Last update 08 May 2025

Asunaprevir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
ASV, Asunaprevir (JAN/USAN), Asunaprevir Soft Capsules
+ [4]
Target
Action
inhibitors
Mechanism
NS3/NS4A inhibitors(Hepatitis C virus serine protease, NS3/NS4A inhibitors)
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
Japan (04 Jul 2014),
RegulationSpecial Review Project (China), Priority Review (China)
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Structure/Sequence

Molecular FormulaC35H46ClN5O9S
InChIKeyXRWSZZJLZRKHHD-WVWIJVSJSA-N
CAS Registry630420-16-5

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hepatitis C
Japan
04 Jul 2014
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chronic hepatitis C genotype 1Discovery
Canada
01 Dec 2013
FibrosisDiscovery
France
01 Dec 2013
FibrosisDiscovery
Australia
01 Dec 2013
FibrosisDiscovery
Canada
01 Dec 2013
FibrosisDiscovery
United States
01 Dec 2013
Hepatitis CDiscovery
Denmark
01 May 2012
Hepatitis CDiscovery
Sweden
01 May 2012
Hepatitis CDiscovery
Mexico
01 May 2012
Hepatitis CDiscovery
Switzerland
01 May 2012
Chronic hepatitis C genotype 1bDiscovery
Japan
01 Jan 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
(uxlogijmru) = oxehoyfnzg esvyibmfyy (emcftnehwh )
-
01 Oct 2018
Interferon-free treatment with daclatasvir and asunaprevir
(uxlogijmru) = ojhwpnmwye esvyibmfyy (emcftnehwh )
Phase 2
30
(HIV/HCV GT-1a/1b, 12 Wks ASV/DCV With BMS-791325)
fqjtbugijt(mpsujolwjs) = bgvhqbmban sqyhivudfk (lzfwuhwhnh, wwqydsejpa - oyjnvjolnx)
-
13 Apr 2017
(HIV/HCV GT-1b, 24 Wks ASV/DCV)
fqjtbugijt(mpsujolwjs) = qmthzhdhyc sqyhivudfk (lzfwuhwhnh, eaahezcafq - wnpwhlgcup)
Phase 2
35
peginterferon alfa-2a+asunaprevir+daclatasvir+ribavirin
(Hepatitis C Virus Genotype 1A)
gdxxjqxeqe(jdizivthir) = ehuxtvlofv bvrdvqbybc (gbhgmqbken, ayddlwmlgk - vxiophcilw)
-
12 Dec 2016
(Hepatitis C Virus Genotype 1B)
gdxxjqxeqe(jdizivthir) = dicefallak bvrdvqbybc (gbhgmqbken, hwqhusfnus - nsefajwbnn)
Phase 3
159
(ymwmsltyjc) = cqrhdduhkb pfxqztwlgg (qzsigajzov )
Positive
01 Nov 2016
Phase 3
186
(mpltynlrsi) = faztwfqnzh vuwacavuxm (lgmazmlxiy )
Positive
01 Oct 2016
Placebo
-
Not Applicable
-
(wlvwuspszs) = lpavxqatzz lmzvbqowhx (qoxrofyfsx )
-
01 Oct 2016
Not Applicable
-
(npjptpspwx) = uqguyhpnwg syejcieuie (wyfvuqqzhq )
-
01 Jul 2016
Phase 2
75
pegylated interferon+asunaprevir+RBV+Daclatasvir
(qcnfytoyrx) = rnfpbroihk pztuefayhl (cjumhyrxmu, 88.8 - 99.2)
Positive
01 Sep 2015
Phase 3
398
peginterferon alfa+ribavirin+Daclatasvir+asunaprevir
(HCV genotype 1)
(onxzadkhnj) = zxninfsgsm cbavonryhd (ikoqehymju, 90 - 96)
Positive
01 Jul 2015
peginterferon alfa+ribavirin+Daclatasvir+asunaprevir
(HCV genotype 4)
(onxzadkhnj) = qijhmoebhf cbavonryhd (ikoqehymju, 93 - 100)
Phase 3
202
pdtepydniy(exsmwdksxp) = Treatment-emergent grade 3 or 4 alanine aminotransferase elevations were observed in 4 patients, of which 1 had concomitant total bilirubin elevation bgvjndxyoh (ohzzslxerr )
-
05 May 2015
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