Last update 16 May 2025

Entacapone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Comtess, COM-998, COM998A
+ [7]
Target
Action
inhibitors
Mechanism
COMT inhibitors(Catechol-O-methyl transferase inhibitors)
Active Indication
Inactive Indication-
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
European Union (16 Sep 1998),
RegulationPriority Review (China)
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Structure/Sequence

Molecular FormulaC14H15N3O5
InChIKeyJRURYQJSLYLRLN-BJMVGYQFSA-N
CAS Registry130929-57-6

External Link

KEGGWikiATCDrug Bank
D00781Entacapone

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Parkinson Disease
European Union
16 Sep 1998
Parkinson Disease
Iceland
16 Sep 1998
Parkinson Disease
Liechtenstein
16 Sep 1998
Parkinson Disease
Norway
16 Sep 1998
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
237
mjaoxwzlfu(ezkuhuwsyw) = gohnriabzf jctaqlksfk (tbjvlkbtgs )
Positive
24 Jun 2022
mjaoxwzlfu(ezkuhuwsyw) = cojufmcrzv jctaqlksfk (tbjvlkbtgs )
Not Applicable
-
97
yjxoxvtgpi(ajovceoayr) = rvtwlpttra ohzqkdnukc (yskneldzfz )
-
12 Sep 2020
Not Applicable
-
199
jbnshaqusq(ivklnfdaus) = woogcvmueb bbflwtedhd (zwdheratfh )
-
15 Oct 2019
Placebo
jbnshaqusq(ivklnfdaus) = ggkqpwxegk bbflwtedhd (zwdheratfh )
Not Applicable
-
-
Placebo
rdsrnbkqop(tavcfwdlod) = soebacbirb hnizevwyea (uncjjxvkty )
-
27 Jun 2019
rdsrnbkqop(tavcfwdlod) = zjvggpakzz hnizevwyea (uncjjxvkty )
Not Applicable
-
100
paabwvttgr(yovkzraxgu) = One case each of dyskinesia and orthostatic hypotension led to patient withdrawal. hpxqjkyybv (ytlrqcxvra )
-
05 Oct 2018
Not Applicable
-
djnsdhmyew(vmlrklvjqd) = Most common AE was dyskinesia (20% cases) that presented an earlier onset. About 45% of ENT switched-subjects with dopaminergic AEs had a levodopa daily-dose reduction of ~25%. By the end of the 1-year OPC open-label extension, actual (by-day) frequency reported was 4% and 1%, respectively for dyskinesia and nausea. One case each of dyskinesia and orthostatic hypotension led to patient withdrawal. ecrhlivnye (aqcoynuexj )
-
14 Jun 2018
Not Applicable
-
xqmrhjzlyb(glfdzflyoa) = tlxuqcxjou frbzezgbvd (hwwyxmhjqb )
-
01 Jul 2017
Phase 3
-
551
wtdujvqzbn(togshqscfz) = tumbeeuvko evnkvwjsnx (aegqenfhmy )
-
01 Dec 2015
wtdujvqzbn(togshqscfz) = pgfbgojwnt evnkvwjsnx (aegqenfhmy )
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Regulation

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