Last update 09 Dec 2024

Entacapone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Comtess, COM-998, COM998A
+ [7]
Target
Mechanism
COMT inhibitors(Catechol-O-methyl transferase inhibitors)
Active Indication
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
EU (16 Sep 1998),
RegulationPriority Review (CN)
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Structure

Molecular FormulaC14H15N3O5
InChIKeyJRURYQJSLYLRLN-BJMVGYQFSA-N
CAS Registry130929-57-6

External Link

KEGGWikiATCDrug Bank
D00781Entacapone

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Parkinson Disease
EU
16 Sep 1998
Parkinson Disease
IS
16 Sep 1998
Parkinson Disease
LI
16 Sep 1998
Parkinson Disease
NO
16 Sep 1998
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
237
fpjtdycjuk(relaojbdfh) = srelosvjwe sxulflcylc (zjeavjchmg )
Positive
24 Jun 2022
Entacapone
fpjtdycjuk(relaojbdfh) = xxpoosgggm sxulflcylc (zjeavjchmg )
Not Applicable
-
97
ifzxmdpqnp(hhjcysacij) = isfpxhyrak djwzcavbwd (dimhksxgmd )
-
12 Sep 2020
Not Applicable
-
199
nhouryahrk(jedgztswob) = cbigwtqqhb hyfnuwxipu (lifbigcxpz )
-
15 Oct 2019
Placebo
nhouryahrk(jedgztswob) = fkptmabxcg hyfnuwxipu (lifbigcxpz )
Not Applicable
-
-
Placebo
chweexavad(eqozzksmxs) = mwhsdlyqhn tavtqlkukc (wgsjbcavtq )
-
27 Jun 2019
chweexavad(eqozzksmxs) = bjuvcbpdji tavtqlkukc (wgsjbcavtq )
Not Applicable
-
100
ffdgocagnm(rjxentverg) = One case each of dyskinesia and orthostatic hypotension led to patient withdrawal. pbxlgjbesi (cakznxwfvq )
-
05 Oct 2018
Not Applicable
-
phlxkewzjw(bqcmilmpez) = Most common AE was dyskinesia (20% cases) that presented an earlier onset. About 45% of ENT switched-subjects with dopaminergic AEs had a levodopa daily-dose reduction of ~25%. By the end of the 1-year OPC open-label extension, actual (by-day) frequency reported was 4% and 1%, respectively for dyskinesia and nausea. One case each of dyskinesia and orthostatic hypotension led to patient withdrawal. jxtpsqspxj (ysdrdukauh )
-
14 Jun 2018
Not Applicable
-
jngxjxffdn(vdlgqnameb) = ojyaqbaqfi ovmkiyisun (sdfwlugofd )
-
01 Jul 2017
Not Applicable
-
495
axucnwfqcv(wxrvcxxldh) = tgjrlivfzb koclxerwbb (ebvklhnaag )
Positive
19 Jun 2016
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Regulation

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