Small and medium biotechs jump on obesity train
31 Mar 2023
Phase 1Oligonucleotide
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Source: Pharmaceutical Technology
Credit: Getty images/ Coolpicture
This year, competition in the obesity therapeutic landscape has ramped up as biotechs aim to follow the success of blockbuster drugs from Novo Nordisk, Eli Lilly and more. Now, in this hunt for new drugs, small to medium enterprises (SMEs) are also taking their chances in the quickly growing marketplace, with new methods of targeting obesity.
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This topic was at the forefront of a panel on obesity drug development. At the Bio-Europe Spring 2023 conference held on 20-23 March. With more companies entering the obesity market, biotechs are either identifying new GLP-1 agonists to investigate or straying from the currently popular GLP-1 agonism approach in favour of other modalities. At the panel, Italy-based Resalis Therapeutics’s CEO Allesandro Toniolo, described the company’s micro-RNA 22 (miRNA 22) drug as one that will target multiple pathways for targeting obesity. He said, “miRNA 22 acts on three major pathways: lipogenesis and deposition, mitochondria and energy expenditure, and collagen deposition and fibrosis. The level of miRNA22 correlates with these factors, affecting the severity of obesity and Nonalcoholic steatohepatitis (NASH)”. Resalis is developing an antisense oligonucleotide therapy, RES 010, to inhibit miRNA 22.
Additionally, on March 28, Viking Therapeutics announced the launch of Phase I trial to study its oral dual GLP-1/GIPGLP-1/GIP receptor agonist VK2735.
However, several challenges remain in the field of obesity drug development. “[Research] requires huge trials and it’s not clear how a comparison should be made, whether it’s placebo or standard of treatment. The regulatory pathway in diabetes is particularly difficult,” says Toniolo, while describing clinical trials for metabolic disorders. In the panel, Melanie Senior, a biopharma reporter at Nature Biotech also pointed out reimbursement issues for obesity drugs. Toniolo said this is a reason that Resalis’ drug will first enter clinical trials for NASH and rare diseases, before moving on to obesity.
Still, despite some barriers, the success of Novo Nordisk’s Wegovy (semaglutide), Eli Lilly’s Mounjaro (tirzepatide) and more have shown significant success.
Josua Jordi, the CEO of EraCal Therapeutics, another company developing drugs in this space, said obesity could grow as an indication in the coming years. “We see it becoming something like hypertension in the next 10-15 years where patients can select between three to four once daily oral modalities,” said Jordi. Resalis Therapeutics plans to start first in human trials next year and EraCal Therapeutics is still in preclinical stages with developing its small molecule drug, Era-379, for obesity. EraCal already has partnerships with Nestle and Novo Nordisk for research collaboration.
Free Report
How is the Biopharmaceutical industry evolving?
2021 was a year of continued innovation and change in the Biopharmaceutical industry. As the COVID-19 pandemic continues to take its toll on businesses worldwide, it’s time to look for new ways to create value, prepare for the future, and remain competitive in the ever-changing landscape.
GlobalData’s expansive report examines the business environment and trends that shape the Biopharmaceutical industry. We highlight the most impactful emerging technologies, as well as the industry, regulatory, and macroeconomic factors that influence growth prospects.
Access the report to:
Benchmark the impact of major themes on the Biopharmaceutical industry.
Gain a deeper "on the ground" perspective through exclusive opinions and analysis from industry respondents.
Evaluate the effects of COVID-19 on the sector.
Download the full report to understand what to expect and how to align your strategies for success.
By GlobalData
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Source: Pharmaceutical Technology
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UK (+44)
USA (+1)
Algeria (+213)
Andorra (+376)
Angola (+244)
Anguilla (+1264)
Antigua & Barbuda (+1268)
Argentina (+54)
Armenia (+374)
Aruba (+297)
Australia (+61)
Austria (+43)
Azerbaijan (+994)
Bahamas (+1242)
Bahrain (+973)
Bangladesh (+880)
Barbados (+1246)
Belarus (+375)
Belgium (+32)
Belize (+501)
Benin (+229)
Bermuda (+1441)
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Bolivia (+591)
Bosnia Herzegovina (+387)
Botswana (+267)
Brazil (+55)
Brunei (+673)
Bulgaria (+359)
Burkina Faso (+226)
Burundi (+257)
Cambodia (+855)
Cameroon (+237)
Canada (+1)
Cape Verde Islands (+238)
Cayman Islands (+1345)
Central African Republic (+236)
Chile (+56)
China (+86)
Colombia (+57)
Comoros (+269)
Congo (+242)
Cook Islands (+682)
Costa Rica (+506)
Croatia (+385)
Cuba (+53)
Cyprus North (+90392)
Cyprus South (+357)
Czech Republic (+42)
Denmark (+45)
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Dominica (+1809)
Dominican Republic (+1809)
Ecuador (+593)
Egypt (+20)
El Salvador (+503)
Equatorial Guinea (+240)
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Faroe Islands (+298)
Fiji (+679)
Finland (+358)
France (+33)
French Guiana (+594)
French Polynesia (+689)
Gabon (+241)
Gambia (+220)
Georgia (+7880)
Germany (+49)
Ghana (+233)
Gibraltar (+350)
Greece (+30)
Greenland (+299)
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Kiribati (+686)
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Laos (+856)
Latvia (+371)
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Libya (+218)
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Lithuania (+370)
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Macao (+853)
Macedonia (+389)
Madagascar (+261)
Malawi (+265)
Malaysia (+60)
Maldives (+960)
Mali (+223)
Malta (+356)
Marshall Islands (+692)
Martinique (+596)
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Mayotte (+269)
Mexico (+52)
Micronesia (+691)
Moldova (+373)
Monaco (+377)
Mongolia (+976)
Montserrat (+1664)
Morocco (+212)
Mozambique (+258)
Myanmar (+95)
Namibia (+264)
Nauru (+674)
Nepal (+977)
Netherlands (+31)
New Caledonia (+687)
New Zealand (+64)
Nicaragua (+505)
Niger (+227)
Nigeria (+234)
Niue (+683)
Norfolk Islands (+672)
Northern Marianas (+670)
Norway (+47)
Oman (+968)
Palau (+680)
Panama (+507)
Papua New Guinea (+675)
Paraguay (+595)
Peru (+51)
Philippines (+63)
Poland (+48)
Portugal (+351)
Puerto Rico (+1787)
Qatar (+974)
Reunion (+262)
Romania (+40)
Russia (+7)
Rwanda (+250)
San Marino (+378)
Sao Tome & Principe (+239)
Saudi Arabia (+966)
Senegal (+221)
Serbia (+381)
Seychelles (+248)
Sierra Leone (+232)
Singapore (+65)
Slovak Republic (+421)
Slovenia (+386)
Solomon Islands (+677)
Somalia (+252)
South Africa (+27)
Spain (+34)
Sri Lanka (+94)
St. Helena (+290)
St. Kitts (+1869)
St. Lucia (+1758)
Sudan (+249)
Suriname (+597)
Swaziland (+268)
Sweden (+46)
Switzerland (+41)
Syria (+963)
Taiwan (+886)
Tajikstan (+7)
Thailand (+66)
Togo (+228)
Tonga (+676)
Trinidad & Tobago (+1868)
Tunisia (+216)
Turkey (+90)
Turkmenistan (+7)
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Turks & Caicos Islands (+1649)
Tuvalu (+688)
Uganda (+256)
UK (+44) -->
Ukraine (+380)
United Arab Emirates (+971)
Uruguay (+598)
USA (+1) -->
Uzbekistan (+7)
Vanuatu (+678)
Vatican City (+379)
Venezuela (+58)
Vietnam (+84)
Virgin Islands - British (+1284)
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Wallis & Futuna (+681)
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Gambia
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Ghana
Gibraltar
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Greenland
Grenada
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Guam
Guatemala
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Guinea
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Guyana
Haiti
Heard Island and McDonald Islands
Holy See
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Indonesia
Iran
Iraq
Ireland
Isle of Man
Israel
Italy
Jamaica
Japan
Jersey
Jordan
Kazakhstan
Kenya
Kiribati
North Korea
South Korea
Kuwait
Kyrgyzstan
Lao
Latvia
Lebanon
Lesotho
Liberia
Libyan Arab Jamahiriya
Liechtenstein
Lithuania
Luxembourg
Macao
Macedonia, The Former
Yugoslav Republic of
Madagascar
Malawi
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Maldives
Mali
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Marshall Islands
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New Caledonia
New Zealand
Nicaragua
Niger
Nigeria
Niue
Norfolk Island
Northern Mariana Islands
Norway
Oman
Pakistan
Palau
Palestinian Territory
Panama
Papua New Guinea
Paraguay
Peru
Philippines
Pitcairn
Poland
Portugal
Puerto Rico
Qatar
Réunion
Romania
Russian Federation
Rwanda
Saint Helena, Ascension and Tristan da Cunha
Saint Kitts and Nevis
Saint Lucia
Saint Pierre and Miquelon
Saint Vincent and The Grenadines
Samoa
San Marino
Sao Tome and Principe
Saudi Arabia
Senegal
Serbia
Seychelles
Sierra Leone
Singapore
Slovakia
Slovenia
Solomon Islands
Somalia
South Africa
South Georgia and The South
Sandwich Islands
Spain
Sri Lanka
Sudan
Suriname
Svalbard and Jan Mayen
Swaziland
Sweden
Switzerland
Syrian Arab Republic
Taiwan
Tajikistan
Tanzania
Thailand
Timor-Leste
Togo
Tokelau
Tonga
Trinidad and Tobago
Tunisia
Turkey
Turkmenistan
Turks and Caicos Islands
Tuvalu
Uganda
Ukraine
United Arab Emirates
US Minor Outlying Islands
Uruguay
Uzbekistan
Vanuatu
Venezuela
Vietnam
British Virgin Islands
US Virgin Islands
Wallis and Futuna
Western Sahara
Yemen
Zambia
Zimbabwe
Kosovo
-->
-->
-->
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