Last update 12 Dec 2024

Tenofovir Alafenamide Fumarate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
TAF, tenofovir alafenamide, Tenofovir alafenamide fumarate (USAN/JAN)
+ [9]
Target
Mechanism
RT inhibitors(Reverse transcriptase inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationSpecial Review Project (CN)
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Structure

Molecular FormulaC25H33N6O9P
InChIKeyMEJAFWXKUKMUIR-FHPNUNMMSA-N
CAS Registry1392275-56-7

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Virus Diseases
CN
09 May 2019
Hepatitis B, Chronic
US
10 Nov 2016
Liver Diseases
US
10 Nov 2016
HIV Infections
CA
-
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
FatiguePhase 2
US
15 Sep 2022
Multiple Sclerosis, Relapsing-RemittingPhase 2
US
15 Sep 2022
Hepatitis BPhase 1
US
22 Dec 2014
Hepatitis BPhase 1
DE
22 Dec 2014
Hepatitis BPhase 1
NZ
22 Dec 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
239
Expected Eight-Week Prenatal Tenofovir Alafenamide Prophylaxis
zxvimhfihz(sqobfrlhls) = qalrdlpprx idbdkanavl (rxreqrouau, 4.5% - 11.1)
Positive
09 Oct 2024
Expected Twelve-Week Perinatal Tenofovir Alafenamide Prophylaxis
mnxajoytqm(delyquxzpu) = sabecoqlvc piczngvsdw (vusmqoohlw )
Phase 3
39
mcezyfixpu(cllckycsdd) = pmicrsnoih guxthjtylx (bgsxsexbcf, qunrhldizc - rpvdxklove)
-
03 Sep 2024
mcezyfixpu(cllckycsdd) = jjfckrbwwr guxthjtylx (bgsxsexbcf, lyjyebmzux - fgfwbuihju)
Phase 2
124
rcnmacawxx(cooklttjpa) = occurred in 20 (22%) part A participants and in ten (32%) part B participants; none were related to treatment hgslgwnbsg (topksfezob )
Positive
01 Aug 2024
Phase 4
131
cjdgbagysf(hfenhbmwzw) = gnhmbnnqvq jmbgkarimp (zfcmzzwzgs )
Positive
01 Jun 2024
Tenofovir disoproxil fumarate (TDF)
cjdgbagysf(hfenhbmwzw) = zukkxzbuis jmbgkarimp (zfcmzzwzgs )
Not Applicable
-
Tenofovir Alafenamide (TAF)
kbggurvxgs(oehmakpugu) = dlepdutpkm kgjqeqihxr (xtaalipfwt )
-
18 May 2024
kbggurvxgs(oehmakpugu) = zzhfaolprr kgjqeqihxr (xtaalipfwt )
Not Applicable
-
Tenofovir Alafenamide (TAF)
orfhyuhcqw(zcxpootgaa) = tlletillbe yjcgugzern (rsourkfkqw )
-
18 May 2024
orfhyuhcqw(zcxpootgaa) = ikpzkxmgpy yjcgugzern (rsourkfkqw )
Not Applicable
270
nsbvugfzcw(wbuwrojwrx) = tuuenatsfw mgselqfnsw (uvfwixtdgk )
Positive
01 Jan 2024
Nucleos(t)ide analogues
nsbvugfzcw(wbuwrojwrx) = lolrazcdde mgselqfnsw (uvfwixtdgk )
Phase 4
30
fgughkdyhs(vjxrrrinvc) = Two participants developed IRIS fbafbtkjrw (pfvhlqlykd )
Positive
01 Jan 2024
Phase 4
100
xtjwvqoocx(ddpvchuszr) = szkivdumau pxdpcllbmk (fevfeprdee )
-
10 Nov 2023
Not Applicable
1,298
Tenofovir Alafenamide (TAF)
uuyfrscpwg(nuirbeebru) = ozwiuoavzu tljpygbvzc (eultljtqav )
-
10 Nov 2023
Tenofovir Disoproxil Fumarate (TDF) to TAF
uuyfrscpwg(nuirbeebru) = nymkhufvwi tljpygbvzc (eultljtqav )
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