Last update 21 Nov 2024

Icotinib Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Conmana, Icotinib, 埃克替尼
+ [5]
Mechanism
EGFR antagonists(Epidermal growth factor receptor erbB1 antagonists), EGFR exon 21 L858R mutation inhibitors
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
CN (07 Jun 2011),
RegulationSpecial Review Project (CN), Priority Review (CN)
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Structure

Molecular FormulaC22H22ClN3O4
InChIKeyPNNGXMJMUUJHAV-UHFFFAOYSA-N
CAS Registry1204313-51-8
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Non-Small Cell Lung Cancer
CN
07 Jun 2011
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
EGFR-mutated non-small Cell Lung CancerPhase 3
CN
02 Jun 2015
Non-Small Cell Lung CancerPhase 3--
Lung Cancer with Brain MetastasisPhase 1
CN
20 Jul 2018
EGFR Mutation Lung CancerPhase 1
CN
01 Sep 2014
EGFR positive non-small cell lung cancerPhase 1
CN
01 Sep 2014
Non-small cell lung cancer stage IIIAPhase 1
CN
01 Apr 2013
Advanced Lung AdenocarcinomaPhase 1
CN
01 Dec 2012
EGFR positive Adenocarcinoma of LungPhase 1
CN
01 Dec 2012
Advanced Lung Non-Small Cell CarcinomaPhase 1
CN
01 Sep 2012
Gastroesophageal junction adenocarcinomaPreclinical
CN
01 May 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
NEWS
ManualManual
Phase 3
118
埃克替尼单药组
(heklivrsvg) = kdlqgcruvb rkigrjkxub (nbwafrqajg )
Positive
14 Oct 2024
埃克替尼联合TRT组
(heklivrsvg) = bssltybstx rkigrjkxub (nbwafrqajg )
Phase 2
133
Chemotherapy
(sigtzqwixz) = yvycpxprfw txjtoiqktk (bodmpepyoi )
Positive
09 Sep 2024
First-generation EGFR-TKIs
(sigtzqwixz) = kepqepxkly txjtoiqktk (bodmpepyoi )
Phase 3
251
Icotinib 12 months
(hjnslpyewn) = bggwvuffja pmnwlbwzzk (npmclsvzqi, 43.3 - 80.3)
Positive
24 May 2024
Icotinib 6 months
(hjnslpyewn) = dmaydnchrp pmnwlbwzzk (npmclsvzqi, 44.8 - 81.6)
WCLC2023
ManualManual
Phase 1/2
24
(laqonsddcw) = aumolertinib 110 mg po qd plus icotinib 125mg po tid gtqkulzhsu (pnazjpggcm )
Positive
11 Sep 2023
Phase 2
109
(lhafoekqsr) = eaztfoqmak fnnmjhwmhn (xwiihiwbdc, 26.6 - 44.8)
Positive
20 Jun 2023
(lhafoekqsr) = pprkltlmpj fnnmjhwmhn (xwiihiwbdc, 33.1 - 70.1)
Phase 2
128
(giciwxobny) = bmsayynlpt lhrgcldrjj (dcxixetupt, 91.3 - 99.9)
Positive
01 Mar 2023
(Observation)
(giciwxobny) = dihsdpdbry lhrgcldrjj (dcxixetupt, 75.1 - 92.9)
Not Applicable
105
(faoplbqfyb) = pyxsnymppt dljiywlmuv (lcirvmopwr )
-
03 Dec 2022
(faoplbqfyb) = zyxbfgokeq dljiywlmuv (lcirvmopwr )
Phase 2
10
scghtrumpw(gyojkiylac) = -23.58% and -22.01% aszwfmygzy (qcsdrihxiy )
Positive
21 Oct 2022
Not Applicable
40
(vcshvisgko) = uvbqgzduix kgbgbaeyjq (gdtxhhmnyj )
-
21 Sep 2022
Phase 2
116
(bmnnbkqsag) = hpihvrcyzm ndqazrkvbx (cwvfrkttaa, 43.1 - 61.9)
Positive
21 Jul 2022
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