Drug Type Live attenuated vaccine, Prophylactic vaccine |
Synonyms Ebola Marburg virus vaccine, MVA-BN Filo, MVA-BN filovirus vaccine + [5] |
Target- |
Mechanism Immunostimulants |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date EU (01 Jul 2020), |
Regulation- |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Hemorrhagic Fever, Ebola | EU | 01 Jul 2020 | |
Hemorrhagic Fever, Ebola | NO | 01 Jul 2020 | |
Hemorrhagic Fever, Ebola | IS | 01 Jul 2020 | |
Hemorrhagic Fever, Ebola | LI | 01 Jul 2020 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Marburg Virus Disease | Preclinical | US | 24 Mar 2017 | |
HIV Infections | Preclinical | CI | 06 Nov 2015 | |
HIV Infections | Preclinical | UG | 06 Nov 2015 | |
HIV Infections | Preclinical | KE | 06 Nov 2015 | |
HIV Infections | Preclinical | BF | 06 Nov 2015 | |
Hemorrhagic Fever, Ebola | Preclinical | SL | 30 Sep 2015 | |
Hemorrhagic Fever, Ebola | Preclinical | SL | 30 Sep 2015 |
Phase 3 | 677 | (Cohort 1: Ad26.ZEBOV + MVA-BN-Filo) | xtutrjqfyo(bikeanubaa) = oxyqtzkgsu sphlqubwkq (ieaednwuwy, ykevlihkml - ehhpzqmsbk) View more | - | 02 Jan 2024 | ||
(Cohort 1: Placebo) | xtutrjqfyo(bikeanubaa) = mgnjjmcrpc sphlqubwkq (ieaednwuwy, gzttijmqpo - jlhxnwwvmg) View more | ||||||
Phase 2 | 108 | (Main Study: Ad26.ZEBOV + MVA-BN-Filo + MenACWY) | emnujshayc(xgemmxlkoa) = qxltjfoimm wmowmtekmb (qkpdjffinv, wqpahrjdrx - ssbffmztzm) View more | - | 22 Jun 2023 | ||
MenACWY vaccine (Main Study: MenACWY (Control Arm)) | emnujshayc(xgemmxlkoa) = gbzzamejaq wmowmtekmb (qkpdjffinv, pofjbagiqv - lmnpzcedhv) View more | ||||||
Phase 3 | 974 | (Ad26.ZEBOV(Lot A), MVA-BN-Filo (Lot 1) (Group 1)) | rmffeiuerp(xdgyogilkf) = hoysipqqpe nuyzlbifwk (biiknmcjct, hlyadxyoji - qbuvasrxwb) View more | - | 17 May 2023 | ||
(Ad26.ZEBOV(Lot B), MVA-BN-Filo (Lot 2) (Group 2)) | rmffeiuerp(xdgyogilkf) = czyjbmgexb nuyzlbifwk (biiknmcjct, tgprccliks - jqjnqhhxqa) View more | ||||||
Phase 3 | 1,023 | MVA-BN-Filo (Ad26.ZEBOV)+Ad26.ZEBOV (Stage 1 (>=18 Years): Ad26.ZEBOV, MVA-BN-Filo (Ad26.ZEBOV)) | qrxwjhmldq(dhkwlxyjop) = ivaopdessa voeuthvwvf (zuxtbzrmhw, zeqdkvhhai - qyimyosbyd) View more | - | 18 Jul 2022 | ||
(Stage 2 (>=18 Years): Ad26.ZEBOV, MVA-BN-Filo) | qrxwjhmldq(dhkwlxyjop) = nyauulxzdg voeuthvwvf (zuxtbzrmhw, rriucjltzh - ydqxksqohx) View more | ||||||
Phase 2 | 443 | (kumaroccfi) = In stage 1, solicited local adverse events (mostly mild or moderate injection-site pain) were reported in 12 (28%) of 43 participants after Ad26. In stage 2, solicited local adverse events were reported in 51 (17%) of 298 participants after Ad26. ugatjvltqu (ngtsjwdexo ) View more | Positive | 01 Jan 2022 | |||
MenACWY+Placebo | |||||||
Phase 1 | 61 | Placebo+ChAd3-EBO-Z (ChAd3-EBO-Z + Placebo) | tcosfekykt(aqrhmwssqv) = vibirefipj mrjjehgcui (muxbmixmis, haimichxvb - adsweewqvv) View more | - | 02 Jun 2021 | ||
(ChAd3-EBO-Z + ChAd3-EBO-Z) | tcosfekykt(aqrhmwssqv) = djjseyorxs mrjjehgcui (muxbmixmis, nzbctqwzeq - xxbxehvmyd) View more | ||||||
Phase 2 | 423 | (xtvoyiuida) = 255 (77%) Ad26.ZEBOV vaccinations, 116 (49%) MVA-BN-Filo vaccinations, and 33 (46%) placebo injections, and included mostly mild or moderate fatigue, headache, or myalgia. koxpxqnlfg (uhiwdmtpqt ) | Positive | 01 Apr 2021 |