Delving into the Latest Updates on OOO NPF Materia Medica Holding with Synapse

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Nervous System Diseases

Cardiovascular Diseases

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Small molecule drug

Monoclonal antibody

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Disease Domain	Count

Nervous System Diseases	1

Top 5 Drug Type	Count

Small molecule drug	1
Monoclonal antibody	1

Recently, there has been a radical change in understanding of the nature of drugs based on highly diluted solutions. It has been established that their activity does not depend on the content of the original substance in dilutions, but is a consequence of the technological processing (TP) of dilutions with vibration, which accompanies each dilution during the preparation of solutions and, among others, leads to the formation of nanoparticles with certain properties. Repeated vibration treatment leads to the appearance of modifying activity that is absent in the original substance, and these effects of TP solutions can be exerted without direct contact with their targets, which clearly indicates the physical nature of the TP solution’s activity. In the framework of this article, a statistically significant effect of TP antibodies to the insulin receptor on glucose consumption by CHO cells both with and without contact exposure, as compared with control ( P < 0.05) was shown in the vast majority of the experiments. The obtained results shed light on a possible source of activity of drugs based on TP antibodies, which should be associated with the applied vibration effect and can manifest itself both with contact exposure and without it.

01 Feb 2024·Physics of Wave Phenomena

The Effect of Aqueous Solutions Processed Using Gradual Technology on the Emission of a Carbohydrate (Lactose) in the RF Range

Author: Chernikov, D. Yu. ; Novikov, V. V. ; Tarasov, S. A. ; Yablokova, E. V. ; Rodionova, N. N. ; Fedorova, M. M. ; Minakov, A. V. ; Boriskin, V. S. ; Petrova, A. O. ; Stepanov, G. O.

Treatment of antibodies using gradual technol. implies a series of successive dilutions, accompanied by mech. impacts, with subsequent saturation of lactose with the obtained solutionIn comparison with intact lactose, the resulting products have increased emission in the RF frequency range from 50 MHz to 3.5 GHz.

01 Jan 2024·Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

A novel technique for studying the effects of technologically processed antibodies by evaluating the rate of oxidation of ascorbic acid during the reduction of the green–blue ABTS + radical

Article

Author: Don, Elena ; Samsonova, Liudmila ; Alinkina, Ekaterina ; Tarasov, Sergey ; Stepanov, German ; Gizitdinova, Olesia ; Petrova, Anastasia

Since the pharmaceutical market is developing, there is a need for novel techniques for determining the physical-chemical properties of drug solutions. Drugs based on technologically processed antibodies (TPA) are an example of compounds that require a methodology for studying their effects. It has been shown that the process of external impacts during the manufacture of TPA-based drugs can induce breaking of intermolecular and intramolecular bonds in the solvent molecules, providing the emergence of new bonds with the molecules of the substance used for the manufacture of an active pharmaceutical ingredient. This article focuses on the technique applied for assessing the mentioned effect of TPA and consists in spectrophotometric observation of the oxidation process of ascorbic acid (AA) in the solution. The amount of oxidized AA was detected using ABTS·⁺(2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical-cation, which, when interacting with AA, is reduced and changes the color from green-blue to colorless. This technique showed the reproducibility of statistically significant differences in the amount of oxidized AA in the presence of TPA compared to controls and can be used to detect the changes in the properties of solutions exposed to the effect of the TPA samples.

100 Deals associated with OOO NPF Materia Medica Holding

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100 Translational Medicine associated with OOO NPF Materia Medica Holding

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Pipeline

Pipeline Snapshot as of 25 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Phase 3 Clinical

1

Approved

Other

5

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

S-100 protein antibody(Materia Medica Holding)	Anxiety Disorders More	Approved
MMH-MAP	Ischemic stroke More	Phase 3
MMH-407	Influenza, Human More	Suspended
Afalaza ( KLK3 )	Prostatic Hyperplasia More	Pending
Angiotensin-II receptor antibody(Materia Medica Holding Research And Production Company) ( AT1R )	Heart Failure More	Pending