Last update 24 Jun 2024

Mirzotamab clezutoclax

Overview

Basic Info

Drug Type
Antibody drug conjugate (ADC)
Synonyms
Mirzotamab clezutoclax, ABBV-155, ABBV155
Mechanism
Bcl-xl inhibitors(Apoptosis regulator Bcl-X inhibitors), CD276 inhibitors(CD276 antigen inhibitors)
Therapeutic Areas
Inactive Indication-
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhasePhase 1
First Approval Date-
Regulation-

Structure

Molecular FormulaC11H22N4O4
InChIKeyAGGWFDNPHKLBBV-YUMQZZPRSA-N
CAS Registry159858-33-0
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Malignant Solid NeoplasmPhase 1
US
13 Jul 2018
Advanced Malignant Solid NeoplasmPhase 1
JP
13 Jul 2018
Advanced Malignant Solid NeoplasmPhase 1
AU
13 Jul 2018
Advanced Malignant Solid NeoplasmPhase 1
CA
13 Jul 2018
Advanced Malignant Solid NeoplasmPhase 1
IL
13 Jul 2018
Advanced Malignant Solid NeoplasmPhase 1
NL
13 Jul 2018
Advanced Malignant Solid NeoplasmPhase 1
PR
13 Jul 2018
Advanced Malignant Solid NeoplasmPhase 1
KR
13 Jul 2018
Advanced Malignant Solid NeoplasmPhase 1
ES
13 Jul 2018
Advanced Malignant Solid NeoplasmPhase 1
TW
13 Jul 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
78
Mirzo-C
(SCLC)
jqaqrboghz(wgiviqewkd) = vhghbqxull bklerktzvq (nlqvuyyiip )
Positive
31 May 2023
Mirzo-C + docetaxel
(NSCLC)
jqaqrboghz(wgiviqewkd) = oucoohbfzy bklerktzvq (nlqvuyyiip )
Phase 1
59
aghnrjzzjf(iinonixuiq) = There were no dose limiting toxicities (DLT) reported with monoTx. In comboTx, 2 pts experienced a DLT: Grade 4 neutrophil count decreased and Grade 3 lymphocyte count decreased considered related to paclitaxel. lfyynbbrdg (ixlxkcfcxg )
Positive
20 May 2021
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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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