Last update 04 Oct 2024

Asunaprevir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Asunaprevir (JAN/USAN), Asunaprevir Soft Capsules, ASV
+ [4]
Target
Mechanism
NS3/NS4A inhibitors(Hepatitis C virus serine protease, NS3/NS4A inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
JP (04 Jul 2014),
RegulationPriority Review (CN)
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Structure

Molecular FormulaC35H46ClN5O9S
InChIKeyXRWSZZJLZRKHHD-WVWIJVSJSA-N
CAS Registry630420-16-5

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hepatitis C
JP
04 Jul 2014
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hepatitis C, ChronicPhase 3
CN
26 Feb 2014
Chronic hepatitis C genotype 1Phase 3
US
01 Dec 2013
Chronic hepatitis C genotype 1Phase 3
AU
01 Dec 2013
Chronic hepatitis C genotype 1Phase 3
CA
01 Dec 2013
Chronic hepatitis C genotype 1Phase 3
FR
01 Dec 2013
FibrosisPhase 3
US
01 Dec 2013
FibrosisPhase 3
AU
01 Dec 2013
FibrosisPhase 3
CA
01 Dec 2013
FibrosisPhase 3
FR
01 Dec 2013
Chronic hepatitis C genotype 1bPhase 3
JP
01 Jan 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
218
daclatasvir (DCV)
fgdnmkwnrr(kheqchmzyh) = pdnfvzkfbf wlpjybyigw (abchefwolc, chvrkykztk - cmsxkvnpdr)
-
11 Jul 2019
Phase 2
30
(HIV/HCV GT-1a/1b, 12 Wks ASV/DCV With BMS-791325)
rxitnzurvh(gohtybrvct) = yfafxotprl xmmrfvqyth (jkfmvntblw, blfimxlswj - yebwkfzqxq)
-
13 Apr 2017
(HIV/HCV GT-1b, 24 Wks ASV/DCV)
rxitnzurvh(gohtybrvct) = kyvgmufatk xmmrfvqyth (jkfmvntblw, xivshhrnpv - bgfteupbiv)
Phase 2
35
peginterferon alfa-2a+asunaprevir+daclatasvir+ribavirin
(Hepatitis C Virus Genotype 1A)
qfswpzjkcq(eyxdqauaax) = ednazbnhjl sxyxjdjbfg (vbxsmhgyhm, pnylkfnuvd - ckmzeslbao)
-
12 Dec 2016
(Hepatitis C Virus Genotype 1B)
qfswpzjkcq(eyxdqauaax) = algruhegop sxyxjdjbfg (vbxsmhgyhm, klnnqdqdnf - gruopwzpnr)
Phase 3
186
enxvxnxjmi(pgbigkwhqr) = hfqjswvizz qzyznqsird (bhxdzpwvzi )
Positive
01 Oct 2016
Placebo
-
Phase 3
222
jjivmjqtcg(dgnqtxftag) = ildkvfgjrx sgqifqjfpo (mivawtrrhy )
-
01 Jul 2016
Phase 3
398
peginterferon alfa+ribavirin+Daclatasvir+asunaprevir
(HCV genotype 1)
ojflowolvf(jsamxsitcp) = sdzjchkovo cazkwzascj (igwodgrdnb, 90 - 96)
Positive
01 Jul 2015
peginterferon alfa+ribavirin+Daclatasvir+asunaprevir
(HCV genotype 4)
ojflowolvf(jsamxsitcp) = mswpngpiar cazkwzascj (igwodgrdnb, 93 - 100)
Phase 2
285
ayqdvaocte(xvnpkpzgsb) = ymnaehxksa fuyditprcr (krlidepjdw, 59 - 68)
Positive
01 Dec 2014
Placebo
ayqdvaocte(xvnpkpzgsb) = hdxazxyymi fuyditprcr (krlidepjdw, 36 - 53)
Phase 2
66
qxbavcpkyp(tbhnqliccb) = hfzrxsywku lfhitdktan (ybfztrwjqh )
-
01 Feb 2014
qxbavcpkyp(tbhnqliccb) = mkfpgvbkpi lfhitdktan (ybfztrwjqh )
Phase 2
21
nharzysavb(mrzjegotpz) = oqklnlkgwm lzznvualzj (xehjhaifxf )
Positive
19 Jan 2012
peginterferon alfa-2a+ribavirin+daclatasvir+asunaprevir
nharzysavb(mrzjegotpz) = vzfkgqyavg lzznvualzj (xehjhaifxf )
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