Drug Type Small molecule drug |
Synonyms 4-Hydroxytamoxifen, 4-Hydroxytamoxifen (afimoxifene) gel, 4-Hydroxytamoxifen Gel + [5] |
Target |
Action modulators |
Mechanism ERs modulators(Estrogen receptors modulators) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
License Organization- |
Drug Highest PhaseDiscontinuedPhase 3 |
First Approval Date- |
Regulation- |
Molecular FormulaC26H29NO2 |
InChIKeyTXUZVZSFRXZGTL-UHFFFAOYSA-N |
CAS Registry68392-35-8 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D06551 | Afimoxifene | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Breast Diseases | Phase 3 | United States | 21 Aug 2017 | |
Breast Diseases | Phase 3 | Germany | 21 Aug 2017 | |
Breast Diseases | Phase 3 | Spain | 21 Aug 2017 | |
Invasive Mammary Carcinoma | Phase 2 | United States | 17 Feb 2020 | |
Estrogen receptor positive breast cancer | Phase 2 | United States | 01 Dec 2009 | |
Noninfiltrating Intraductal Carcinoma | Phase 2 | United States | 01 Dec 2009 | |
Mastodynia | Phase 2 | - | 01 Mar 2003 |
Phase 2 | 100 | Placebo+4-OHT (Arm I (4-OHT Topical Gel, Placebo)) | vpmfcmvqxu(rcpaevfkig) = mibndnpyld irwkxdtwbn (nmwvahvtvl, fwabomgbvw - vjsczsaxse) View more | - | 18 Dec 2024 | ||
Placebo+Tamoxifen (Arm II (Placebo, Oral Tamoxifen)) | vpmfcmvqxu(rcpaevfkig) = eozltzunes irwkxdtwbn (nmwvahvtvl, zehbodmnrg - eryaluyeao) View more | ||||||
Phase 2 | 194 | (4-OHT Gel) | lvsjihlveg(krrpnnvztk) = rhhrmopeyy pkugfsaftn (ulnjxulbmk, 9.11) View more | - | 22 Feb 2024 | ||
Placebo (Placebo) | lvsjihlveg(krrpnnvztk) = muclqikzsm pkugfsaftn (ulnjxulbmk, 11.24) View more | ||||||
Phase 2 | Noninfiltrating Intraductal Carcinoma estrogen receptor positive | 107 | Tamoxifen 20 mg/day + Placebo gel | actauvduim(ouofacdmap) = tsdudxuxxx bmdznnoowv (uzvijjuvih ) | Negative | 01 Mar 2023 | |
4-OHT gel (2mg 4-OHT gel/breast, bilaterally) + Oral Placebo | actauvduim(ouofacdmap) = vizyggnlru bmdznnoowv (uzvijjuvih ) | ||||||
Phase 3 | 223 | (BHR-700 (0.2% 4-OHT Gel)) | xxexwrartl(kjrhimlszs) = ogcodcolwp gqlcndtoql (mrnnfngbbb, 1.6) View more | - | 17 Nov 2021 | ||
Placebo (Matching Placebo Gel) | xxexwrartl(kjrhimlszs) = bpbslsyzqg gqlcndtoql (mrnnfngbbb, 1.6) View more | ||||||
Phase 2 | 27 | Placebo (Treatment Gel + Oral Placebo) | wxcxeklzwb(izxviiluom) = derzxhbiob otnmdgcrnd (mlrvhgctxd, 5.0) View more | - | 21 Jul 2015 | ||
Placebo (Placebo Gel + Oral Treatment) | wxcxeklzwb(izxviiluom) = lhhdcksxta otnmdgcrnd (mlrvhgctxd, 5.5) View more | ||||||
Not Applicable | - | ydacnjrduv(ktdprabldx) = ilmbfqzqwk mzelncitlo (npfykiepyz ) | - | 20 May 2009 |