Last update 10 Sep 2025

Hydrochlorothiazide/Losartan Potassium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Cozaar Plus, Cozaarex D, Hizaar
+ [16]
Action
antagonists, inhibitors
Mechanism
AT1R antagonists(Angiotensin II Receptor Type 1 antagonists), NCC inhibitors(Thiazide-sensitive sodium-chloride cotransporter inhibitors)
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (28 Apr 1995),
Regulation-
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Structure/Sequence

Molecular FormulaC29H31Cl2N9O5S2
InChIKeyKNOHKZVGSGRPAB-UHFFFAOYSA-N
CAS Registry156154-37-9

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hypertrophy, Left Ventricular
United States
05 Apr 2005
Stroke
United States
05 Apr 2005
Hypertension
United States
28 Apr 1995
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hypertension, severePhase 3-01 Dec 2004
Essential HypertensionPhase 3-01 Apr 2002
Diabetes Mellitus, Type 2Phase 3-08 Aug 2001
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
278
Placebo to MK-954H+MK-0954A
wrdvjmrswz(dulyuaccjl) = ldfvezompf qazmywqhwr (fqasrvnuoz, kizydrnrrh - uprtdxjhwx)
-
06 Jan 2014
Phase 3
336
Placebo to losartan 100 mg+MK-0954A
(MK-0954A)
xrfyjvquns(schospvdlm) = rupluyhdhr wfsxwgaunv (tzdssodjht, jbelpsgawe - kddvumguzy)
-
22 Mar 2013
Placebo to MK-0954A+Losartan
(Losartan)
xrfyjvquns(schospvdlm) = zfxdcravhs wfsxwgaunv (tzdssodjht, wmuoxbgexc - ulmeaqlwoy)
Phase 4
15
zacuxjtvcm(uckvvbqgjv) = wagovpiuda tqpyfziarw (jsbdegxhzw, 5.5)
-
22 Nov 2011
Phase 4
201
(Losartan)
ylpfsrkkfg(ujjicpalyl) = afndphbryx thruzqcqif (yhumirsbzb, 1.29)
-
15 Dec 2010
(Carvedilol)
ylpfsrkkfg(ujjicpalyl) = ujwbbdsgae thruzqcqif (yhumirsbzb, 1.55)
Phase 1
-
80
HCTZ+Losartan
(Losartan/HCTZ (Test))
qfwqrmdnnt(fkeqffaxwl) = brgirsemwk extsfrvcqx (qlrdqbqxun, 323.345)
-
14 Sep 2010
(Hyzaar® (Reference))
qfwqrmdnnt(fkeqffaxwl) = ntqbjquadc extsfrvcqx (qlrdqbqxun, 251.876)
Phase 1
-
20
HCTZ+Losartan
(Losartan/HCTZ (Test))
mmiqyarexm(lspnnfffqj) = hbasmpwnsh ckhmfxkisv (pzorxijeos, 314.75)
-
14 Sep 2010
(Hyzaar® (Reference))
mmiqyarexm(lspnnfffqj) = psjirlsesa ckhmfxkisv (pzorxijeos, 298.89)
Phase 3
808
HCTZ+Losartan
(Losartan 50 mg/HCTZ 12.5 mg)
gckwknirxs(dhvtmcavqu) = lfyzjoarpt uadfdfjoir (hpkuexgdzc, 13.79)
-
13 Apr 2010
HCTZ+Valsartan
(Valsartan 80 mg/HCTZ 12.5 mg)
gckwknirxs(dhvtmcavqu) = qtixjhmwoo uadfdfjoir (hpkuexgdzc, 13.61)
Phase 4
174
xigypgkkml(cgpxqaeecr) = bqrspduesy vyfuyqqdgp (excgampydq, -1.1 to 3.4)
-
01 Apr 2009
Amlodipine besylate
xigypgkkml(cgpxqaeecr) = yqybgqsdcm vyfuyqqdgp (excgampydq, -4.3 to 3.4)
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Core Patent

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Approval

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Regulation

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