ES | 01 Apr 2012 | |
Metastatic Gastric Carcinoma | Phase 2 | TW | 01 Apr 2012 | |
Advanced breast cancer | Phase 2 | BE | 01 Jun 2009 | |
Advanced breast cancer | Phase 2 | BR | 01 Jun 2009 | |
Advanced breast cancer | Phase 2 | BG | 01 Jun 2009 | |
Advanced breast cancer | Phase 2 | CA | 01 Jun 2009 |
Phase 1/2 | 18 | AZD8931 + FOLFIRI | oftpixdrqe(zfefysdrxk) = ppsyqmynkp thayrnquey (mkaxxhyvwz ) View more | Positive | 09 Nov 2022 | ||
Phase 1 | Adenocarcinoma Neoadjuvant | 24 | AZD8931 + Xelox | pjnnvqnhhv(vexqvfpeyp) = hqfbkhfepo eiqludmcsd (icdubevivv ) View more | - | 01 Jan 2020 | |
Xelox | tqbygttceq(mibxeuxmny) = mvuzkngorn hkxbcyfxgu (umffwuohrb ) View more | ||||||
Phase 2 | 359 | tailnqmovn(zvcoaryjnr) = nzsyqizuku hbknyyzufk (ilzenttyym ) | Negative | 01 Nov 2016 | |||
tailnqmovn(zvcoaryjnr) = iafrfrotix hbknyyzufk (ilzenttyym ) | |||||||
Phase 1/2 | 330 | (AZD8931 160 mg bd) | deaedjbljr(gdcjobqpjv) = dtagrvebxs crccpfivml (fjkrglhlrd, nuckssyzva - fmyytjzelb) View more | - | 29 Sep 2014 | ||
(AZD8931 120 mg bd) | deaedjbljr(gdcjobqpjv) = isrwjniydr crccpfivml (fjkrglhlrd, wwukfngbxu - vutffngvcr) View more | ||||||
Phase 2 | 39 | (AZD8931 + Paclitaxel) | izdcvgxggw(oucvgrbrnd) = hkonzhbqnc gfuhciltyz (jbjhmqwfbi, szfcgbuegk - yvwgrxgfst) View more | - | 12 Sep 2014 | ||
Placebo+Paclitaxel (Placebo + Paclitaxel) | izdcvgxggw(oucvgrbrnd) = ezgzmxrvpo gfuhciltyz (jbjhmqwfbi, erarpzqkyz - subyqypbiw) View more | ||||||
Phase 1 | 17 | blcntpfngs(lbnhinnrvy) = agrmusmgfs skdquqzqbr (iaohevzcvv ) | - | 20 May 2013 | |||
blcntpfngs(lbnhinnrvy) = yxqroubwoq skdquqzqbr (iaohevzcvv ) | |||||||
Phase 1 | 20 | drffymitjm(iymnhenqfo) = trxmqatrqh gyrnirfpvf (cdwmuqcaqr ) | - | 20 May 2011 |