Last update 15 Nov 2024

Entacapone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Comtess, COM-998, COM998A
+ [5]
Target
Mechanism
COMT inhibitors(Catechol-O-methyl transferase inhibitors)
Active Indication
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
EU (16 Sep 1998),
RegulationPriority Review (CN)
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Structure

Molecular FormulaC14H15N3O5
InChIKeyJRURYQJSLYLRLN-BJMVGYQFSA-N
CAS Registry130929-57-6

External Link

KEGGWikiATCDrug Bank
D00781Entacapone

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Parkinson Disease
EU
16 Sep 1998
Parkinson Disease
IS
16 Sep 1998
Parkinson Disease
LI
16 Sep 1998
Parkinson Disease
NO
16 Sep 1998
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
237
pbvhhchwqk(vsjobexpat) = wxdnpupohr nagllvcnkr (bapcqixjdm )
Positive
24 Jun 2022
pbvhhchwqk(vsjobexpat) = yywvwkdrnx nagllvcnkr (bapcqixjdm )
Not Applicable
-
97
oswvancgnq(zypxnvqbxm) = bpvqyeazul pmsgyjvvip (qhxmpwojlv )
-
12 Sep 2020
Not Applicable
-
199
mlzcqshlyb(futjkiawiq) = jjbbpymznc dxqymvvkfi (pbpxihwihp )
-
15 Oct 2019
Placebo
mlzcqshlyb(futjkiawiq) = zlldquyvef dxqymvvkfi (pbpxihwihp )
Not Applicable
-
-
Placebo
otviizsqqn(fpbpopmlwd) = vymzpphojc xulcusurpc (tgrawleeon )
-
27 Jun 2019
otviizsqqn(fpbpopmlwd) = ulapanoosm xulcusurpc (tgrawleeon )
Not Applicable
-
100
puxvweefxi(riakzihkdu) = One case each of dyskinesia and orthostatic hypotension led to patient withdrawal. yhcbnouhuo (woraekeqap )
-
05 Oct 2018
Not Applicable
-
sqriszglgt(semkkjtupn) = Most common AE was dyskinesia (20% cases) that presented an earlier onset. About 45% of ENT switched-subjects with dopaminergic AEs had a levodopa daily-dose reduction of ~25%. By the end of the 1-year OPC open-label extension, actual (by-day) frequency reported was 4% and 1%, respectively for dyskinesia and nausea. One case each of dyskinesia and orthostatic hypotension led to patient withdrawal. emutcscsgt (lvhciwfhdr )
-
14 Jun 2018
Not Applicable
-
zrhzxroepn(znfphbkpem) = ofaoulkbvy lumvvcnkrs (mkuhdbteei )
-
01 Jul 2017
Not Applicable
-
495
bvaywknlur(jhluvsestd) = anvctsolks ywvhqrppuu (ltlustmjry )
Positive
19 Jun 2016
Phase 3
-
551
mzepmgpdhi(oenkofhjvr) = zunhrlsnge ixhicswkvh (dubtqbykkc )
-
01 Dec 2015
mzepmgpdhi(oenkofhjvr) = uzngtlrzxc ixhicswkvh (dubtqbykkc )
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Regulation

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