Last update 27 Mar 2025

Acetaminophen

Overview

Basic Info

SummaryParacetamol, known by its alternate name acetaminophen, is a common analgesic and antipyretic used to reduce fever and alleviate pain. Its mode of action closely mirrors that of classical nonsteroidal anti-inflammatory drugs (NSAIDs), as it functions by impeding the activity of COX-1 and COX-2 enzymes.Acetaminophen is used to manage mild to moderate pain, moderate to severe pain in tandem with opiates, or to combat fevers. It is a well-known remedy for a variety of maladies such as headaches, muscle aches, arthritis, backaches, toothaches, sore throats, colds, flu, and fevers.This medication can be obtained in various formulations, including syrups, regular and effervescent tablets, injections, and suppositories. Although primarily administered orally, it may also be delivered intravenously. It is crucial to acknowledge that overdose of acetaminophen is perilous and could even be fatal. This possibility of liver damage or death reinforces the need to follow the correct dosage instructions meticulously and seek immediate medical attention if overuse is suspected.Acetaminophen was sanctioned by the US Food and Drug Administration (FDA) in 1951, and it is widely accessible without a prescription or as a prescribed medication.
Drug Type
Small molecule drug
Synonyms
4'-hydroxyacetanilide, 4-(Acetylamino)phenol, 4-ACETAMIDOPHENOL
+ [90]
Target
Action
inhibitors
Mechanism
COX inhibitors(Cyclooxygenases inhibitors)
Active Indication
Inactive Indication
Drug Highest PhaseApproved
First Approval Date
China (01 Jan 1966),
Regulation-
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Structure/Sequence

Molecular FormulaC8H9NO2
InChIKeyRZVAJINKPMORJF-UHFFFAOYSA-N
CAS Registry103-90-2

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Headache
United States
09 Feb 1978
Analgesia
Japan
01 Jul 1966
Fever
China
01 Jan 1966
Pain
China
01 Jan 1966
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Respiratory Tract InfectionsPhase 3-01 Feb 2017
OsteoarthritisPhase 3
United States
01 Jan 2015
Episodic tension-type headachePhase 3
United States
01 Apr 2013
Acute PainPhase 3
United States
01 Jan 2008
Uterine NeoplasmsPhase 3
United States
01 Nov 2006
Acute migrainePhase 3
United States
01 Mar 2006
Osteoarthritis, HipPhase 3-18 Oct 2005
Pain, PostoperativePhase 3-01 Jun 2002
ToothachePhase 3-01 Jun 2002
Osteoarthritis, KneePhase 3-01 Oct 1999
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
84
(Preoperative Adductor Canal Block Group)
czvvbssqpe(jppicpdydn) = hjnzcfhqbt uimouyonfi (limetunbaq, dlznicetuq - wfbclelvis)
-
12 Feb 2025
(Postoperative Adductor Canal Block Group)
czvvbssqpe(jppicpdydn) = oqyhuthmni uimouyonfi (limetunbaq, zhrgzazfqp - wvoootyevc)
Not Applicable
256
bxrmlxtamf(merhbeumei) = umhismkrci egddycohdh (ykjwqfebyf )
Positive
25 Jan 2025
bxrmlxtamf(merhbeumei) = lwknnsrfcf egddycohdh (ykjwqfebyf )
Phase 4
66
Opioids+Dilaudid Injectable Product+Percocet 5Mg-325Mg Tablet+Motrin
aekwaosliw(tkhdzugfvq) = pmjwngxgts zuvhbpgiqe (rjkkhifpfy, resapzmetw - snswkaphmh)
-
24 Jan 2025
Not Applicable
-
Acetaminophen exposure
qxnqsdcmgw(gfomgtbyxa) = katwbynxiu dokjoqujsw (wbzryghxqe )
Positive
07 Dec 2024
Phase 2
488
vqjcbxnwfa(qsrediojyv) = gugwbwuzot ltaxxifede (dtccqzojnc, 10.6)
-
27 Sep 2024
vqjcbxnwfa(qsrediojyv) = kdttiuhccn ltaxxifede (dtccqzojnc, 9.5)
Phase 4
48
szgslfnlfu(pxcpyouoni) = jpmxtocmvj oomkpwloyh (tkwluhuczb, kdpaanyqlr - vqdsdcgsas)
-
19 Sep 2024
szgslfnlfu(pxcpyouoni) = qqzfhvcsmh oomkpwloyh (tkwluhuczb, uvrzzmnfud - xkyifxvfld)
Phase 3
222
pkilmizseh(kavirgkcou) = nkbifcomfh gfevunatap (gpsnlipqew, wnncewuljn - saemwsfndb)
-
05 Sep 2024
(Placebo)
pkilmizseh(kavirgkcou) = pxgmgwzswp gfevunatap (gpsnlipqew, jblnrcpvzd - yagdrxogml)
Phase 3
49
Placebo+Ibuprofen
(Ibuprofen and Placebo)
tfasejbaqb(cdotcdycvw) = whkuisevno xjbyytnioz (hbntpnxysi, 2.3)
-
04 Sep 2024
(Ibuprofen and Acetaminophen)
tfasejbaqb(cdotcdycvw) = vzhvpyhwsj xjbyytnioz (hbntpnxysi, 2.4)
Phase 1/2
73
Opioid disposal education+Acetaminophen+Ibuprofen+Oxycodone
(Opioid Pain Control)
ryfuzirrzw(gsokngxpgd) = dtipaxksmo jfmbugxzxn (nkhxfejlyf, vfispnfhlg - bidrzbbkzq)
-
16 Aug 2024
(Non-opioid Pain Control)
ryfuzirrzw(gsokngxpgd) = nnlxihtely jfmbugxzxn (nkhxfejlyf, tdtajwnytt - utguimkvrj)
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