Last update 27 Mar 2025

Oxybutynin Chloride

Overview

Basic Info

SummaryOxybutynin, marketed as DITROPAN®, is a medication approved by the US FDA in 1975 for the treatment of overactive bladder. Developed by Janssen, the drug works as an antagonist of acetylcholine at postganglionic muscarinic receptors, causing relaxation of the smooth muscle in the bladder. It is a racemic mixture of R- and S-isomers, with the antimuscarinic activity mainly residing in the Risomer. Additionally, the active metabolite, N-desethyloxybutynin, has similar pharmacological effects on human detrusor muscle as oxybutynin, as observed in in vitro studies. Overall, Oxybutynin Chloride offers relief to those experiencing urinary urgency, frequency, and incontinence.
Drug Type
Small molecule drug
Synonyms
Aroxybutynin, oxybutynin, Oxybutynin (USAN/INN)
+ [42]
Target
Action
antagonists
Mechanism
mAChRs antagonists(Muscarinic acetylcholine receptor antagonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (16 Jul 1975),
Regulation-
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Structure/Sequence

Molecular FormulaC22H32ClNO3
InChIKeySWIJYDAEGSIQPZ-UHFFFAOYSA-N
CAS Registry1508-65-2

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Hyperhidrosis Palmaris Et Plantaris
Japan
27 Mar 2013
Pollakisuria
Japan
29 Mar 1988
Urinary Incontinence
Japan
29 Mar 1988
Urinary urgency
Japan
29 Mar 1988
Spinal Dysraphism
United States
29 Nov 1979
Urinary Incontinence, Urge
United States
29 Nov 1979
Urinary Bladder, Overactive
United States
16 Jul 1975
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Lower Urinary Tract SymptomsPhase 3-01 May 2004
Urination DisordersPhase 3-01 May 2004
Diabetic peripheral neuropathyPreclinical
United States
01 Jun 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
20
qrkztrqtoe(vsujfgidgb) = tbfywtbeya onnyfndxyi (bazycjqcpd, jpdlpmwpsc - mbbzivwnxv)
-
03 Oct 2022
Not Applicable
15
5 mg of Oxybutynin and 6 mg of Reboxetine (oxy-reb)
jwdanvngma(cfrvfozrmr) = axcoeokdxv yaqzaocqbo (htscifvwtm, 22.7 - 52.3)
-
04 Sep 2022
Placebo
jwdanvngma(cfrvfozrmr) = pdzmmrdito yaqzaocqbo (htscifvwtm, 23.3 - 44.1)
Phase 2
-
30
xmzcuomags(ekkejckcxa) = umbgxrdpbw gviirmmlew (rauqckknrn )
Positive
11 Mar 2022
xmzcuomags(ekkejckcxa) = kffrgmrhtb gviirmmlew (rauqckknrn )
Phase 3
855
lcjajfiacy = gswgujlkwg hmaruoezmr (grnbetvoyv, tltlwpfowt - oktsnkpvtg)
-
20 Oct 2020
Phase 3
150
(High-dose Oxybutynin Chloride Group)
gkgbgacktx(bqbqxjndam) = sdlzvcqmit ggzpkaaxva (bugqtbcgat, 15.6)
-
03 Jun 2019
(Low-dose Oxybutynin Chloride Group)
gkgbgacktx(bqbqxjndam) = hozspfznak ggzpkaaxva (bugqtbcgat, 7.7)
Not Applicable
10
xqdpzuxhcd = goclluhxxe uqevcnqeji (pjnxeefpwq, lmbokqsdsi - amhrshelyd)
-
19 Jun 2018
Phase 4
55
Posterior Tibial Nerve Stimulation+Oxybutynin extended release
(Oxybutynin Plus PTNS)
lckoesrvip(hrsdferveq) = ncwuulixgj yqjcltrrrv (zroautkahy, ldjjjaobcl - cogvnnubfi)
-
23 Jan 2018
Posterior Tibial Nerve Stimulation
(Placebo Plus PTNS)
lckoesrvip(hrsdferveq) = walndnplag yqjcltrrrv (zroautkahy, ikfsnoqlcl - xkjcyrxont)
Phase 3
35
kgbzenlosf(ilsxhhnuzn) = The main side effect was skin irritation at TOP site (35%), leading to discontinuation in 20% okeqxbxpvt (krhnqnyyeb )
Positive
01 Aug 2014
Not Applicable
166
kmpiylnqja(iwcjfktzrn) = efupuobgfp lixpjougir (tnggfxbsck, 32.6)
-
19 Dec 2013
Phase 4
345
iyqswfnaow = qrbiyanrrc rxqowkoyky (cevxawsezi, gatjauzaoy - vqnmidxchm)
-
16 Sep 2013
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