Delving into the Latest Updates on Anhui University of Chinese Medicine with Synapse

Overview

Tags

Neoplasms

Nervous System Diseases

Cardiovascular Diseases

Small molecule drug

Antibody drug conjugate (ADC)

Herbal medicine

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Neoplasms	5
Nervous System Diseases	5
Infectious Diseases	1
Endocrinology and Metabolic Disease	1

Top 5 Drug Type	Count

Small molecule drug	8
Herbal medicine	1
Antibody drug conjugate (ADC)	1
Chemical drugs	1

Top 5 Target	Count

HIF-1α(Hypoxia-inducible factor 1 alpha)	1
ACHE(Acetylcholinesterase)	1
EGFR x HER2	1
DUSP1 x MFN2 x TMBIM6 x VDAC1	1
ADP(Adenovirus death protein)	1

Acute lung injury (ALI) is a lung disease characterized by pulmonary edema caused by an excessive inflammatory response within the lungs and disruption of the alveolar capillary barrier, with a high morbidity and mortality rate in critically ill patients. Dry powder inhalers (DPI) are an effective way of administering medication to improve efficacy, and inhalation administration not only improves efficacy but also increases the bioavailability of the drug. Synephrine, a natural ingredient derived from the fruit of the citrus plant in the Brassicaceae family, has anti-inflammatory and antioxidant properties. In the present study, we prepared a synephrine dry powder inhaler (SYN-DPI) by anti-solvent precipitation method and evaluated it in vivo and in vitro. The in vitro results show that SYN-DPI has low hygroscopicity and good aerodynamic properties. The in vitro and in vivo efficacy results showed that SYN-DPI not only had low toxicity but also possessed good anti-inflammatory and antioxidant capacity, which could significantly reduce inflammation, oxidative stress, and lung injury. Pharmacokinetic results showed that inhalation administration significantly increased SYN bioavailability. In conclusion, this study provides inhalation administration of synephrine as an inhalable formulation that can be used to improve ALI.

01 Dec 2025·Inflammation Research

Mechanistic and therapeutic insights into the function of N6-methyladenosine in arthritic diseases

Review

Author: Wang, Bing ; Zhou, Xinyue ; Wu, Yajie ; Miao, Chenggui ; Song, Yingqiu ; Cai, Yikang

OBJECTIVEArthritis is a class of diseases, characterized by joint and surrounding inflammation, accompanied by joint swelling, pain, dysfunction. According to different factors, arthritis can be divided into osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and so on. N6-methyladenosine (m6A) is the most common internal modification of eukaryotic mRNA and is involved in splicing, stabilization, output and degradation of RNA metabolism. This review systematically summarized current insights into the mechanism of m6A in arthritis.METHODSThe studies related to the involvement of m6A in the pathogenesis of arthritis reported in PubMed, Google scholar, and other open source literatures were investigated to evaluate the important roles of m6A in arhtritis, and the clinical relevances.RESULTS AND CONCLUSIONSM6A methylation regulators play the roles of writers, erasers, and readers, are crucial for regulating gene expression, and play important roles in many biological processes such as virus replication and cell differentiation. In addition, more and more studies have shown that m6A is closely related to the development of arthritis. As a new therapeutic target for arthritis, m6A has a wide influence on the pathological mechanism of arthritis. However, further research is needed to determine how m6A affects arthritis pathology and its use in target therapy and diagnosis.

01 Dec 2025·Molecular Biology Reports

Synergistic inhibitory effect of atmospheric pressure plasma and berberine on non‑small cell lung cancer cells via inducing apoptosis

Article

Author: Ming, Huiyun ; Song, Wencheng ; Zhou, Han ; Dai, Haiming ; Lu, Tingting

BACKGROUNDNon-small cell lung cancer (NSCLC) is a type of lung cancer, the incidence and mortality rate have been high, and the use of monotherapy is easy to make patients develop tolerance. Atmospheric pressure plasma (APP) is an emerging technology for killing cancer cells in recent years, and combination of berberine (BBR) mechanism has not been fully elucidated for NSCLC. The article's primary goal is to investigate the effect of combination on NSCLC and its associated characterization.METHODS AND RESULTSAntiproliferative effects were detected by cell viability assay and colony formation, and flow cytometry analysis of apoptosis and cycling showed that the combination synergistically induced apoptosis. Then, extracellular reactive oxygen species (ROS)levels and DCFH-DA-based kits examined intracellular ROS levels, and their effects on mitochondrial membrane potential were measured. Study reveals that co-induced apoptosis is associated with ROS accumulation. Subsequently, Western blotting (WB) detected the expression of epidermal growth factor receptor (EGFR), and the important signaling pathway proteins Ras/ERK and AKT/mTOR. Results showed that it could downregulation of EGFR protein expression and inhibit of activation of ERK/AKT signaling pathways. Simultaneous wound healing assay and epithelial-to-mesenchymal transition (EMT) marker detection were performed for the assessment of migration and EMT ability of NSCLC cells. Combination therapy inhibited migration and EMT of NSCLC cells.CONCLUSIONThe results of this study show that the combination can synergistically induce apoptosis of NSCLC by regulating ROS production. EGFR downregulation and AKT/ERK signaling pathway inhibition are linked to the synergistic effect.

100 Deals associated with Anhui University of Chinese Medicine

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100 Translational Medicine associated with Anhui University of Chinese Medicine

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Pipeline

Pipeline Snapshot as of 01 Jun 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

4

7

Preclinical

Other

1

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Ganoderic acid D(Anhui University of Chinese Medicine) ( HIF-1α )	Breast Cancer More	Preclinical
Ligustilide	Ischemic stroke More	Preclinical
Sodium Houttuyfonate	Colitis More	Preclinical
B2C4-MMAE ( EGFR x HER2 )	Neoplasms More	Preclinical
S-58 ( GluN1 x GluN2B )	Ischemic stroke More	Preclinical