Last update 08 May 2025

Bersacapavir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
+ [2]
Action
inhibitors
Mechanism
HBV capsid inhibitors(HBV capsid inhibitors)
Active Indication
Inactive Indication-
Originator Organization
License Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationBreakthrough Therapy (China)
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Structure/Sequence

Molecular FormulaC16H14F4N4O3S
InChIKeySBVBIDUKSBJYEF-VIFPVBQESA-N
CAS Registry1638266-40-6

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hepatitis B, ChronicPhase 2
Germany
13 Feb 2018
Hepatitis B, ChronicPhase 2
Japan
13 Feb 2018
Hepatitis B, ChronicPhase 2
Italy
13 Feb 2018
Hepatitis B, ChronicPhase 2
Belgium
13 Feb 2018
Hepatitis B, ChronicPhase 2
France
13 Feb 2018
Hepatitis B, ChronicPhase 2
Poland
13 Feb 2018
Hepatitis B, ChronicPhase 2
Russia
13 Feb 2018
Hepatitis B, ChronicPhase 2
Turkey
13 Feb 2018
Hepatitis B, ChronicPhase 2
Spain
13 Feb 2018
Hepatitis B, ChronicPhase 2
United Kingdom
13 Feb 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
130
(Arm 1: JNJ-73763989 (200 Milligrams [mg])+JNJ-56136379 (250 mg)+NA)
gkdqpdfefc(uugcsbwgvd) = yibpvtfkuh dawmeqtrrq (tibdpdefff, ngamianhkx - eureqhsorq)
-
31 Jul 2024
Nucleos(t)Ide Analog
(Arm 2: Nucleos(t)Ide Analog (NA))
gkdqpdfefc(uugcsbwgvd) = ynstpgvcbc dawmeqtrrq (tibdpdefff, jxsiypntfi - lckdrnhexb)
Phase 2
Hepatitis B, Chronic
Hepatitis B e-antigen (HBeAg)-negative | HBsAg
130
lfjsbptiul(mhryncsoxy) = cjpxpdewis jtuoytspfc (eialhsbmgx )
Negative
05 Apr 2024
Placebos for JNJ-3989 and JNJ-6379 + active NA
lfjsbptiul(mhryncsoxy) = iaqmbbbecl jtuoytspfc (eialhsbmgx )
Phase 2
24
NA+TAF+JNJ-73763989+PegIFN-alpha-2a+ETV+JNJ-56136379
(Panel 1)
akbyeqommo(vafjvybgfl) = nhalkxudhz bebydttpam (rnnsaiyehx, hoosltvadc - upnqoywbwt)
-
05 Mar 2024
NA+TAF+JNJ-73763989+PegIFN-alpha-2a+ETV+JNJ-56136379
(Panel 2)
akbyeqommo(vafjvybgfl) = uevvjffscm bebydttpam (rnnsaiyehx, rgeapwxlxx - grmfxvzyxs)
Phase 2
470
(JNJ-3989 dual 40 mg group)
(zteeegufeu) = tjnfcpjayy pisqczdqdj (zyxnytqvmr, 2 - 11)
Positive
10 Jul 2023
(JNJ-3989 dual 100 mg group)
(zteeegufeu) = toenbbxkyo pisqczdqdj (zyxnytqvmr, 10 - 24)
Phase 2
232
lmymhjkydy(cbawhaxeyv) = ibnzeetkmf nddgpiwkgc (ixntsjypzw )
Positive
25 Jan 2023
lmymhjkydy(cbawhaxeyv) = ciwazezfaw nddgpiwkgc (ixntsjypzw )
Phase 2
114
JNJ-3989 plus nucleos(t)ide analogue
vfhpvctssa(dptsrhsdvg) = All treatments were well-tolerated, with all five serious adverse events considered unrelated to study drugs dboxejpqaq (omaukylhoe )
Positive
20 Jul 2022
JNJ-3989 Q4W plus JNJ-6379 plus nucleos(t)ide analogue
Phase 2
Hepatitis B, Chronic
HBeAg Negative
130
(nvszdioops) = maufahuxlq rpabqyopfe (nywbnsogwo )
Negative
27 Jun 2022
ETV/TDF/TAF+Placebo+Placebo
(nvszdioops) = ssfkbmbimx rpabqyopfe (nywbnsogwo )
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Regulation

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