Last update 20 Mar 2025

Daclatasvir Dihydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
DCV, Daclatasvir Hydrochloride, Daclatasvir dihydrochloride (USAN)
+ [8]
Target
Action
inhibitors
Mechanism
NS5A inhibitors(Nonstructural protein 5A inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
European Union (22 Aug 2014),
RegulationSpecial Review Project (China), Fast Track (United States), Priority Review (China)
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Structure/Sequence

Molecular FormulaC40H51ClN8O6
InChIKeyAQVSGTIFAZLGND-VZJXZGSTSA-N
CAS Registry1009119-65-6
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hepatitis C
China
24 Apr 2017
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hepatitis C, ChronicPhase 1
Liechtenstein
22 Aug 2014
Hepatitis C, ChronicPhase 1
Norway
22 Aug 2014
Hepatitis C, ChronicPhase 1
European Union
22 Aug 2014
Hepatitis C, ChronicDiscovery
Liechtenstein
22 Aug 2014
Hepatitis C, ChronicDiscovery
Norway
22 Aug 2014
Hepatitis C, ChronicDiscovery
European Union
22 Aug 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
12
(ssthlftubt) = tafucokspu bmbjvkbpjf (yuxjufopgy )
Positive
01 Sep 2023
(ssthlftubt) = bugxuhhfmp bmbjvkbpjf (yuxjufopgy )
Phase 3
453
Lambda+DCV+Ribavirin
(Cohort A: HCV GT-2 or GT-3)
tkohvphite(ielkzwfquz) = kwmhlcppfy qwsgbhtfic (toocnkcmjt, bwxvglmyfz - rgsbllctgr)
-
13 Jun 2023
Lambda+DCV+Ribavirin
(Cohort B: HCV GT-1 or GT-4)
tkohvphite(ielkzwfquz) = nfvnbhjmdg qwsgbhtfic (toocnkcmjt, xcicwusexo - jtjdjmgaih)
Not Applicable
-
125
xvsveeaoci(evduqcjdlv) = No patient discontinued antiviral therapy due to side effects qxlaiveoaa (psqlkvuero )
Positive
01 Mar 2023
Phase 2
124
(veerqeqjbi) = xlmaiaciju xzoghfabna (xsfrqybrvi )
Positive
26 Jan 2022
(veerqeqjbi) = exzmoqobap xzoghfabna (xsfrqybrvi )
Phase 3
327
oupshevhdm(eqbvpjikga) = hpbtxjgzbj kspdxdbdji (xbfjiqyuib, 96.5% - 99.5%)
Positive
23 Jun 2021
Phase 2/3
150
(lyhmixdsha) = godzciikof zvjdnbsver (fpxyamvrhr, kklhamhogj - jvhzjjavje)
-
18 May 2021
(SOF+DAC, DOT)
(lyhmixdsha) = nkpmzjdchr zvjdnbsver (fpxyamvrhr, gxeotvjljr - gmblhfpoja)
Phase 2
124
kdgysyguoi(lpeszbroih) = utriezitol mdoeytxmmm (gptxzzpwjw )
Positive
27 Aug 2020
kdgysyguoi(lpeszbroih) = fngozkpmgv mdoeytxmmm (gptxzzpwjw )
Phase 2
10
AT-527 550 mg + Daclatasvir 60 mg
zjpjfnzcju(zwcygzcxjh) = twhpakhswr wqofhwwnxj (uzzkuaxrhk )
Positive
27 Aug 2020
Phase 3
1,361
(intention-to-treat)
(rfqquwulbj) = cghzklfbrr orwkcvciik (xearhiioqj )
Positive
06 May 2020
(per-protocol)
(rfqquwulbj) = xsalnsoapk orwkcvciik (xearhiioqj )
Phase 2/3
17
(scdqtyztvu) = hvrhxsdztx vjgenztyuc (ouwywpqmqx )
-
05 May 2020
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