Diabetic Retinopathy Clinical Trial Pipeline Space Brims With Novel Emerging Therapies with Over 50 Key Companies Working in the Domain | DelveInsight

29 May 2023
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The prevalence of diabetic retinopathy has been rising over the past few years, which prompts the growing demand for treatment options. The increasing prevalence of diabetic retinopathy and the growing research and development activities to develop novel therapies to treat diabetic retinopathy to drive the market. The companies developing the potential therapies in the last stage of development include Roche,
Kodiak Sciences, Novartis, and several others.
LAS VEGAS, May 29, 2023 /PRNewswire/ -- DelveInsight's
'
Diabetic Retinopathy Pipeline Insight – 2023
' report provides comprehensive global coverage of pipeline diabetic retinopathy therapies in various stages of clinical development, major pharmaceutical companies working to advance the pipeline space and future growth potential of the diabetic retinopathy pipeline domain.
Key Takeaways from the Diabetic Retinopathy Pipeline Report
DelveInsight's diabetic retinopathy pipeline report depicts a robust space with
50+ active players working to develop
55+ pipeline therapies for diabetic retinopathy treatment.
Key diabetic retinopathy companies such as
Promising diabetic retinopathy pipeline therapies in various stages of development include
In May 2023, Oculic Holding AG announced positive top-line results from Stage 1 of its
Phase III DIAMOND trial of
OCS-01 eye drops in diabetic macular edema (DME). According to the company, the DIAMOND trial in diabetic macular edema with topical
OCS-01 met its stage 1 objective of validating the loading and maintenance dosing regimen designed to optimize
OCS-01 efficacy potential with robust statistical significance.
In April 2023,
The International Journal of Molecular Sciences published a manuscript,
"Stimulating the Melanocortin System in Uveitis and Diabetes Preserves the Structure and Anti-Inflammatory Activity of the Retina" by Tat Fong Ng and Andrew W. Taylor from Department of Ophthalmology, Boston University Chobanian and Avedisian School of Medicine, in Boston, Massachusetts. The manuscript summarizes data demonstrating the effects of
PL8331 in two mouse models of retinal disease, experimental autoimmune uveoretinitis (EAU) and diabetic retinopathy (DR).
Palatin and the
Massachusetts Lions Eye Research Foundation provided funding for the study.
In February 2023, Ocugen announced that it had submitted an
Investigational New Drug application (IND) with the US Food and Drug Administration (FDA) to initiate a Phase 1 clinical trial of
OCU200, a fusion protein with a distinct mechanism of action (MOA), for the treatment of diabetic macular edema (DME). This regulatory milestone fulfills the Company's commitment to file the IND for
OCU200 within the first quarter of 2023.
In January 2023, Ocuphire Pharma announced topline efficacy and safety results from its
ZETA-1 Phase II trial evaluating oral
APX3330 for the treatment of diabetic retinopathy (DR). Oral
APX3330 demonstrated favorable safety and tolerability allowing for a potential attractive non-invasive option for protection of vision in both eyes in DR patients.
In May 2022, EyePoint Pharmaceuticals announced the
EYP-1901 license to
Betta Pharmaceuticals, to develop and commercialize
EYP-1901 in China, Hong Kong, Macau, and Taiwan. EyePoint retains all rights for
EYP-1901 in the rest of the world and expands its exclusive rights to local delivery of vorolanib for the treatment of all ophthalmic diseases, including diabetic macular edema (DME).
Request a sample and discover the recent advances in diabetic retinopathy drug treatment @
Diabetic Retinopathy Pipeline Report
The diabetic retinopathy pipeline report provides detailed profiles of pipeline assets, a comparative analysis of clinical and non-clinical stage diabetic retinopathy drugs, inactive and dormant assets, a comprehensive assessment of driving and restraining factors, and an assessment of opportunities and risks in the diabetic retinopathy clinical trial landscape.
Diabetic Retinopathy Overview
Diabetic retinopathy is a microvascular condition caused by diabetes mellitus's long-term effects. Diabetic retinopathy can cause vision-threatening retinal damage, eventually leading to blindness. It is found in one-third of patients with diabetes and is linked to an increased risk of life-threatening systemic vascular consequences such as stroke, coronary heart disease, and heart failure. Diabetic retinopathy affects an estimated 40% (8% for vision-threatening retinopathy) of people with type 2 diabetes and 86% (42%) of people with type 1 diabetes in the United States.
The keys to avoiding diabetic retinopathy blindness are early detection and appropriate intervention. Several large studies have found that the onset of diabetic retinopathy does not usually occur within the first 5 years of type 1 diabetes diagnosis. In contrast, the onset of type 2 diabetes is frequently more subtle, and as a result, retinal damage may be evident at the time of diagnosis. As a result, screening for diabetic retinopathy is advised in type 2 diabetics at the time of diagnosis.
Find out more about drugs for diabetic retinopathy @
New Diabetic Retinopathy Drugs
A snapshot of the Diabetic Retinopathy Pipeline Drugs mentioned in the report:
Learn more about the emerging diabetic retinopathy pipeline therapies @
Diabetic Retinopathy Clinical Trials
Diabetic Retinopathy Therapeutics Assessment
The
diabetic retinopathy pipeline report proffers an integral view of diabetic retinopathy emerging novel therapies segmented by stage, product type, molecule type, mechanism of action, and route of administration.
Scope of the Diabetic Retinopathy Pipeline Report
Coverage: Global
Diabetic Retinopathy Therapeutic Assessment By Product Type: Mono, Combination, Mono/Combination
Diabetic Retinopathy Therapeutic Assessment By Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III
Diabetic Retinopathy Therapeutics Assessment
By Route of Administration: Oral, Intravenous, Subcutaneous, Parenteral, Topical
Diabetic Retinopathy Therapeutics Assessment
By Molecule Type: Recombinant fusion proteins, Small molecule, Monoclonal antibody, Peptide, Polymer, Gene therapy
Diabetic Retinopathy Therapeutics Assessment
By Mechanism of Action: Vascular endothelial growth factors inhibitors, Angiogenesis inhibitors, Vascular endothelial growth factor A inhibitors, Gene transference, Integrin alphaVbeta3 antagonists, Integrin alphaVbeta6 inhibitors, Integrin alphavbeta8 inhibitors, Platelet-derived growth factor beta receptor antagonists, Protein tyrosine kinase inhibitors, Proto oncogene protein c-kit inhibitors, Vascular endothelial growth factor receptor 3 antagonists, Vascular endothelial growth factor receptor-1 antagonists, Vascular endothelial growth factor receptor-2 antagonists, Guanylate cyclase stimulants, APEX1 protein inhibitors, DNA apurinic apyrimidinic site lyase inhibitors
Dive deep into rich insights for new drugs for diabetic retinopathy treatment; visit @
Table of Contents
For further information on the diabetic retinopathy pipeline therapeutics, reach out @
Diabetic Retinopathy Drug Treatment
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