Delving into the Latest Updates on Tianjin Hankang Pharmaceutical Biotechnology Co. Ltd. with Synapse

Overview

Tags

Urogenital Diseases

Other Diseases

Endocrinology and Metabolic Disease

Small molecule drug

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Nervous System Diseases	1
Immune System Diseases	1
Infectious Diseases	1
Endocrinology and Metabolic Disease	1

Top 5 Drug Type	Count

Small molecule drug	3

Top 5 Target	Count

COX-1 x COX-2	1
M1 receptor x M3 receptor	1
PPARα(Peroxisome proliferator-activated receptor α)	1

主要目的：本研究以天津汉瑞药业有限公司持证的非奈利酮片（10mg）为受试制剂，Bayer AG持证的非奈利酮片（商品名：可申达，规格：10mg）为参比制剂，进行空腹/餐后状态下人体生物等效性试验，评价受试制剂和参比制剂在健康受试者体内的生物等效性。次要目的：观察受试制剂和参比制剂在健康受试者中的安全性。

[Translation]

Main purpose: This study used the phenarenic acid tablets (10 mg) certified by Tianjin Hanrui Pharmaceutical Co., Ltd. as the test preparation and the phenarenic acid tablets (trade name: Keshenda, specification: 10 mg) certified by Bayer AG as the reference preparation to conduct a human bioequivalence test under fasting/postprandial conditions to evaluate the bioequivalence of the test preparation and the reference preparation in healthy subjects. Secondary purpose: To observe the safety of the test preparation and the reference preparation in healthy subjects.

Start Date13 Dec 2024

Sponsor / Collaborator

Tianjin Hanrui Pharmaceutical Co., Ltd.

CTR20200801

/ CompletedPhase 1

对乙酰氨基酚注射液在中国健康受试者的开放、单次给药、多次给药的药代动力学试验

[Translation] An open-label, single-dose, and multiple-dose pharmacokinetic study of acetaminophen injection in healthy Chinese subjects

主要目的：评估对乙酰氨基酚注射液在健康中国人体内以325mg和1000mg的给药剂量进行单次给药后的药代动力学特征，以及以500mg给药剂量进行多次给药后的药代动力学特征。次要目的：考察对乙酰氨基酚注射液的安全性。

[Translation]

Primary objective: To evaluate the pharmacokinetic characteristics of acetaminophen injection after single administration of 325 mg and 1000 mg, and after multiple administration of 500 mg in healthy Chinese subjects. Secondary objective: To investigate the safety of acetaminophen injection.

Start Date03 Apr 2020

Sponsor / Collaborator

Tianjin Hankang Pharmaceutical Biotechnology Co. Ltd.

CTR20192617

/ CompletedNot Applicable

枸橼酸托法替布片在健康受试者中随机、开放、自身交叉空腹和餐后状态下的人体生物等效性试验。

[Translation] A randomized, open-label, self-crossover human bioequivalence study of tofacitinib citrate tablets in healthy subjects under fasting and fed conditions.

以杭州朱养心药业有限公司生产的5mg枸橼酸托法替布片为受试制剂，以Pfizer Manufacturing Deutschland GmbH生产的5mg枸橼酸托法替布片（商品名：尚杰®/Xeljanz®）为参比制剂，按生物等效性试验的相关规定，比较单次空腹/餐后口服枸橼酸托法替布片在中国健康受试者体内的药代动力学行为，进行生物等效性评价，为该药注册申报及临床应用提供依据。

[Translation]

Using 5 mg tofacitinib citrate tablets produced by Hangzhou Zhuyangxin Pharmaceutical Co., Ltd. as the test preparation and 5 mg tofacitinib citrate tablets (trade name: Shangjie®/Xeljanz®) produced by Pfizer Manufacturing Deutschland GmbH as the reference preparation, the pharmacokinetic behaviors of a single fasting/postprandial oral tofacitinib citrate tablets in healthy Chinese subjects were compared according to the relevant provisions of the bioequivalence test, and a bioequivalence evaluation was conducted to provide a basis for the registration application and clinical application of the drug.

Start Date18 Dec 2019

Sponsor / Collaborator

Tianjin Hankang Pharmaceutical Biotechnology Co. Ltd.

100 Clinical Results associated with Tianjin Hankang Pharmaceutical Biotechnology Co. Ltd.

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0 Patents (Medical) associated with Tianjin Hankang Pharmaceutical Biotechnology Co. Ltd.

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2

Literatures (Medical) associated with Tianjin Hankang Pharmaceutical Biotechnology Co. Ltd.

17 Jul 2025·JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Bioactivity-guided isolation of benzocoumarin and quinonoid compounds from Rubia schumanniana and their anti-inflammatory activity in vitro.

Article

Author: Zhang, Guan-Ying ; Zhang, Tian-Jian ; Guo, Dan-Dan ; Wang, Miao

The bioactivity-guided isolation was performed to explore bioactive components from 75% ethanol extract of Rubia schumanniana. The structures of ten compounds, including one new benzocoumarin type compound (1) and nine known quinonoids (2-10), were determined by means of analysis of comprehensive spectroscopic data. Anti-inflammatory activity evaluation revealed that compounds 1-10 could inhibit overproduction of NO induced by LPS, and compounds 2-4 and 6-7 exhibited the inhibitory ration more than 50% at 30 μM, especially compound 3 exhibited the strongest inhibitive efficiency with 80.6% inhibition rate. Our work revealed the potential of R. schumanniana as prospective natural source of anti-inflammatory compounds.

CRYSTENGCOMM

A 5-fluorouracil–kaempferol drug–drug cocrystal: a ternary phase diagram, characterization and property evaluation

Author: Liu, Xiao-Xu ; Chen, Jia-Mei ; Long, Xiang-Tian ; Dai, Xia-Lin ; Lv, Wen-Ting

A drug–drug cocrystal of 5-fluorouracil and kaempferol was comprehensively investigated and exhibits optimized solubility behavior in comparison with individual APIs.

100 Deals associated with Tianjin Hankang Pharmaceutical Biotechnology Co. Ltd.

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100 Translational Medicine associated with Tianjin Hankang Pharmaceutical Biotechnology Co. Ltd.

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Pipeline

Pipeline Snapshot as of 25 Aug 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Phase 1

1

Phase 2

Phase 3

1

Other

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Ibuprofen ( COX-1 x COX-2 )	Fever More	Phase 3
Clinofibrate ( PPARα )	Primary Hyperlipidemia More	Phase 2
Imidafenacin ( M1 receptor x M3 receptor )	Pollakisuria More	Phase 1
Acetaminophen ( COXs )	Mild pain More	Pending