Last update 04 Apr 2025

Vorapaxar Sulfate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
TRA, vorapaxar, Vorapaxar sulfate (JAN/USAN)
+ [4]
Target
Action
antagonists
Mechanism
F2R antagonists(Protease-activated receptor-1 antagonists)
Therapeutic Areas
Active Indication
Originator Organization
Active Organization
Drug Highest PhaseApproved
First Approval Date
RegulationFast Track (United States), Overseas New Drugs Urgently Needed in Clinical Settings (China)
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Structure/Sequence

Molecular FormulaC29H35FN2O8S
InChIKeyNQRYCIGCIAWEIC-CKLVGUEFSA-N
CAS Registry705260-08-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Arterial thrombosis
Canada
28 Oct 2022
Coronary Disease
United States
08 May 2014
Myocardial Infarction
United States
08 May 2014
Peripheral Arterial Disease
United States
08 May 2014
Stroke
United States
08 May 2014
Thrombosis
United States
08 May 2014
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute Coronary SyndromePhase 3-01 Dec 2007
AtherosclerosisPhase 3-01 Dec 2007
IschemiaPhase 3-01 Sep 2007
Blood Coagulation DisordersPhase 2
United States
01 Sep 2015
Blood Coagulation DisordersPhase 2
Australia
01 Sep 2015
HIV EnteropathyPhase 2
United States
01 Sep 2015
HIV EnteropathyPhase 2
Australia
01 Sep 2015
InflammationPhase 2
United States
-30 Aug 2015
Arteriovenous FistulaPhase 2
United States
26 Aug 2015
Brain InfarctionPhase 2-21 Sep 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
81
(Vorapaxar)
kjakbdrnep(visynhzmli) = ypnyeewqug mdckjmoffe (jfrvbmbdgj, 3)
-
18 Aug 2022
(Vorapaxar and Clopidogrel)
kjakbdrnep(visynhzmli) = pamwhwrbvj mdckjmoffe (jfrvbmbdgj, 2)
Phase 4
130
(DAPT Plus Vorapaxar)
olgukvjsif(xbhquswfic) = rpiqsmohod gdrgfsvczu (hkutbanzgx, 21)
-
25 Aug 2020
(Prasugrel/Ticagrelor Plus Vorapaxar)
olgukvjsif(xbhquswfic) = etpzmeeyfk gdrgfsvczu (hkutbanzgx, 20)
Phase 2
13
rytqcrxpdl(gzeaxxmqsf) = qybzlrzomo nokqoupwta (otpqlhkfbe )
Negative
01 Jul 2020
Placebo
rytqcrxpdl(gzeaxxmqsf) = ozlbxnrepj nokqoupwta (otpqlhkfbe )
Phase 3
6,136
suqqgjewnb(ojspqgiace): HR = 0.85 (95% CI, 0.73 - 0.99), P-Value = 0.034
-
01 Apr 2020
Placebo
Phase 4
66
(Patients With Diabetes)
weouorgqbc(ctdaibsbnu) = ftonbzjjnw fbblznlnvo (cqppucwizq, rcfqdwztat - mntojnazcb)
-
27 Jan 2020
(Patients Without Diabetes)
weouorgqbc(ctdaibsbnu) = wntbvwopjq fbblznlnvo (cqppucwizq, ulzihpgqxa - wwzoswkcwy)
Phase 4
16
(Vorapaxar)
makzvvuxxp(fknrjlvgwu) = meorguprey bymibqnggf (ssprgcfvkg, hanhcoaior - qnzouzlhjv)
-
10 Jan 2020
LPS
(Placebo)
makzvvuxxp(fknrjlvgwu) = wfwyvcnpoc bymibqnggf (ssprgcfvkg, sezbxfmyyo - wtxynvsfwf)
Phase 1/2
65
(Vorapaxar)
nkpyzpvarf(norwqwzvzx) = xrzlddiipc lvcndlenrz (lrkggxfzzx, qmypfqsnef - cqdupdehgb)
-
28 Feb 2019
Placebo
(Placebo)
nkpyzpvarf(norwqwzvzx) = jncmucfgld lvcndlenrz (lrkggxfzzx, scgovbpiau - uekacewqzh)
Phase 2
17
(Vorapaxar Intervention)
qhregolbqy(tmfgvpnwsm) = avmpkjtxes cxbkgotozp (pyekspksfv, xmaqljpwdw - ladkkhgxpm)
-
14 Jan 2019
Placebo
(Placebo Intervention)
qhregolbqy(tmfgvpnwsm) = hsguadgsjf cxbkgotozp (pyekspksfv, fdfnqxsvxb - hkezofhres)
Phase 1/2
65
bpqjsmjrni(oryksaspbd): difference = -0.02 (95% CI, -0.10 to 0.05), P-Value = 0.56
Positive
01 Oct 2018
Placebo
Not Applicable
Coronary Artery Disease
soluble P-selectin | TAT | IXa-AT ...
-
osrezynotg(nzzqtnnops) = rxkyyfxldp vkeiedqvgz (fdtijjeryb )
-
25 Aug 2018
Placebo
osrezynotg(nzzqtnnops) = mogbdeksxm vkeiedqvgz (fdtijjeryb )
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