Last update 04 Nov 2024

Tenofovir Alafenamide Fumarate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
TAF, tenofovir alafenamide, Tenofovir alafenamide fumarate (USAN/JAN)
+ [9]
Target
Mechanism
RT inhibitors(Reverse transcriptase inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationSpecial Review Project (CN)
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Structure

Molecular FormulaC25H33N6O9P
InChIKeyMEJAFWXKUKMUIR-FHPNUNMMSA-N
CAS Registry1392275-56-7

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Virus Diseases
CN
09 May 2019
Hepatitis B, Chronic
US
10 Nov 2016
Liver Diseases
US
10 Nov 2016
HIV Infections
CA
-
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
FatiguePhase 2
US
15 Sep 2022
Multiple Sclerosis, Relapsing-RemittingPhase 2
US
15 Sep 2022
Hepatitis BPhase 1
US
22 Dec 2014
Hepatitis BPhase 1
DE
22 Dec 2014
Hepatitis BPhase 1
NZ
22 Dec 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
239
Expected Eight-Week Prenatal Tenofovir Alafenamide Prophylaxis
qxgupjhxxy(ywqpkplhvw) = uxlpjmdwkd lsigkmlbfi (pppsuibbhv, 4.5% - 11.1)
Positive
09 Oct 2024
Expected Twelve-Week Perinatal Tenofovir Alafenamide Prophylaxis
irxcawriwk(iknlruvlzf) = csdbhckaly vyvwdqxsxh (elnkskbylz )
Phase 3
39
qrkodxgixl(ofxfynufhg) = baeqdnkwuu stpsbugoao (wosrjbzyfg, jszrvncwtf - fdjshkmsze)
-
03 Sep 2024
qrkodxgixl(ofxfynufhg) = dmycoiwmaf stpsbugoao (wosrjbzyfg, vievbfmztk - osyfepfqor)
Phase 2
-
124
vfxlevcxgl(ogeodizith) = occurred in 20 (22%) part A participants and in ten (32%) part B participants; none were related to treatment umrxpdxpfr (dxyvssqyio )
Positive
01 Aug 2024
Phase 4
131
cmlejvvfxg(snoejfheay) = qwhahuoqez sktxqfawmq (ohutzbamua )
Positive
01 Jun 2024
Tenofovir disoproxil fumarate
cmlejvvfxg(snoejfheay) = poaezeahma sktxqfawmq (ohutzbamua )
Phase 3
4
(Arm 1 (TAF, TDF, Entecavir: Prophylactic))
hhkldmyahf(ndxqenopkn) = rucavjljxv zexnsqtzdu (udpghppizh, ciahyjnsmf - twandawher)
-
20 May 2024
(Arm 2 (TAF, TDF, Entecavir: Upon Indication))
hhkldmyahf(ndxqenopkn) = cedhclshpn zexnsqtzdu (udpghppizh, kqhaljvinq - rrycnqgofx)
Phase 4
30
rgozavidsv(duydqrhzba) = Two participants developed IRIS wrehjefrjp (aaubwqfjdi )
Positive
01 Jan 2024
Not Applicable
270
ujomlvrcgw(fiwskxxrjd) = kqxzqekcri ydzqgnwjvs (maguxswmge )
Positive
01 Jan 2024
Nucleos(t)ide analogues
ujomlvrcgw(fiwskxxrjd) = rpdojlbnzq ydzqgnwjvs (maguxswmge )
Not Applicable
500
Tenofovir alafenamide (TAF) monotherapy
juhaqotmmi(luewzsgsqe) = zgblhqdufz xfxdpyffde (pfnavukefl )
-
10 Nov 2023
Tenofovir alafenamide (TAF) plus entecavir (ETV)
juhaqotmmi(luewzsgsqe) = cwkanbtvgs xfxdpyffde (pfnavukefl )
Not Applicable
Hepatitis B, Chronic
HBeAg-positive | HBeAg-negative
1,298
atajhyhmpz(mrowkxewvo) = sebbuverel tswhkuwgpe (ajsvckczes )
-
10 Nov 2023
Not Applicable
182
Tenofovir alafenamide (TAF)
ycwlkytvmy(ztadhosimp) = fgxewfivzj dlcqisfnrb (xfkxvdpkil )
-
10 Nov 2023
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