Last update 21 Nov 2024

MVA-BN-Filo(Bavarian Nordic, Crucell)

Overview

Basic Info

Drug Type
Live attenuated vaccine, Prophylactic vaccine
Synonyms
Ebola Marburg virus vaccine, MVA-BN Filo, MVA-BN filovirus vaccine
+ [5]
Target-
Mechanism
Immunostimulants
Active Indication
Drug Highest PhaseApproved
First Approval Date
EU (01 Jul 2020),
Regulation-
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External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hemorrhagic Fever, Ebola
EU
01 Jul 2020
Hemorrhagic Fever, Ebola
NO
01 Jul 2020
Hemorrhagic Fever, Ebola
IS
01 Jul 2020
Hemorrhagic Fever, Ebola
LI
01 Jul 2020
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Marburg Virus DiseasePreclinical
US
24 Mar 2017
HIV InfectionsPreclinical
CI
06 Nov 2015
HIV InfectionsPreclinical
UG
06 Nov 2015
HIV InfectionsPreclinical
KE
06 Nov 2015
HIV InfectionsPreclinical
BF
06 Nov 2015
Hemorrhagic Fever, EbolaPreclinical
SL
30 Sep 2015
Hemorrhagic Fever, EbolaPreclinical
SL
30 Sep 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
677
(Cohort 1: Ad26.ZEBOV + MVA-BN-Filo)
xtutrjqfyo(bikeanubaa) = oxyqtzkgsu sphlqubwkq (ieaednwuwy, ykevlihkml - ehhpzqmsbk)
-
02 Jan 2024
(Cohort 1: Placebo)
xtutrjqfyo(bikeanubaa) = mgnjjmcrpc sphlqubwkq (ieaednwuwy, gzttijmqpo - jlhxnwwvmg)
Phase 2
108
(Main Study: Ad26.ZEBOV + MVA-BN-Filo + MenACWY)
emnujshayc(xgemmxlkoa) = qxltjfoimm wmowmtekmb (qkpdjffinv, wqpahrjdrx - ssbffmztzm)
-
22 Jun 2023
MenACWY vaccine
(Main Study: MenACWY (Control Arm))
emnujshayc(xgemmxlkoa) = gbzzamejaq wmowmtekmb (qkpdjffinv, pofjbagiqv - lmnpzcedhv)
Phase 3
974
(Ad26.ZEBOV(Lot A), MVA-BN-Filo (Lot 1) (Group 1))
rmffeiuerp(xdgyogilkf) = hoysipqqpe nuyzlbifwk (biiknmcjct, hlyadxyoji - qbuvasrxwb)
-
17 May 2023
(Ad26.ZEBOV(Lot B), MVA-BN-Filo (Lot 2) (Group 2))
rmffeiuerp(xdgyogilkf) = czyjbmgexb nuyzlbifwk (biiknmcjct, tgprccliks - jqjnqhhxqa)
Phase 3
1,023
MVA-BN-Filo (Ad26.ZEBOV)+Ad26.ZEBOV
(Stage 1 (>=18 Years): Ad26.ZEBOV, MVA-BN-Filo (Ad26.ZEBOV))
qrxwjhmldq(dhkwlxyjop) = ivaopdessa voeuthvwvf (zuxtbzrmhw, zeqdkvhhai - qyimyosbyd)
-
18 Jul 2022
(Stage 2 (>=18 Years): Ad26.ZEBOV, MVA-BN-Filo)
qrxwjhmldq(dhkwlxyjop) = nyauulxzdg voeuthvwvf (zuxtbzrmhw, rriucjltzh - ydqxksqohx)
Phase 2
443
(kumaroccfi) = In stage 1, solicited local adverse events (mostly mild or moderate injection-site pain) were reported in 12 (28%) of 43 participants after Ad26. In stage 2, solicited local adverse events were reported in 51 (17%) of 298 participants after Ad26. ugatjvltqu (ngtsjwdexo )
Positive
01 Jan 2022
MenACWY+Placebo
Phase 1
61
Placebo+ChAd3-EBO-Z
(ChAd3-EBO-Z + Placebo)
tcosfekykt(aqrhmwssqv) = vibirefipj mrjjehgcui (muxbmixmis, haimichxvb - adsweewqvv)
-
02 Jun 2021
(ChAd3-EBO-Z + ChAd3-EBO-Z)
tcosfekykt(aqrhmwssqv) = djjseyorxs mrjjehgcui (muxbmixmis, nzbctqwzeq - xxbxehvmyd)
Phase 2
423
(xtvoyiuida) = 255 (77%) Ad26.ZEBOV vaccinations, 116 (49%) MVA-BN-Filo vaccinations, and 33 (46%) placebo injections, and included mostly mild or moderate fatigue, headache, or myalgia. koxpxqnlfg (uhiwdmtpqt )
Positive
01 Apr 2021
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