China Resources Zizhu Pharmaceutical Co., Ltd.

Main purpose: Using epalrestat tablets provided by China Resources Zizhu Pharmaceutical Co., Ltd. as the test preparation, according to the relevant provisions of the bioequivalence test, the absorption rate and degree of epalrestat tablets (trade name: KINEDAK®, reference preparation) produced by Ono Pharmaceutical Co., Ltd. were compared in healthy humans to investigate the bioequivalence of the two preparations. Secondary purpose: To observe the safety of the test preparation epalrestat tablets and the reference preparation epalrestat tablets (KINEDAK®) in healthy subjects.

Primary objective: To study the pharmacokinetic characteristics of the test preparation levonorgestrel tablets (1.5 mg) and the reference preparation levonorgestrel tablets (Bao Shiting, 1.5 mg) in healthy subjects after a single oral administration in the fasting and fed state, and to evaluate the bioequivalence of the two preparations in the fasting and fed state. Secondary objective: To study the safety of the test preparation levonorgestrel tablets (1.5 mg) and the reference preparation (Bao Shiting, 1.5 mg) in healthy subjects.

Primary objective: To evaluate the bioequivalence of the test and reference preparations under fasting and postprandial conditions, using desogestrel ethinyl estradiol tablets (containing 0.15 mg desogestrel and 30 μg ethinyl estradiol per tablet) produced by China Resources Zizhu as the test preparation and desogestrel ethinyl estradiol tablets (trade name: Marvelon®/Marvelon®) produced by the original manufacturer N.V. Organon as the reference preparation. Secondary objective: To observe the safety of the test and reference preparations in healthy Chinese female subjects.