NANJING, China, Nov. 22, 2024 /PRNewswire/ -- Nanjing Leads Biolabs Co., Ltd. (hereinafter referred to as "Leads Biolabs") announced that LBL-024, an anti-PD-L1/4-1BB bispecific antibody independently developed by the company with global intellectual property rights for the treatment of neuroendocrine cancer, has obtained Orphan Drug Designation (ODD) from the U.S. Food and Drug Administration (FDA). This marks another significant milestone following the Breakthrough Therapy Designation granted

First patients dosed in OV-AML-1231, a Phase 2 randomized controlled trial of cusatuzumab in newly diagnosed AML AURORA, CO, USA I November 21, 2024 I OncoVerity, a pioneer in applying advanced bioinformatics to drug development, announced today the closing of a Series A extension financing led by existing investors, argenx and RefinedScience. With this funding, OncoVerity aims to advance its mission to address the unmet medical need of cancer patients, leveraging a unique computational approach

FRIDAY, Nov. 22, 2024 -- Recovery from anti-NMDA receptor (anti-NMDAR) encephalitis continues for three years, but deficits persist, according to a study published online Nov. 20 in Neurology . Juliette Brenner, M.D., from the Erasmus University Medical Center in Rotterdam, Netherlands, and colleagues conducted a large-scale cross-sectional and prospective cohort study to examine the temporal trajectory of anti-NMDAR encephalitis in patients aged older than 16 years who were independent prior t

FRIDAY, Nov. 22, 2024 -- For patients with heart failure with preserved ejection fraction, tirzepatide yields a reduced risk for a composite of death from cardiovascular causes or worsening heart failure, according to a study published online Nov. 16 in the New England Journal of Medicine to coincide with the American Heart Association Scientific Sessions 2024, held from Nov. 16 to 18 in Chicago. Milton Packer, M.D., from the Baylor University Medical Center in Dallas, and colleagues conducted

FRIDAY, Nov. 22, 2024 -- An initial strategy of catheter ablation leads to a lower risk for a composite primary end point than antiarrhythmic drug therapy among patients with ischemic cardiomyopathy and ventricular tachycardia, according to a study published online Nov. 16 in the New England Journal of Medicine to coincide with the American Heart Association Scientific Sessions 2024, held from Nov. 16 to 18 in Chicago. John L. Sapp, M.D., from Dalhousie University in Halifax, Nova Scotia, Canad

HAYWARD, Calif., Nov. 21, 202. Avirmax Biopharma, Inc., a leader in the development of innovative gene therapies, today announced that the first patient has been successfully dosed in the Phase I/IIa clinical trial of ABI-110, the company's first gene therapy drug for the treatment of Wet Age-related Macular Degeneration (AMD) including Polypoidal Choroidal Vasculopathy (PCV). "We are thrilled to announce this significant milestone in the clinical investigation of ABI-110" said Shawn Liu, Ph.D.,

Orion Research Foundation grants EUR 1,109,000 for research in 2025 Press release 22 November, 2024 at 9.00 EET Orion Research Foundation sr is distributing EUR 1,109,000 in research grants based on applications for 2025. Orion Research Foundation awards grants of max EUR 50,000 for 19 researchers for postdoctoral research and max EUR 6,000 for 93 young researchers for doctoral dissertation work. Orion Research Foundation sr is annually distributing its return on investment and donations fro

FRIDAY, Nov. 22, 2024 -- Combination treatment with entinostat and nivolumab results in durable responses in a small subset of patients with advanced pancreatic ductal adenocarcinoma (PDA), according to a study published online Nov. 12 in Nature Communications . Marina Baretti, M.D., from the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University in Baltimore, and colleagues combined entinostat and nivolumab in patients with advanced PDA in a phase 2 study. A 14-day lead-in of en

FRIDAY, Nov. 22, 2024 -- Four years of hormone replacement therapy to help women deal with menopausal symptoms causes no harm to the brain, even over the long term, new research shows. "In the present study, approximately 10 years after 48 months of early menopausal therapy... the cognitive performance of women randomized to [hormone replacement therapy] did not differ from those randomized to placebo," concluded a team led by Carey Gleason , of the University of Wisconsin-Madison. Her team pub

FRIDAY, Nov. 22, 2024 -- An estimated 100,429 youth are living with pediatric inflammatory bowel disease (PIBD) in the United States, according to a research letter published online Nov. 20 in Gastroenterology . Michael D. Kappelman, M.D., M.P.H., from the University of North Carolina at Chapel Hill, and colleagues analyzed two commercial insurance claims datasets along with data from five state Medicaid plans to describe the prevalence of PIBD among individuals younger than 20 years. The resea